Finding Peaks

Depression, Neuroplasticity, and Medication Progression


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Episode 46
Depression, Neuroplasticity, and Medication Progression
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Description

In this episode we are joined by Dr. Ashley Johnson, DO to discuss depression and the progression of modern treatment.

Talking Points
  1. Explaining current terms related to modern science such as neuroplasticity and neuromodulation. 
  2. Discussing what has changed in modern treatment for depression and the exciting effects of newer methods.
  3. A mini neuroscience lesson explaining how depression damages neurons and how to help them heal with treatment for depression.
  4. Quotes
    “If you take a thick rope and rub something rough back and forth on it, you’ll see that the fibers start fraying. Those frayed fibers on this rope really represent what your neurons can look like when you have suffered from an untreated mental health condition for quite some time. When they [mental health disorders] go untreated, they actually are assaulting the brain in different areas.”
    -Dr. Ashley Johnson, DO
    Episode Transcripts
    Episode 46 Transcripts

    empathy is knowing your own darkness

    without that connection you don’t have

    anything what’s the opposite of

    addiction just freedom

    well hello everyone uh welcome back to

    another

    episode of finding peaks my name is

    brandon burns chief executive officer

    for peaks recovery centers joined today

    by our chief medical officer

    dr ashley johnson and our chief

    operating officer mr clinton nicholson

    everybody uh

    welcome back everybody who’s joining us

    today as we spoke about on the last time

    i hosted we were going to invite dr

    ashley johnson in to

    talk about a variety of issues

    surrounding patient care in the

    direction of depressive major depressive

    disorders

    we’re going to do what we can to stick

    true to depression as the topic today

    but if you know how this show works if

    you catch us going out in different

    directions

    you already know how it works and for

    those who are new this is how it works

    so

    um so here we are today uh on top of

    this uh not just our chief medical

    officer and i think i just want to

    highlight you know really what that

    means for you know peaks recovery

    centers you

    came into peaks and showed us a variety

    of different ways about how to improve

    patient care not only did you introduce

    um and and bring onboard detox services

    for us so that we could do a continuum

    of care through peaks recovery centers

    but you were really

    the anchor and the flagship for us

    developing integrated care whatsoever

    making mental health primary

    a significant feature of programming and

    creating that inclusion as well as us

    having to kind of punch through the door

    of medication-assisted treatment and

    move through those kind of attitudes at

    the time so

    she’s done an incredible amount of work

    on behalf of peaks recovery centers that

    we are super grateful for

    at the same time as well too

    she’s branched out and created uh

    colorado recovery solutions uh for which

    she’s the ceo and founder of as well too

    and we’ll get into more of what those

    services um include uh in that regard

    but a lot of fantastic things happening

    um that you’re a part of and i think uh

    for the viewers out there as well too um

    you all know me my job here is wanting

    to disrupt an industry and i think uh dr

    ashley johnson here i’m just gonna go to

    dr j because that’s what we call her at

    the office dr j here um is a big part of

    this disruption and i think in a really

    beautiful and vibrant way and so we’re

    going to tackle

    uh these topics today and get right into

    it so

    um through your vision at colorado

    recovery recovery

    recovery solutions um what do you see as

    needing to be disrupted from an industry

    perspective and i’m sure that’s a loaded

    question and maybe there’s a lot to

    dive into there but i think maybe at

    just a high level in a general sense

    what are you seeing

    through the lens of psychiatry

    that is not working for which you

    wish to change moving

    forward i think what i what i see most

    and what drives me the most is what a

    lot of other

    psychiatrists are seeing too

    is it’s just this exciting kind of

    emerging field

    of

    neuroplasticity

    and neuromodulation

    and so that is what really drives uh

    this kind of

    changing the path of our approach um

    so for for decades it was just

    medication we had to wait for the next

    new medic

    new

    mechanism really to come out

    especially with depression

    which is one of the most debilitating

    mental health conditions and

