The Fourth Circuit affirmed Lance Wade Cole, Jr.’s conviction for conspiracy to possess with intent to distribute and to distribute fentanyl, acetyl fentanyl, methamphetamine hydrochloride, cocaine, and cocaine base in violation of 21 U.S.C. §§ 841(a)(1), (b)(1)(C), and 846. The court applied a de novo standard of review to the sufficiency of the evidence challenge, upholding the jury’s verdict if substantial evidence supports it when viewed in the light most favorable to the Government. Under this standard, the court assessed whether any rational trier of fact could have found the essential elements of conspiracy beyond a reasonable doubt, specifically requiring proof that the defendant entered an agreement to violate drug laws, had knowledge of the conspiracy, and knowingly participated in it. The court determined that Cole failed to meet his heavy burden of showing evidentiary insufficiency regarding the distinction between a buyer-seller relationship and a conspiracy. The evidence presented at trial demonstrated that Cole acted as a conduit for others by picking up large quantities of drugs for himself and other buyers, such as Gerri Burnham and Millard Engle, based on instructions from the head of the conspiracy, Gary Brown. Additionally, Cole’s direct transactions with Brown involved high quantities and frequent purchases totaling 700 capsules over three weeks in less than four time, which law enforcement testified indicated an intent to redistribute narcotics. The court concluded that these facts, including his role as a middleman and the substantial nature of his purchases, established a sufficient connection to the conspiracy to support the conviction. As a result, the judgment of the District Court for the Northern District of West Virginia is affirmed, and oral argument was dispensed with.