This sermon encourages believers to overcome internal and external barriers that prevent them from serving God by relying on His power rather than their own abilities. Drawing primarily from John 15:16, the message emphasizes that God has chosen and ordained every Christian for a specific purpose, and provides the Holy Spirit to enable that work. The preacher illustrates this truth by examining biblical figures like Moses, Jacob, Rahab, Samson, and several New Testament saints who were used mightily despite significant personal flaws or past sins. Common hindrances such as laziness, apathy, family obligations, sports distractions, and mental blocks rooted in shame are identified as obstacles to faithfulness. The central call is for believers to surrender their perceived limitations, clean their lives of sin, avoid distractions, and remain willing vessels for God's use.