    so we’ve just gone through probably

    every decade since the

    we had a new mechanism of action come

    out and then it wasn’t until the

    ssris

    hit the market that

    in probably around 1990 or so

    was prozac it came out first and then

    zoloft was soon to follow

    and they are amazingly still the

    standard

    first line medication

    however

    what we have also found out over the

    last three decades

    is that you can’t expect full remission

    of symptoms especially with depression

    and ssris are

    first line medication for many different

    psychiatric disorders

    ptsd

    ocd

    generalized anxiety so all of those are

    really kind of top of the list

    that we see

    especially when you come into peaks and

    you know because we have

    now this primary mental health

    i guess kind of track

    it’s not only treating

    someone who has a primary substance use

    disorder but

    we have to think differently about it

    and so because depression is probably

    the most common

    mental health condition

    we are going to see a vast majority of

    primary mental health patients who come

    to peaks for stabilization

    have major depressive disorder

    and so

    it just makes sense that we look at the

    next

    the next best treatment past medications

    and

    that has now emerged as tms

    or transcranial magnetic stimulation and

    i’m glad you said it because i was like

    how do i say tms

    don’t mess it up brandon but you have

    the language so that’s perfect

    it took a lot of practice

    to get that one down

    and then i just went back to calling it

    tms

    so

    it’s a safe place for me too

    so

    i look at the this

    emerging field of

    uh really neuromodulation as kind of

    really two different emerging categories

    and one is tms

    and one is ketamine and

    there’s a couple different forms of

    ketamine now available

    first it was just your basic

    generic ketamine that was first used um

    for anesthesia

    and it’s a it’s a very short acting

    anesthetic dissociative anesthetic and

    um and so for again decades we were

    using it and then just incidentally

    found that it had an extremely potent

    antidepressant effect and so

    then

    practitioners started noticing this and

    and said well why why not just go ahead

    and let’s refine this

    medication

    and

    and give access to the psychiatric

    disorders really people who are

    suffering where we haven’t made a whole

    lot of

    improvement again since the ssris came

    out and then

    that was primarily for depression where

    we saw people really just coming back

    into their own

    after a ketamine

    i guess dosing and then over time we

    also found that through

    understanding the bioavailability of

    ketamine

    is that infusion

    is the best way for people to get

    the best effect and the most exposure

    throughout their body

    from ketamine

    and so that’s why

    for the most part

    if you want a an extremely effective

    version of ketamine therapy you want to

    do infusion and so infusion

    uh i guess if you said

    infusion versus spravato which is the

    nasal spray that’s still that just came

    out a couple years ago

    and is still on patent of course

    is much more difficult to

    access that medication

    um

    but the bioavailability of sprovato as a

    nasal spray

    is it’s it’s actually s ketamine

    um which is just a slight change in the

    chemical makeup

    of it and

    different from

    your just

    basic ketamine

    ketamine is 100 bioavailable

    through infusion

    whereas s ketamine or sprovato

    is 50

    bioavailable through nasal spray

    and so that you can kind of

    associate the differences in its effect

    based on that bioavailability

    so because

    when you deliver that drug through

    the nasal passages

    it has to go through many different

    stages of processing through the body

    where

    it actually degrades it

    whereas infusion can bypass many of

    those kind of filters in your body

    to where you get much more effect from

    it so

    um

    you brought up if you don’t interrupt if

    you brought up two really interesting

    concepts that i think are worth kind of

    mentioning again which uh the idea of

    neuromodulation and neuroplasticity and

    i’m wondering if you could speak to that

    a little bit just for the audience so

    that they recognize because that those

    concepts like you’ve mentioned really

    have sort of changed our approach and

    kind of our understanding of what

    uh the ability or capacity for

    long-lasting change and recovery

    actually really looks like in somebody’s

    day-to-day life um so i’m wondering if

    you could speak to that from the

