More phase 3 ubrogepant data published as FDA decision nears

By Jake Remaly

An acute treatment for migraine shows positive results in a phase 3 trial.

Other news:

Gunshot wound victims are at high risk for readmission
Individuals who sustain gunshot wounds have an increased risk for rehospitalization years, and even decades, after their initial injury.

FDA expands use of Toujeo to childhood type 1 diabetes
The new indication includes children as young as 6 years of age.

FDA approves Tula system for recurrent pediatric ear infections
The system can be used in an office setting under local anesthesia.

Higher risk of bipolar disorder, depression, anxiety found with autism
The study supports the importance of early and ongoing surveillance, the researchers said.

You can contact the MDedge Daily Medical News by emailing us at [email protected] or following us on Twitter at @MDedgeTweets.

Quantifying the EHR connection to burnout

By Gregory Twachtman

New research puts a more standard, quantifiable measure to the relationship between EHR usability and burnout.

Other news:

CDC finds that efforts to reduce new HIV infections have stalled
The agency has proposed a federal initiative to improve diagnosis, treatment, and prevention in areas of greatest need throughout the country.

Cardiac arrests peak with pollution in Japan
The incidence of out-of-hospital cardiac arrests in Japan increased on days when counts of particulate matter spiked from the day before.

High recurrence, shortening cycle length in bipolar disorder associated with several biomarkers
The results could lead to research aimed at preventive action.

Naturopaths emphasize role of diet in atopic dermatitis
Allopathic and naturopathic providers diverge in opinions on the role of diet in cause and treatment of AD.

You can contact the MDedge Daily Medical News by emailing us at [email protected] or following us on Twitter at @MDedgeTweets.

Nearly one in five U.S. adolescents have prediabetes

By Bianca Nogrady

Nearly one in five adolescents and one in four young adults in the United States have prediabetes, with a higher prevalence among males.

Other news:

Antibiotic use may increase the risk of Parkinson’s disease

Associations were found for broad-spectrum antibiotics and those that act against anaerobic bacteria and fungi.

2019-2020 flu season starts off full throttle

The five states with the highest activity were Alabama, Georgia, Louisiana, Mississippi, and Texas.

Large state disparities seen for lung cancer screening

In Massachusetts, the rate of lung cancer screening in high-risk individuals is nearly 25 times higher than the rate in Nevada.

AGA releases clinical practice update for pancreatic necrosis

The update includes 15 recommendations based on a comprehensive literature review and the experiences of leading experts.

You can contact the MDedge Daily Medical News by emailing us at [email protected] or following us on Twitter at @MDedgeTweets.

ACGME deepening its commitment to physician well-being, leader says

By Doug Brunk

Positive social relationships with others are crucial to joy and well-being in the practice of medicine.

You can take the MDedge Podcasts survey by clicking here.

Other news:

CMS announces application process for Direct Contracting model

Letters of intent to participate are due by Dec. 10.

ART treatment at birth found to benefit neonates with HIV

Starting antiretroviral therapy within an hour after birth improves immune response.

Certolizumab safety profile varies widely across indications

Systemic corticosteroid use and BMI impact risk of serious adverse events with certolizumab.

Inexperience is the main cause of unsafe driving among teens

Cell phone use nearly doubles the proportion of teen drivers who die in crashes, from 7% to 13%.

You can contact the MDedge Daily Medical News by emailing us at [email protected] or following us on Twitter at @MDedgeTweets.

Managing pain in kids during minor procedures: A tricky balance

By Doug Brunk

Other News:

Supplemental MRI found to benefit women with dense breast tissue

The trial was not large enough to examine the effect of MRI screening on breast cancer-specific or overall mortality.

Late-onset MS is often more severe than earlier-onset MS

Late-onset MS often has faster accrual of disability and might require different treatment options.

DAPA-HF: Dapagliflozin benefits regardless of age, HF severity

The SGLT2 inhibitor had similar efficacy in the elderly, and across the spectrum of baseline symptom status.

Obesity dropping in kids aged 2-4 years in WIC program

During 2010-2016, the prevalence of obesity among this group significantly declined in 73% of U.S. states and territories.

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You can contact the MDedge Daily Medical News by emailing us at [email protected] or following us on Twitter at @MDedgeTweets.

We bring you the best-of Dr. RK, our closing segment of the Psychcast by MDedge. 

Renee Kohanski, MD, a clinical psychiatrist in New England, is the voice and mind behind the Dr. RK segment. 

If you like Dr. RK, you can find more from the Psychcast and from MDedge Psychiatry here. 

In this special Thanksgiving episode, MDedge presents Ilana Yurkiewicz, MD, who is the voice and mind behind the Clinical Correlation segment of Blood & Cancer. 

Clinical Correlation is a segment all about the human side of hematology and oncology care. 

You can find more from Dr. Yurkiewicz and Blood & Cancer, the official podcast of MDedge Hematology/Oncology here.

Atopic dermatitis acts differently in certain populations

By Randy Dotinga

AD may require different treatments depending on age, ethnicity.

You can take the MDedge Podcasts survey by clicking here.

Other news:

Regular use of disinfectants at work associated with increased risk of COPD

Clinicians should look for sources of exposure to cleaning products and disinfectants.

Data build on cardiovascular disease risk after GDM, HDP

Risk factors may be elevated as soon as the first postpartum year.

Survey: Cancer-related pain, opioid use up since 2018

Almost half of patients with cancer did not use anything to manage related symptoms, according to an ASCO poll.

Chronic pain more common in women with ADHD or ASD

Treating patients’ ADHD helps to reduce the pain in some cases.

You can contact the MDedge Daily Medical News by emailing us at [email protected] or following us on Twitter at @MDedgeTweets

OA management guidelines forgo treatment hierarchy or order but emphasize severity, patient risk factors

By Jeff Craven

The guidelines lay out a wide range of treatment options without an algorithm.

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Other news:

Colchicine cut post-MI CVD events

Colchicine fulfilled the promise first seen in CANTOS that anti-inflammatory treatment can reduce cardiovascular disease events.

Large population-based study underscores link between gout, CVD event risk

The relationships between gout and fatal and nonfatal CVD events weren’t weakened by allopurinol use or serum urate lowering to treatment target.

Baseline subtypes predict dementia and death in patients with Parkinson’s disease

Clinicians should assess cognitive and psychiatric symptoms at baseline.

Metformin after gestational diabetes: Lessons from landmark diabetes prevention trial

The drug should be front and center for clinicians who hope to stave off the “remarkable” incidence of type 2 diabetes after GDM.

You can contact the MDedge Daily Medical News by emailing us at [email protected] or following us on Twitter at @MDedgeTweets.

Cannabis frequently is used for endometriosis pain

By Jim Kling

Survey finds more than a third of patients have used marijuana or CBD.

You can take the MDedge Podcasts survey by clicking here.

Other News:

Treating LDL to below 70 reduces recurrent stroke

Patients had fewer events than those with an LDL cholesterol level between 90 and 110.

Geriatric IBD hospitalization carries steep inpatient mortality

A major unmet need exists for better guideline-directed management of geriatric patients hospitalized for IBD.

Two national analyses confirm safety of 9vHPV vaccine

Among 28 million doses delivered since 2015, 7,244 adverse events were reported – an event rate of 1 per 7 million vaccinations.

Early onset of atopic dermatitis linked to poorer control

Children who develop atopic dermatitis in the first 2 years of life are more likely to have poorly controlled or persistent disease.

You can contact the MDedge Daily Medical News by emailing us at [email protected] or following us on Twitter at @MDedgeTweets.