Plasmalogens are a type of phospholipid found in cell membranes, particularly in the brain, heart, and liver. They are unique in that they contain a vinyl ether bond in the sn-1 position of the glycerol backbone, whereas most phospholipids contain a ester bond in this position. Plasmalogens play important roles in cellular function, including maintaining membrane fluidity and stability, acting as precursors for signaling molecules, and serving as a source of energy for cells. They also have antioxidant properties, helping to protect cells against oxidative stress. Studies have shown that a decrease in plasmalogen levels is associated with several diseases, including Alzheimer's disease, cardiovascular disease, and nonalcoholic fatty liver disease. Researchers are exploring the potential of plasmalogen supplementation as a therapeutic strategy for these and other conditions. Despite their importance, the biosynthesis of plasmalogens is not well understood. Further research is needed to fully understand the role of plasmalogens in health and disease, and to develop effective strategies for restoring plasmalogen levels in individuals with plasmalogen deficiency. Understanding Plasmalogens: Key Components of Cell Membranes Plasmalogens are a type of phospholipid found in cell membranes, playing crucial roles in maintaining cellular function and protecting against oxidative stress. Despite their importance, the biosynthesis of plasmalogens is not well understood and further research is needed to fully comprehend their role in health and disease. What are Plasmalogens? Plasmalogens are unique phospholipids found in cell membranes, particularly in the brain, heart, and liver. Unlike most phospholipids, plasmalogens contain a vinyl ether bond in the sn-1 position of the glycerol backbone. The Importance of Plasmalogens Plasmalogens play several key roles in cellular function, including: Serving as a source of energy for cells Exhibiting antioxidant properties, protecting cells against oxidative stress Plasmalogens and Disease Studies have shown that a decrease in plasmalogen levels is associated with several diseases, including: Alzheimer's disease Cardiovascular disease Nonalcoholic fatty liver disease.

• Plasmalogen deficiency and neuropathology in Alzheimer’s disease: Causation or coincidence? Alzheimer’s & Dementia TRCI 5: Doi 10.1016/j.trci.2019.08.003

2:00 What is a plasmalogen

6:00 White matter tracks

7:26 neuron to neuron signaling

9:06 plasmalogen precursors

9:51 Alzheimer’s and brain reserve capacities

10:22 bio chemical reserve capacity

13:30 having high plasma allergens is a 30 year life expectancy difference

18:00 autism

19:12 MS

20:38 concussions

21:33 omega-3‘s

21:50 omega 9’s

24:40 Why inflammation is a perfect storm and actually feeds upon itself

25:38 rather than trying to suppress the inflammation we want to pull the log out of the fire

29:13 concussions and CTEs

34:15 new advance magnetic resonance imaging called diffuser tensor imaging. Used to measure white matter integrity

Now we can actually measure the water inside the copper wire and the water in the white matter sheath around it and the water outside of that

36:29 your brain never recovers from a concussion it just adapts

38:00 omega nine, and acetylcysteine, carnotine

39:09 in animal studies of brain degeneration, if we pre-treat them with plasmalogen precursors, we can’t actually cause brain damage

42:42 Amaloyd deposition in Alzheimer brains. Related to membrane structure and function

49:24 disease does not take your health away. Your health goes away and disease comes in

50:45 I actually painted a metaphorical analogy that he said he was going to steal!

52:44 function versus biomarkers or having “Tom Brady on the field”

53:50 functionality is the end all

55:00 plasmalogens and cancer

55:46 the Braca protein

58:20 exercise is bad for you. Recovering from exercise is great for you

1:00:30 the reason fasting is so insanely good for us

1: 11:03 What should we eat to help the plasma legend process

1:12:48 importance of membrane structure and

1:15:50 vision back to where it was when he was in his early 20s 1:17:59 the importance of the prodrome scan

1:23:06 his thoughts on intermittent fasting

1:25:02 Gerber sooth

1:26:00 lactobacillus rheuteri

1:31:24 peptides

1:31:35 Dr William Seeds

1:35:49 how a fighter can protect his or her brain before the battle

1:36:2038 APOE4 geno-type and amoloyd plaque

1:37:05 you can neutralize this genotype

1:45:14 Amaloid plaque is actually a biomarker of plasmalogen deficiency

1:45:28 if you have high plasmalogen levels you have low Amaloyd levels

1:45:34 Plasmalogens turn on the turn on Alpha secretase enzyme

1:46:18 HIGH PLASMALOGENS LEVELS NEUTRALIZE THE GENETIC RISK OF THE APOE4 GENOTYPE

1:51:02 neurofibrillary tangles

1:54:46 changing the bio markers without changing the cause Of the biomarker is done across our medical platform and has virtually no long-term clinical benefit

1:55:58 inflammation

2:04:33 his personal progression in medicine, why he dedicated his life to this and his philosophy

2:28:21 Prodrome Sciences