    psychiatric standpoint what the

    importance of that concept of

    neuroplasticity and neuro modulation

    really is

    yeah absolutely

    so

    really

    it’s not so much that that concept is

    new from medications however it seems

    new because

    these treatments that i’ve mentioned and

    as well as even better understanding

    about

    psychotherapy or talk therapy

    as well as

    your traditional oral medications

    like we mentioned the ssris

    all of those actually have

    an effect on your neuroplasticity if

    done

    correctly

    right uh it’s just some are more

    effective at it than others so that’s

    where tms

    and ketamine come in

    is that they really kind of showed up on

    the stage here

    as

    having a neuromodulatory effect on the

    brain

    that could cause a faster healing

    process basically we were seeing the

    effects faster

    than if you did long-term psychotherapy

    even cbt

    that’s time limited if you did you know

    by the book 12 sessions

    in 12 weeks and then you did occasional

    follow-ups for cbt

    you could see the effects

    similar effects

    if you did six infusions of ketamine

    uh

    in two weeks

    and so

    if now what we’re finding is that the

    the neuromodulatory effect is so much

    more improved if you have a ketamine

    infusion

    or even spravato

    or even oral ketamine while you’re doing

    therapy right so now we’ve combined it

    all and

    while there are lots of therapists out

    there doing that i don’t think we quite

    know yet um the impact of this and how

    positive it’s going to be

    and just so much more effective that’s

    what’s so exciting to me about it

    especially

    absolutely for treatment resistant

    depression

    but especially for ptsd

    in that regard

    yeah i think that you know brandon spoke

    to you um really sort of creating this

    interdisciplinary culture at peaks and

    establishing that through a really

    robust medical program but the it’s the

    integration and sort of the

    collaboration of the clinical world and

    the medical world that where we really

    start to see that where we can have the

    most efficacy as far as change in and

    sort of taking advantage of that the

    sort of neuromodulatory effects of

    treatment and it’s

    what makes this very exciting these

    types of collaborations and the fact

    that there’s this is new

    to a degree you know at least the

    concepts may have been around a while

    but our understanding of them has

    improved our ability to approach them in

    a more in a fresh more um innovative

    fashion is also really improved and then

    when you bring the two worlds together

    you get this sort of um

    exponential impact which we’re just now

    starting to really to kind of explore

    and see what how that works and how that

    engages and really does improve the

    treatment of clients and just quality of

    care in general so it’s pretty um it’s

    it’s an interesting and fun time to be a

    neuro nerd basically it is it is yeah it

    really is absolutely and for me i mean i

    think the brain is the is the new

    frontier it’s the final frontier as far

    as our understanding of of everything

    about us as individuals and how we work

    and how we function and so bringing in

    these kind of new um and uh or or kind

    of more innovative approaches to

    treatment is really exciting

    it is yeah absolutely and and you gave

    um and i’m curious for because i’m

    hearing neuromodulation and

    neuroplasticity and you know at the end

    of the day how how we might be able to

    simplify it through you know a metaphor

    and what that healing mechanism actually

    looks like and you gave uh

    a beautiful presentation and training

    opportunity for staff a few weeks ago as

    well too around the subject and you um

    in describing the neuropathway and what

    was happening i think you brought up the

    metaphor of a rope and it being frayed

    and

    if that still is applicable here and has

    context i would certainly love for you

    to re-review that metaphor on behalf of

    the viewers um so that we can bring

    these con these

    big encyclopedia style terms into you

    know something that’s a little bit more

    palatable yes try to get it down to less

    than five syllables

    in the word uh

    but

    so i love the that metaphor of uh

    if you were to kind of take your

    you know a piece of the brain and kind

    of smush it and you would see all the

    different nerves or even throughout your

    body um

    and in neurons which are kind of long

    and like a rope and so

    what we had talked about was that

    if you take a big rope um like you might

    see it at some

    port somewhere around ships and things

