This is an introductory Podcast about Cures Without Side Effects which aims to provide information on how to maintain health with natural treatments without side effects.

It includes various essential and effective methods of healing without side effects according to my knowledge and experience.

More detailed information about health topics you can refer to my books: "Cure Without Side effects" and "Low Dose Medicine" by following these links:

You can also follow my other podcast channel about the Laws of Reality here:

https://open.spotify.com/show/3c13EwktUt3H0VBwNWLCOJ

https://podcasters.spotify.com/pod/show/noageontology

DISCLAIMER: Nothing contained in this Podcast is intended nor can be taken to diagnose, treat, or cure of any disease. It is for informational purposes only.

BDNF was the second neurotrophic factor to be discovered after the Nerve Growth Factor (NGF).

In the brain, BDNF is expressed predominantly in the hippocampus, cortex, and synapses of the basal forebrain areas where it is vital to learning, memory, and higher thinking. BDNF is also expressed in muscles.

BDNF selectively supports the survival of primary sensory neurons, retinal ganglia and the survival and differentiation of certain cholinergic and dopaminergic neurons. It also modulates neural plasticity and predisposition to behaviors.

BDNF can recover re-innervation in the mature cerebellum thus it is applicable in trauma of the central nervous system (CNS). Both BDNF and NGF express neuroprotective effects on myelin, thus they are indicated in multiple sclerosis (MS).

Exposure to stress and the stress hormone corticosterone has been shown to decrease the expression of BDNF which can lead to depression.

On the other hand, the expression of BDNF is increased by voluntary exercise, caloric restriction, intellectual stimulation, curcumin, the neurotransmitter glutamate and various antidepressants drugs.

Various studies have shown possible links between BDNF dysregulation and conditions such as bipolar disorder, schizophrenia, obsessive-compulsive disorder, autism, Huntington's disease, Rett syndrome and dementia, as well as anorexia nervosa and bulimia nervosa.

Post mortem analysis has shown lowered levels of BDNF in the brain tissues of people with Alzheimer's disease and a connection between depression and dementia has been suggested to be mediated by this neurotrophin.

BDNF is also a critical regulator of drug dependency since it causes cravings in opiate-dependent people; on the other hand BDNF has a role in maintaining long-term abstinence from alcohol in people with alcohol dependency.

This episode is also available as a blog post: https://cureswithoutsideffects.wordpress.com/2022/03/28/cytokines-series-brain-derived-neurotrophic-factor-bdnf/

NGF was the first neurotrophic factor to be discovered by Professors Rita Levi-Montalcini and Stanley Cohen in the 1950s; however, its discovery, along with the discovery of other neurotrophins, was not widely recognized until 1986.

NGF is synthesized in the hypothalamus, pituitary, thyroid gland, testis, and it is also produced by vascular smooth muscle cells and fibroblasts.

The expression of NGF in specific neurons of the central nervous system (cortex, hippocampus) can be influenced positively by glutamate and negatively by GABA stimulating neuronal activity.

NGF stimulates the growth and differentiation of B-cells and the growth of T-cells and also promotes the proliferation of mast cells.

Vitamin D3 is potent inducer of NGF synthesis (a possible reason for vitamin D antidepressant action), while glucocorticoids are potent NGF inhibitors.

Studies have shown that NGF seems to prevent or reduce neuronal degeneration in neurodegenerative diseases. It has also been shown to promote peripheral nerve regeneration and has neuroprotective effects on myelin, thus it is indicated in multiple sclerosis (MS).

NGF seems to protect cholinergic neurons in Alzheimer's disease which is characterized by a selective degeneration of these cells.

More detailed information about health topics you can refer to my books: "Cure Without Side effects" and "Low Dose Medicine" by following these links:

►►►https://amzn.to/3Bbx8fd

►►►https://amzn.to/36iaqDU

You can also follow my other podcast channel about the Laws of Reality here:

https://open.spotify.com/show/3c13EwktUt3H0VBwNWLCOJ

https://podcasters.spotify.com/pod/show/noageontology

DISCLAIMER: Nothing contained in this Podcast is intended nor can be taken to diagnose, treat, or cure of any disease. It is for informational purposes only.

