Dr. GPCR Podcast

Dr. Terry Hebert wanted to be a microbiologist. Instead, he ended up getting interested in membrane protein as he followed the biology of a bacterial toxin that affects a mammalian ion channel. Today he and his team are working on understanding receptor signaling in specialized cellular environments to gain a better grasp of receptor function in pathophysiological settings with a special interest in the cardiovascular system. His favorite GPCR is the angiotensin 1 receptor especially for its ability to activate a large variety of signaling pathways. Terry is also very active on social media. With over 2000 followers on Facebook and Twitter, he shares the latest available information on GPCR research daily.

In 1975, Dr. Paul Insel was at the FASEB experimental biology meeting in Atlantic City. During dinner with colleagues and Alfred Gillman, co-recipient of the 1994 Nobel Prize in Physiology or Medicine for their discovery of G-proteins and their role in signal transduction in cells, Paul was designated to go to Gillman’s lab. That summer, he used radioligand binding methods to dissect receptor function from the adenylyl cyclase activated by ligands, including adrenaline. From that point on, Paul was hooked and has since studied receptor function in human physiology, receptor molecular pharmacology in cells, and animal models, and as he puts it has now he’s ‘’gone full circle’’ back to studying GPCRs important in human pathophysiology. Today, Paul and his team focus on previously unrecognized receptors with the hopes to use these as novel drug targets.

In this Episode 0 of the podcast, I, Dr. Yamina Bechiche, your host, and founder of DrGPCR introduce you to the very first podcast dedicated to GPCR researchers and their work.  This podcast is part of the Dr. GPCR Ecosystem.  The goal is to bring us together GPCR scientists, biotech, and pharma leaders as well as suppliers working on GPCRs. We want to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together to accelerate GPCR drug discovery and improve human health. 

For more information visit us at DrGPCR.com/Podcast and join the DrGPCR Ecosystem at DrGPCR.com/Ecosystem. Don't forget to subscribe to our monthly newsletter at DrGPCR.com/Newsletter.