    um and and you just kind of take

    something rough like a brick or or

    whatnot and you just rub it on the rope

    really hard like a hemp rope and

    you’ll start to see the fibers start

    fraying right and so those frayed fibers

    on this rope really represent what your

    neurons

    can look like if you have suffered from

    an untreated mental health condition for

    quite some time like years

    so

    absolutely major depression generalized

    anxiety

    and ptsd and ocd all fit into that

    category they can all really when

    they’re untreated and they go on for

    years

    they actually are assaulting the brain

    in different areas of the brain

    through the different hormone cycles

    that are being released the

    neurotransmitters are

    dysregulated and that kind of thing so

    like all the chemicals and such that are

    swirling around the brain

    they are so disregulated that they’re

    actually assaulting the brain and so

    they will

    those conditions can over time kind of

    almost shrink parts of your brain

    uh again if it’s untreated and so that’s

    why it is so important to

    intervene early in these processes if we

    can you know

    assign the diagnosis figure it out

    through someone’s history

    and then we can come back to what we

    described as this rope

    and by applying even the medications we

    talked about the ssris

    or

    the psychotherapy

    tms

    and ketamine

    when all of those are applied

    appropriately

    those frayed fibers from the rope

    are kind of like smoothed out it’s

    almost like you are

    pouring

    a substance that kind of clears that

    rope off of the yes like a like a wax is

    a good

    good uh analogy as well so then once you

    go and you pour the wax on the rope you

    can’t feel those fibers anymore and

    that’s really what your nerves

    will then look like as they are healing

    if you were to look at them under the

    microscope

    once you have undergone some of these

    treatments right and especially if you

    achieve full remission meaning all of

    your symptoms go away

    and you kind of return to full

    functioning in your life

    i mean the english major me just loves

    the metaphor so yeah yeah yeah

    absolutely

    and

    and as a philosophy major was always

    told not to use metaphors i think i

    think it’s a great metaphor

    in that in that regard as well too um so

    there’s oh there’s so many different

    branches we could fire off from here uh

    on but i think flat out speaking

    somebody comes in with a major

    depressive disorder before we were um as

    a medicalized system or through the lens

    of psychiatris a psychiatry really

    looking at uh these opportunities it was

    just medication right and when it was

    just medication or assuming medication

    moving forward

    um you know there’s a reason in which we

    kind of want to move away from it and

    that reason to me seems to be that there

    isn’t a great uh deal there isn’t a

    significant probability that all

    individuals will get well under

    medication that at some point it feels

    like we’re throwing darts in the dark in

    that regard so

    before diving more into these you know

    unique value propositions that you’ve

    created and brought into colorado

    springs and certainly supported peaks

    patients through

    colorado recovery solutions what is the

    efficacy of medications in the direction

    of

    major depressive disorders at this time

    what we can expect is about 30 percent

    of

    individuals that try

    any one of these first-line medications

    so

    ssris which again is prozac zoloft

    lexapro those are the common ones that

    people are prescribed

    maybe 30 of those people who are

    prescribed those meds will get 30

    improvement in their symptoms of

    depression

    and then it continues down the line

    if if

    prozac zoloft lex pro if it doesn’t work

    standard of care is that you would then

    either try a different ssri or you would

    switch classes of medications and that

    typically in our

    traditional psychiatric

    prescribing world would mean that you

    would go to an snri usually

    is most common and so that would be your

    effexor which is venlafaxin or cymbalta

    which is duloxetine um

    you might somewhere in there try

    wilbutrin which is its own unique

    mechanism it’s a stimulating

    antidepressant and so

    if you have anxiety you don’t typically

    want to use wellbutrin

    but it can be a potent antidepressant in

    and of itself

    and so

    generally speaking you would go down

    that

    kind of algorithm of decision making if

    someone doesn’t respond at any one level

    of that or any treatment there and so

    every time you fail a medication

    generally means that you have less of a