This is the fourteenth of a series of short videos on Low Dose Medicine and in particular Cytokines. This video introduces the cytokine  Tumor Necrosis Factor  α , an important inflammatory cytokine. TNF-alpha has a wide spectrum of biological activities, generally together with IL-1 and IL-6, such as prostaglandin synthesis by hypothalamic cells, HPA (hypothalamic-pituitary-adrenal) axis stimulation by stimulating the release of corticotropin releasing hormone (CRH), appetite suppression, fever induction, hepatocytes stimulation for the production of acute phase proteins, hypoglycemia, insulin resistance and stimulation of phagocytosis on macrophages.  High concentrations of TNF induce shock-like symptoms whereas the prolonged exposure to low concentrations of TNF can result in cachexia.  

More detailed information about health topics you can refer to my books: "Cure Without Side effects" and "Low Dose Medicine" by following these links:

►►►https://amzn.to/3Bbx8fd

►►►https://amzn.to/36iaqDU

You can also follow my other podcast channel about the Laws of Reality here:

https://open.spotify.com/show/3c13EwktUt3H0VBwNWLCOJ

https://podcasters.spotify.com/pod/show/noageontology

DISCLAIMER: Nothing contained in this Podcast is intended nor can be taken to diagnose, treat, or cure of any disease. It is for informational purposes only.

This is the thirteenth of a series of short videos on Low dose Medicine and in particular Cytokines. This video introduces the cytokine  IGF 1 , the ‘anti age’ growth factor. Insulin-like growth factor 1 (IGF-1), is a protein similar in molecular structure to insulin mainly produced by the liver.  Its production is stimulated by the growth hormone (GH) and can be retarded by under nutrition or malnutrition, growth hormone insensitivity, lack of growth hormone receptors and it is also reduced with age. In children, it stimulates bone growth and development of organs such as the heart, liver, and kidneys. In humans, the growth hormone (GH) made in the anterior pituitary gland stimulates the liver to produce insulin-like growth factor 1 (IGF-1) which then stimulates and has a growth-promoting effect on almost every cell in the body, especially kidney, muscles, cartilage, liver, nerves, skin, hematopoietic cells, and lungs.  More information about this and other health topics can be found in my books "Low Dose Medicine" and "Cure Without Side effects" by following these links: ►►►https://amzn.to/3Bbx8fd  ►►►https://amzn.to/36iaqDU 

To check the Low dose Medicine health kit follow this link:  ►►►https://kit.co/cureswithoutsideffect/low-dose-medicine 

DISCLAIMER: Nothing contained in this video is intended nor can be taken  to diagnose, treat, or cure any disease. It is for informational purposes only.

This episode is also available as a blog post: https://cureswithoutsideffects.wordpress.com/2022/01/11/cytokines-series-insulin-like-growth-factor-1-igf-1/

This is the  eleventh of a series of short videos on Low dose Medicine and in particular Cytokines. This video introduces the cytokine Granulocyte colony-stimulating factor (G-CSF or GCSF). Granulocyte colony-stimulating factor is a glycoprotein which stimulates the the proliferation and differentiation of hematopoietic progenitor cells from the bone marrow into granulocytes (white blood cells) and neutrophils.  G-CSF is produced by monocytes, macrophages, and neutrophils after cell activation and it is also produced by stromal cells, fibroblasts, and endothelial cells.  G-CSF triggers the reactivity and raises the sensitivity of the immune system, and it enhances the antibody-dependent cell mediated cytotoxicity of granulocytes against tumor cells.   

More information about this and other health topics can be found in my books "Low Dose Medicine" and "Cure Without Side effects" by following these links: ►►►https://amzn.to/3Bbx8fd  ►►►https://amzn.to/36iaqDU To check the Low dose Medicine health kit follow this link:  ►►►https://kit.co/cureswithoutsideffect/low-dose-medicine 

DISCLAIMER: Nothing contained in this video is intended nor can be taken  to diagnose, treat, or cure any disease. It is for informational purposes only.

