Depression is one of the most prevalent mental health conditions worldwide, yet its complexity often makes it challenging to recognize and manage. In this episode, we’ll take a comprehensive look at depressive disorders through the lens of the DSM-5, exploring clinical symptoms, diagnostic criteria, and the spectrum of presentations. We’ll discuss epidemiology, key risk factors, and the critical role of safety and suicide risk assessments in nursing practice. Treatment approaches will be highlighted, including pharmacologic therapies such as SSRIs, SNRIs, and MAOIs, alongside psychotherapeutic and somatic interventions like CBT, ECT, and rTMS. We’ll also cover essential nursing priorities—patient education, monitoring for complications like serotonin syndrome or antidepressant discontinuation syndrome, and providing holistic, individualized care to support recovery and safety.