    chance of getting better with a new

    medication

    it’s still worth a try generally

    speaking because medications

    oral medications meaning by mouth

    are

    the side effect profile with ssris and

    snris

    again are all those i just mentioned uh

    they

    the side effect profile is very low

    generally speaking

    um

    at least in regards to if you are

    weighing the risks and benefits of do i

    go on continuing to suffer from

    depression

    or do i try a new medication

    the benefit does outweigh the risk

    of the side effects or even

    the fact that it may not work

    so then um

    so that’s that’s really the cycle we’ve

    been on for

    we didn’t talk about this prior to

    coming on here so uh feel free to just

    say we didn’t talk about this we’re not

    talking about it but it reminds me of

    like when i i think this is how tylenol

    works right let’s say i have a headache

    right because of dehydration i’m not

    aware that i need to drink water but i

    have a headache so

    in american culture one of those quick

    external strategies isn’t to explore hey

    am i did i drink enough water today it’s

    like no i have a headache advil you know

    or thailand all night prescribe that for

    myself over the counter in the moment i

    give it to myself um it’s not clear to

    me that when i take it that i’ve

    actually resolved the core issue that

    the medication is in fact

    at least in the way that i’m perceiving

    it right now is just distracting me from

    the fact that i still have this ongoing

    headache because i have not drank enough

    water

    and if that’s true about how those work

    at least in those moments as a

    distracting feature how much

    do those medications when they’re

    working are

    are they working in a similar way of

    where they’re not actually smoothing out

    the rope in the way that you know

    ketamine infusion and tms is actually

    doing um is it more of a distracting

    feature and it’s still frayed or in time

    is it actually smoothing out that rope

    if all that

    yes that’s a that’s a great question so

    the way i would look at it is

    and what i tell my patients is

    when we’re starting an ssri or an

    antidepressant in general is that this

    is a

    is not just a patch

    it is a neuro regenerative

    medication

    and it if you take it consistently which

    is every day for the most part with all

    of these medications you have to take it

    every day you have to allow your

    body to to reach a steady state of the

    level of the drug

    and then allow it to remain at a steady

    state level for weeks before you will

    get the optimal effect

    on your depression or anxiety and

    during that process

    it is actually stopping the assaultive

    process on your brain’s nerve so it’s

    like taking that brick

    or whatever it was this razor blade that

    that whatever was scraping across this

    rope and fraying it it’s like it’s

    removing that from the process it’s

    putting it’s stopping it but it may it

    may not be

    at least not in the immediate sense it’s

    not

    pouring the wax over the rope to smooth

    it out that takes probably at least a

    year or more

    of you taking the medication

    consistently

    really doing consistent psychotherapy

    so there’s no modulation neuromodulation

    taking place it’s just

    giving it’s taking the brick away and

    then allowing the rope to stay there the

    distracting feature of the medication is

    that i no longer experience the fraying

    the major depression and that sort of

    thing but in time

    uh because we have these natural uh

    cellular you know remodulation that’ll

    take place independent of all these

    things in the background it’s slowly

    healing itself now whereas

    uh

    under the new lens of like ketamine

    infusion for example it’s an immediate

    remodul remodulating of the the the

    neuron there right

    yes uh it still requires uh repetition

    of the infusion

    but

    uh

    and then it still may require boosters

    of the infusion

    uh over

    you know the

    the following year or so

    um

    but it’s quicker and so like with the

    medications the oral medications

    it’s like taking

    if you’re gonna pour wax over the rope

    right it’s like taking a candle a tiny

    little candle that’s burning

    and you do like one drop

    yeah and it

    i mean if you had a rope like as big as

    this room

    that would probably you know could

    easily take a long time yeah a couple

    years easily

    inconsistent therapy and medication to

    achieve the healing that you might

    achieve

    uh through tms or ketamine and so with

    ket well tms actually

    is right now we think that

    you can

    [Music]

