Decoded

Longevity is not luck. It is biology, variation, and human resilience expressed across generations - and we are only beginning to understand it. And few people have studied longevity more deeply than Professor Mayana Zatz, whose work with centenarians and supercentenarians is reshaping what we know about aging.

In this episode of Decoded, Dr. Jurgi Camblong speaks with one of the world’s leading geneticists and a pioneer in rare diseases, aging, and human longevity.

Based at the University of São Paulo, Mayana has followed more than 100,000 families to understand why some people develop severe genetic conditions while others remain healthy into their 90s, 100s, and beyond.

Together, they explore:

• What centenarians and supercentenarians reveal about healthy aging 
• Why some individuals stay healthy despite carrying high-risk mutations
• How genetic resilience may inspire future gene therapies
• What large family cohorts teach us about rare diseases and long-term health
• The role of prevention in the next era of medicine
• Why affordability must be part of the future of genetic treatments

A conversation that brings together genetics, aging research, and the real human stories behind long life. A deeper look at what it means to live longer, and live well.

#Longevity #Genetics #Aging #Centenarians #Supercentenarians #RareDisease #HumanResilience #GeneTherapy #HealthyAging #GenomicResearch #DecodedPodcast

In this episode, Dr. Jurgi Camblong travels to the University of Oxford to meet Professor Nicholas Proudfoot, one of the true pioneers of molecular biology. 

For more than five decades, Nick has helped decode life itself, revealing how genes are turned on and off, how RNA carries meaning beyond proteins, and how curiosity can drive discoveries that last a lifetime. 

Together, they revisit the early days of modern biology - a time before PCR or cloning - and trace how one generation of scientists transformed trial and error into the precision science we know today. 

From the discovery of the AAUAAA “full stop” that signals where genes end, to showing how DNA loops connect beginnings and endings, this is the story of how the foundations of modern genetics were built, one question at a time. 

You’ll hear about: 
 
• The birth of molecular biology, from improvisation to innovation. 
• The hidden power of noncoding RNAs and gene regulation. 
• The beauty and necessity of curiosity-driven research. 
• Why protecting fundamental science matters more than ever. 

Recorded in Oxford, this episode is a love letter to discovery - and to the mentors who remind us that innovation starts with a simple question: why? 

“All great discoveries begin with curiosity. 
If we stop funding curiosity-driven science, 
we stop funding the foundation of tomorrow’s medicine.” 
— Professor Nicholas Proudfoot, University of Oxford

A Conversation with Parminder Bhatia, Chief AI Officer, GE HealthCare

After three episodes with leaders in oncology and medicine - Prof. Malapelle (International Society of Liquid Biopsy), Dr. David Rhew (Microsoft), and Dr. Pedram Razavi (MSK), Jurgi turns to the question everyone’s asking:

How do we move from impressive demos to real impact at the bedside—at scale?

In this episode, Dr. Jurgi Camblong, Founder SOPHiA GENETICS, speaks with Parminder “Parry” Bhatia, Chief AI Officer at GE HealthCare, to unpack the hard parts of AI in medicine: earning clinical trust, fitting into workflows, proving value, and scaling safely across complex systems.

You’ll hear about:

• Adoption as the KPI
• The validation moat - building clinical-grade trust, calibration, and governance.
• Foundation models in imaging
• Real impact of AI in healthcare
• What’s next - agentic AI for tumor-board style decision support, and training clinicians to treat AI like a co-pilot they can question.

If you’re investing in, building, or deploying clinical AI, this is the playbook teams will be sharing. Listen on Spotify or Apple Podcasts.

Cancer has been described for a long time, yet only now are we beginning to truly decode it.

In this episode of Decoded, Dr. Jurgi Camblong, Founder of SOPHiA GENETICS, speaks with Dr. Pedram Razavi, Director of Liquid Biopsy and Cancer Genomics at Memorial Sloan Kettering Cancer Center. 

From the first historical mentions of tumors to today’s breakthroughs in precision oncology, Dr. Razavi shares how genomics, liquid biopsy, and AI are reshaping the way we detect, treat, and even think about cancer. Along the way, Dr. Razavi shares personal stories - the human moments that drive discovery.

In this exciting episode of Decoded, you'll hear:

• The evolving definition of cancer - what makes cancer “selfish,” and why some tumors adapt
• How breast oncology helped pioneer precision medicine
• Why liquid biopsy may let us anticipate resistance before it appears
• The art of oncology: data, science, and the patient in front of you

This conversation bridges history, science, and the future - for clinicians and researchers, patients and families, and anyone who wants to understand how cancer care is changing.

In this episode of Decoded, Dr. Jurgi Camblong, Founder SOPHiA GENETICS, speaks with Dr. David Rhew, Global Chief Medical Officer at Microsoft and adjunct professor at Stanford University, to explore how responsible AI, multimodal data, and collective intelligence are reshaping global healthcare.

From his early fascination with arcade games to his leadership at Microsoft, Dr. Rhew shares a unique journey that blends computer science, clinical practice, and visionary health technology.

Together, they explore:

• Why building trust in AI is fundamental to healthcare transformation
• What multimodal data means for personalized, predictive medicine
• How technology can drive equity and scale across underserved regions
• The cultural and regulatory barriers that still stand in the way

Dr. Rhew also offers timely insights on what the next decade holds for diagnostics, prescribing, and healthcare collaboration - and his advice for the next generation of innovators in technology and medicine.

This is a candid, visionary conversation about the future of care: data-powered, human-centered, and globally connected.

How do we move from discovery to action in the fight against cancer?

In this inaugural episode of the Decoded podcast, Dr. Jurgi Camblong speaks with Professor Umberto Malapelle, one of the leading voices in molecular diagnostics and liquid biopsy, to explore how precision data is reshaping the fight against cancer.

Together, they decode the evolving role of pathology, tracing the shift from glass slides to genomic signals and the rise of liquid biopsy as a dynamic, non-invasive tool in cancer care.

Professor Malapelle reveals how integrating molecular insights is making diagnostics more precise, accessible, and equitable - while empowering clinicians to personalize treatment at scale.

The conversation unpacks the real-world impact of liquid biopsy, the economics of molecular testing, and why the future of cancer care depends on both collaboration and a new generation of digitally fluent healthcare professionals.

Listen in for:

• Insights on where cancer diagnostics is heading
• The power - and challenge - of integrating complex data in medicine
• Why liquid biopsy is more than a buzzword

This is the future of oncology, decoded.

Explore more: https://www.sophiagenetics.com/podcasts/