Mike presents the case of a man with painless vision loss and new colorblindness. The retinal exam suggests ischemic vs inflammatory causes. Are acute symptoms always explained by acute diseases?

Dr. Jeffrey Shen presents a perplexing case of a patient with symptoms across nearly all organ systems with some non-specific positive tests but no unifying diagnosis. How can testing characteristics obscure even the most common diagnoses? What does it take to say that a disease has been truly "ruled out?"

Andrew presents the case of a woman with subacute fatigue but no localizing symptoms. On arrival, every lab is flashing red. The diagnosis remains elusive, but seems so obvious in reflection. Can you recognize the illness script?

Mike presents the case of a recently hospitalized man readmitted to the hospital for altered mental status with neuropsychiatric features. The case escalates without a diagnosis until suddenly he's "cured." The only issue? You treated with so many agents simultaneously that now you have no idea which one to keep. Turns out, his nurse holds the final clue.

Mike works through a case of new-onset ascites, where every test comes back negative. Or did they? When we don't know what test to order next, sometimes the best approach is to reconsider the results we already have. What is hiding in plain sight?

Dr Nicholas Salter presents the case of an elderly woman evaluated in the ED for confusion & bradycardia. What if the disease marker can cause the disease itself?

Dr. Brendan Robinson presents a case of refractory shock after recent CABG. As the 4th pressor is hung, Andrew and Mike realize they don't have the "tincture of time" in this one. Join us for an all-out scramble through the shock differential!

Dr. Zaven Sargsyan presents the case of a female patient with the scariest rhythm of them all. The final diagnosis is extremely common, but the path to get there? Let's just say the horses still seem to be wearing their Zebra costumes from Halloween.

"I'm here for my leg, doc" *cough cough*

Grab your RBC inner tube and come flow down the coagulation cascade with us! But let's not forget what lies upstream...