    probably achieve

    double the effectiveness of medication

    with a six week actually about more like

    eight week trial

    of treatment with tms

    so speaking of the time frame that it

    takes you know because it

    we have a 45-day residential program in

    which medications are first line of

    defense we usually start those

    immediately however

    seeing the efficacy of those take effect

    is going to take weeks sometimes um and

    we only have six of them right so we

    start the medication right away the

    clinical interventions start right away

    the psychotherapy the sort of

    traditional

    intervention strategy happens right off

    the bat but we know that’s going to take

    time and that really that is the healing

    mechanism at that point it’s

    so

    we have a shortened model we have a

    shortened amount of time and now we have

    these

    new interventions or more

    interventions that have become more

    accessible

    is it appropriate then to start

    ketamine or start tms right off the bat

    in order to kind of almost as a jump

    start to that process does that make

    sense from a medical perspective

    it does and uh i i don’t think of it as

    well if if you look at

    our our detox

    model of care right where it fits in the

    continuum of care for substance use

    disorder treatment

    it’s the first week of treatment about

    right so it’s it’s removing the

    substance

    helping keep someone comfortable

    until they can kind of get back

    to somewhat of their baseline right

    they’re still going to need to go

    through a few weeks of stabilization in

    the residential program

    but having removed

    this the substance that was also

    assaulting the brain

    is stopping that process

    and then we’re kind of in the clear is

    how we look at it medically cleared

    basically to then apply these other

    treatments that are more rapid in their

    effect

    while someone is

    you know participating in the group

    therapy the individual therapy

    especially at peaks and the the model of

    care that we have there

    it’s

    we also can start the the oral

    medication at that time too because

    ketamine

    s ketamine or sprovato tms they all work

    as augmenters of the oral medication as

    well as the psychotherapy

    right and so

    instead of let’s say we have someone who

    comes to us with treatment resistant

    depression and suicidal ideations which

    is pretty common

    in order for them to really

    be able to bypass going to the hospital

    for that to stabilize

    these new treatments especially ketamine

    can help stabilize someone like that so

    that they can continue in the program

    and then with repeated administrations

    of the infusion or sprovato

    it actually is helping propel them into

    healing

    and so it does work

    really seamlessly together and should at

    least now our systems may not our

    financial systems and such i was going

    to might not help us with that a little

    disruptive for a second because knowing

    what we know about the efficacy of these

    treatment interventions and strategies

    the access to them is is does not

    necessarily align with what our

    treatment trajectory would look like

    specifically within this timeline the

    sort of chronological timeline we want

    people in right away and insurance

    companies are not necessarily allowing

    that and i’m just curious want to be

    curious with everybody

    why that is and what we can do within

    our industry and as disruptors of this

    industry to try to change that

    through um

    sort of collaboration with

    organizations like yours and companies

    like yours like crs so as a psychiatrist

    what do you think is our best strategy

    to make

    to make these changes and make them

    known

    so

    i’m uh

    i’m i’m someone who

    my first approach is to just comply

    with whatever they tell me to do

    in order to get my hands on the

    treatment or be able to give access to

    my patients as i just do what they tell

    me to do and

    so

    that’s what i’m doing right now and kind

    of have and just now

    have fulfilled many of these

    requirements

    from insurance companies from the fda

    which you know a lot of those kind of

    things from the fda and what

    what’s bravado is controlled by is

    called a rims program so that stands for

    risk evaluation and mitigation strategy

    and so that’s overseen by the fda the

    dea

    um

    and jansen who created spravato and so

    uh

    we

    in order to

    provide spervato to any given person

    with major treatment resistant major

    depression

    and or acute suicidal ideations we have

    to comply with their program

    in order for the drug to be safely

    administered and not diverted basically

    into the community

    and

    so

    that’s one approach

    [Laughter]

    [Music]

