Don't Just Read the Guidelines

On this episode, I talk to David Sutton, consultant haematologist in Stoke-on-Trent about DOACs: indications, pitfalls, levels and more. I loved recording this and it is massively educational.

Here are some links to a few of the resources we talked about.

Anticoagulation forum: Summary of use of DOACs in bariatric surgery and feeding tubes: https://acforum-excellence.org/Resource-Center/resource_files/-2020-05-14-124503.pdf

Sparctool: https://www.sparctool.com/

TRAPS trial – Rivaroxaban vs warfarin for triple positive APLS: https://onlinelibrary.wiley.com/doi/10.1111/jth.15158

ISTH update on use of DOACs in patients with high body weight: https://onlinelibrary.wiley.com/doi/10.1111/jth.15358

Dabigatran vs. warfarin for CVST: RCT: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724157/

On this episode, I talk to Luisa Weiss who is a PhD student in Dublin, Ireland. Luisa's has recently published a very interesting paper in the Journal of Thrombosis and Haemostasis entitled: "Nonvalvular atrial fibrillation patients anticoagulated with rivaroxaban compared with warfarin exhibit reduced circulating extracellular vesicles with attenuated pro-inflammatory protein signatures"

Here, we talk about the paper, further questions, and the clinical implications of her findings.

The paper is available as an open access publication at https://onlinelibrary.wiley.com/doi/10.1111/jth.15434?af=R

Alex is a haematology registrar in Oxford, UK with a strong interest in immunotherapy. He is about to start a PhD on CAR-T cells and talks to me about the future of CAR-T cells, cancer, medicine and research. Follow Alex on Twitter: https://twitter.com/arampotas. Find my free book on CAR-T cells here: https://www.karger.com/Book/Home/280518

Our first ever podcast is an interview with Dr Pip Nicolson, Clinical Lecturer in Haematology at the University of Birmingham. Here, we explore the intricate pathophysiology of vaccine induced thrombotic thrombocytopaenia (VITT).