This is the  tenth of a series of short videos on Low dose Medicine and in particular Cytokines. This video introduces the cytokine Interleukin 12. IL 12 is also known as a T cell-stimulating factor because it can stimulate the growth and function of T cells and especially the differentiation of naive T cells into Th1 cells (cell mediated immunity).  IL-12 enhances the cytotoxic activity of NK cells and CD8+ cytotoxic T lymphocytes and also induces the synthesis of IFN-gamma, IL2, and TNF-alpha (TNF-α).  IL-12 inhibits the synthesis of IgE induced by IL-4 and can therefore be useful in allergic diseases.   IL 12 has anti-angiogenic (it can block the formation of new blood vessels), anti-tumoral and anti-metastatic activity, and because of this, it has been proposed by immunologists as a possible anti-cancer drug (although in pharmacological doses it can cause many side-effects).  IL 12 is the most important cytokine with IL 2 and interferon gamma (IFN-gamma) in neoplastic pathologies (cancer support therapy) in general and especially melanomas and kidneys carcinoma.  

More information about this and other health topics can be found in my books "Low Dose Medicine" and "Cure Without Side effects" by following these links: ►►►https://amzn.to/3Bbx8fd  ►►►https://amzn.to/36iaqDU To check the Low dose Medicine health kit follow this link:  ►►►https://kit.co/cureswithoutsideffect/low-dose-medicine 

DISCLAIMER: Nothing contained in this video is intended nor can be taken  to diagnose, treat, or cure any disease. It is for informational purposes only.

This episode is also available as a blog post: https://cureswithoutsideffects.wordpress.com/2021/11/17/cytokines-series-interleukin-12-the-allergy-support-cytokine/

This is the ninth of a series of short videos on Low dose Medicine and in particular Cytokines. This video introduces the cytokine Interleukin 10. IL10 regulates the reactivity of the organism and inhibits the synthesis of most pro- inflammatory cytokines such as IL1, IL6, IL8, IL12, IL23 and tumor necrosis factor (TNF) and also the Th1 sub populations of T-cells such as IFN-gamma and IL2.  IL 10 regulates cell cycles and prevents nitric oxides and oxidative stress, it suppresses metastasis and tumor invasion. Since it inhibits the release of IL 1 and TNF it is able to slow down cartilage erosion. IL-10 can stimulate the synthesis of IgE antibodies and acts synergically with IL 4 to inhibit cell mediated immunity. It also prevents insulin resistance and insulin sensitivity. 

More information about this and other health topics can be found in my books "Low Dose Medicine" and "Cure Without Side effects" by following these links: ►►►https://amzn.to/3Bbx8fd  ►►►https://amzn.to/36iaqDU 

To check the Low dose Medicine health kit follow this link:  ►►►https://kit.co/cureswithoutsideffect/low-dose-medicine 

This episode is also available as a blog post: https://cureswithoutsideffects.wordpress.com/2021/11/12/cytokines-series-interleukin-10-the-master-anti-inflammatory-cytokine/

DISCLAIMER: Nothing contained in this video is intended nor can be taken  to diagnose, treat, or cure any disease. It is for informational purposes only.

This is the eighth of a series of short videos on Low dose Medicine and in particular Cytokines. This video introduces the cytokine Interleukin 7.

More information about this and other health topics can be found in my books "Low Dose Medicine" and "Cure Without Side effects" by following these links: ►►►https://amzn.to/3Bbx8fd

►►►https://amzn.to/36iaqDU

To check the Low dose Medicine health kit follow this link:  ►►►https://kit.co/cureswithoutsideffect/low-dose-medicine

DISCLAIMER: Nothing contained in this video is intended nor can be taken  to diagnose, treat, or cure any disease. It is for informational purposes only.

This is the sixth of a series of short videos on Low dose Medicine and in particular Cytokines. This video introduces the cytokine Interleukin 4. 

More information about this and other health topics can be found in my books "Low Dose Medicine" and "Cure Without Side effects" by following these links: ►►►https://amzn.to/3Bbx8fd  

►►►https://amzn.to/36iaqDU 

To check the Low dose Medicine health kit follow this link:  ►►►https://kit.co/cureswithoutsideffect/low-dose-medicine 

DISCLAIMER: Nothing contained in this video is intended nor can be taken  to diagnose, treat, or cure any disease. It is for informational purposes only.