    we encourage that approach yeah sure

    right yes uh safety first absolutely

    absolutely

    truly believe that yeah

    and so uh

    but then come the insurance companies uh

    is so how do you comply with everything

    they want you to because they all have

    different standards

    despite what different interpretations

    of the studies the literature about

    these different treatments and so they

    impose on us

    all their different criteria or i look

    at it as

    what’s that agenda

    yes the almighty dollar

    is always looming in there somewhere so

    so in my approach i learned their game i

    i learn

    basically how do you give access to

    these treatments in their most effective

    manner

    according to

    the evidence that we have for them

    and then how do you advocate to the

    insurance companies

    on the behalf of your patients so that

    when when they’re denied which all of

    these ketamine infusion aside

    it is not covered by any insurance

    because

    many different reasons it’s generic it’s

    been around forever

    there’s no patent for a company to

    really take it and advertise it to

    all these different companies and such

    but

    that is really if you think about it

    while ketamine infusion is invasive in

    that it’s an iv

    um

    effect probably

    potentially

    versus bravado

    should suggest in our culture that you

    know we should be

    supporting this treatment really and

    trying to get

    this one

    out because it’s affordable more

    affordable at least

    than spervato so

    but

    insurance has embraced sprivado

    they they cover that

    but we have to

    of course go through this prior

    authorization

    form for everything that i’ve mentioned

    tms bravado even med management

    at its basic level we have to go through

    these um

    at least

    you know

    figuring out the benefits and such and

    the millions of different plans and such

    and

    but it’s it’s in the times when you you

    spend a lot of time with the patient

    filling out the prior authorization you

    submit it

    um you think it’s a

    slam dunk of a case this person has just

    been suffering for years

    from treatment resistant depression

    you’ve justified all that through all

    the med trials that they’ve gone through

    through the duration of their major

    depressive episode and then um

    it’s possible through some technicality

    that’s written in the insurance um

    policy about tms or academy or spravato

    that they’ll say oh wait no we don’t

    agree with

    that you know

    the overlap of when you tried lexapro

    was one month outside of what you

    documented as the current episode of

    depression and so

    so we don’t count that as a medication

    trial

    and

    you know i think you have to really get

    up

    up to speed on

    all of the literature so that you can

    really you have to kind of go into a

    debate

    with the other physician on the other

    line who is saying no this doesn’t

    qualify i’m going to go ahead and deny

    this and you can just barely keep them

    from hanging the phone up on you

    and then

    if if you do

    get your point across with them

    they still say without any kind of basis

    for it sorry

    we’re just not going to approve this

    today you need to either go to an appeal

    or resubmit it or sorry you’re just out

    of luck so it’s

    that takes hours out of your day

    and the whole time that the patient is

    still suffering absolutely and the risk

    is mounting absolutely for how

    debilitated they may be from their

    depression

    if they’re suicidal yeah you know what

    may happen and these are people who are

    not in the hospital that we’re trying to

    help keep them out of the hospital um

    which ultimately saves insurance

    companies money so there’s this element

    of irony to it all and the thing is

    yeah and i i think i just i i’d like to

    talk about it because this is the world

    in which we live right this is the

    access to care

    that is um

    we we have these new and amazing uh

    intervention strategies at our disposal

    but not necessarily always accessible

    and that is um and that’s frustrating

    and i think it’s valuable to talk about

    it yeah oh a hundred percent and it and

    from uh you know you know my

    frustrations of course and all the

    episodes i’ve done around treatment

    centers websites hope and save and all

    these words have behind it a great deal

    of complexity to actually

    bring the individual forward to which

    now they start feeling hopeful and um

    this is such a wonderful discussion but

    for the sake of time for sure because

    the kids on the social media only have

    so much attention span i think they’ve

    all walked away now

    with the rope analogy so i think we got

    that much across in this moment i just

    wanted to uh before i before i uh take

    us home and uh out of this room uh at

    least for this time until you come back

    with uh jason friesma uh in the

    following week um

    what is

    how long does it take is it neuro uptake

    i forget the language of when you

    take an ssri say you know it’s zoloft or

    lexapro whatever the case might be how

    long does that actually take before the

    individual for the 30 that it may work

    for how long does it take for them to

    actually start experiencing that is it

    immediate is it weeks what can what does

    that look like

    we generally just

    tell people to

    expect

    you know at least four to six weeks

    before you get the max effect of the

    dose that you are currently taking

    you might feel some effect in the first

    week or two

    it’s

    very possible but

    it’s not going to be the full effect

    and then at four to six weeks

    you

    if you don’t have full remission of your

    depression at that time you always want

    to look at what a net would the next

    higher dose be

    uh

    indicated here and usually it is usually

    you just go on up if you haven’t had

    side effects to the to the drug

    and if you have had side effects and

    they’re still going on

    the standard of care is that you have to

    wait that out so you can’t go up on the

    dose

    unless you’re just willing to accept

    that those side effects may get worse

    and then you have to wait it out again

    it can be

    become a very

    strenuous laborious process for any one

