Particular numbers seem to show up quite a few times in the Bible. Is there anything significant about those numbers? If so, how do we know what they mean?

Scripture Reference: John 17:20-21, Ephesians 4:4, Ephesians 2:16, 2 Cor. 13:14, Ezekiel 1:5-14, Revelation 21:16, Revelation 6:1-8, Revelation 7:1, Matthew 19:28, Revelation 4:4, Revelation 7:3-8, Revelation 12:1, Revelation 21:10-17, Revelation 22:2, Ezekiel 47:12, Revelation 5:5-6, Daniel 7:25, Revelation 13:17-18, Revelation 22:8-9