人や物事に振り回されたりして、もう我慢の限界の達したという時、「もう、うんざり！」と叫びたくなりますね。I’ve had it! は、そんな人や物事と、これ以上関わり続ける意思がないことを表すフレーズです。with ＋人／物事 の形で使うことが多いです。

I’ve had it with someone

I’ve had it with you.

I’ve had it with your ~

I’ve had it with your lies.

I’ve had it with something

I’ve had it with this job – I’m quitting.

I’ve  had it up to here は、ジェスチャーで 首の部分を手で示しながら言います。足の先から始まって、首の所まで我慢が達している、つまりこれ以上（首より上に）行ったら、どうなるかわからないという意味を含んでいます。

例文

父親と息子が夕食のテーブルで話しています

父： ジミー、iPadを切りなさい。夕食を食べながらiPadを使うなって、何回言った？

I’ve had it. From now on, you can clean up after yourself.

I’ve had it. I’m sick and tired of dealing with this problem. You deal with it.

I’ve had it with you. Get out of my face.

I’ve had it with you. Stop complaining and show some appreciation for once.

I’ve had it with all these telemarketing calls. I get them every day.

I’ve had enough of this. I’m outta here.

I’ve had it up to here with your lies. Take a hike.

I’ve had it up to here with my son and his gaming. He just games all the time.

I’ve had it up to here with your rude behaviour. Go to your room.

That’s it. I’ve just about had it with him. One more sly remark, and I’ll knock his head off.