    person who’s suffering from depression

    or extreme anxiety even to

    have to wait that out and then

    if it doesn’t work on the first

    go-around to have to do it again

    and then give up if that that one

    doesn’t

    work

    um do have augmenting strategies we can

    try sometimes that does help it kind of

    take control a little bit better

    or take effect

    not all levels of medicine and at least

    practitioners are comfortable doing the

    augmentation strategies with different

    medications but

    so again access to care

    then becomes another risk

    with medications

    and so uh and then access to care

    in regards to tms and and spravato

    is so much more difficult

    to achieve

    then then your risks just continue to

    mount and the suffering continues to

    mount really

    um

    and the vast majority of people

    don’t have

    you know money flowing out of them to

    just kind of yeah pay out of pocket for

    any one of these treatments

    and and for instance bravado

    if you paid out of pocket for that could

    be

    fifteen hundred dollars in

    administration

    and so you could have

    you know it

    easily

    i’m calculating in my head what may be

    the average of someone how many

    administrations someone might have

    uh to actually stabilize on sprovato

    you know at least eight in the first

    few weeks and so

    who can afford that yeah

    absolutely

    they’re already paying for their health

    insurance right so they can barely

    afford that and then it doesn’t um

    oftentimes cover it so yeah it’s a it’s

    a dilemma yeah

    yeah well it i i think that uh so one of

    the things that i just want to challenge

    viewers on especially in relationship to

    addiction treatment centers you know

    even mental health primary centers when

    you get to all of our brilliant websites

    we are stating we treat things like dual

    diagnosis and dual diagnosis as a

    category could be i have a major

    depressive episode taking place right

    now and yeah i was smoking pot six

    months ago or you know maybe engaged in

    some other you know abuse around drugs

    and alcohol but this is the primary

    issue of concern and

    our admissions lines are always so

    passionate to bring people in to be the

    opportunity to be the treatment episode

    that provides these services

    but i think for me and the caution to

    the wind here is is that if our only

    shot at this is to you know dole out

    medications ssris or otherwise that we

    have a fairly limited opportunity to

    actually treat what we say we can treat

    at the end of the day and that really

    resonates with me and calls upon

    treatment providers

    watching this aware of this information

    all around the country

    to proactively

    move in the direction of the creation of

    these advanced services and on top of

    that

    or these services through colorado

    recovery solutions that dr aj has

    brought to

    the community here in colorado springs

    and certainly been supportive of our

    patient demographic coming through

    finding peaks

    uh that

    uh there needs to be these alternatives

    and that

    uh what we can also hear out of this

    discussion is like there is a whole

    insurance side of thing in payment

    platform and a fragmentation that is uh

    right for disruption in this regard in a

    really big way because it is in the way

    of okay now we know meds aren’t going to

    work or it’s going to take four to six

    weeks but the person’s suffering right

    now and how do we get ahead of that in

    this moment so i think it calls upon all

    of us to do a better job to lean into

    these types of

    resources and where we’re going so kind

    of to you know recapitulate what’s going

    on it seems like the problem within

    psychiatry at least in the past has been

    kind of just waiting for the

    pharmaceutical industry to create

    something for us and then to get behind

    it and then hopefully there’s enough

    money behind it for the insurers to come

    in and say okay we’ll provide this

    and that um

    we can’t wait anymore mental health and

    depression and anxiety especially over

    the last two years are just skyrocketing

    exponentially among

    american citizens and certainly around

    the world and so we’re in the need of

    new solutions and through platforms

    such as colorado recovery solutions that

    dr

    jay here has created on behalf of this

    community and is working with peaks

    recovery centers to

    defragment our situation seems like the

    new opportunities and where this is

    headed for which we should all be

    excited about

    but slightly discouraged by um

    the

    amount of time it may take to actually

    get all of this to come together so

    at the end of the day

    thank you so much for coming on and

    talking about this with us it’s a really

    important topic especially around

    depression ptsd

    generalized anxiety there are solutions

    that are out there and available to the

    community and through treatment centers

    like

    peaks but at the end of the day

    the situation is extraordinary and it

    calls upon all of us to do better and to

    have these discussions and to

    represent what the limitations are so

    that people can appreciate why these

    solutions exist and where we’re headed

    as an industry so

    on that note

    as always signing off here at peaks find

    us on finding peaks at peaksrecovery.com

    dr uh johnson here is going to be on uh

    next week’s finding peaks episode as

    well so if there’s more questions

    thoughts ideas that you want to ask in

    her direction uh please let us know

    about that so we can address that at

    that time certainly won’t be the only

    episode i think there’s a we could go on

    for weeks about this uh these topics in

    general uh as you all know chris burns

    is doing awesome fun videos on the tick

    tock follow the peaks recovery tick tock

    page so you can hear loud screams of

    recovery and energy here

    a little bit different than the

    discussions that i’m generally having uh

    again the facebooks the twitters

    you kids all know what’s going on out

    there thanks for being with us and being

    patient as we describe

    these uh technical and detailed uh

    issues that are going on especially

    around depression and until next time

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