Dr. Howard Smith Reports

Vidcast:  https://youtu.be/eBbOMPnR9Wc

The CPSC and JC Penney now recall Arizona Jean Co. “Lilac Smoke” Girls Midweight Puffer Jackets.  The drawstring inside the bottom lining of this jacket may become caught on playground equipment, handrails, doors or any moving object leading to falls and other child injuries.  About 3700 of these jackets were sold at JC Penney’s stores and online at jcpenney,com.  Don’t let your child wear this garment. Cut and remove the drawstring to eliminate the hazard or contact JCPenney at 800-322-1189 or online at www.jcpenney.com for instructions about returning the jacket for a full refund.

https://www.cpsc.gov/Recalls/2021/JCPenney-Recalls-Girls-Puffer-Jackets-Due-to-Entanglement-Hazard

#jcpenney #girls #jacket #drawstring #entanglement #falls #recall

Vidcast:  https://youtu.be/eBbOMPnR9Wc

The CPSC and JC Penney now recall Arizona Jean Co. “Lilac Smoke” Girls Midweight Puffer Jackets.  The drawstring inside the bottom lining of this jacket may become caught on playground equipment, handrails, doors or any moving object leading to falls and other child injuries.  About 3700 of these jackets were sold at JC Penney’s stores and online at jcpenney,com.  Don’t let your child wear this garment. Cut and remove the drawstring to eliminate the hazard or contact JCPenney at 800-322-1189 or online at www.jcpenney.com for instructions about returning the jacket for a full refund.

https://www.cpsc.gov/Recalls/2021/JCPenney-Recalls-Girls-Puffer-Jackets-Due-to-Entanglement-Hazard

#jcpenney #girls #jacket #drawstring #entanglement #falls #recall

Vidcast:  https://youtu.be/PGWDy-FQbYk

The CPSC and Target are recalling Target Room Essentials Shower Stools.  These shower stools become unstable and slippery when wet and a prone to tipping over leading to falls and other injuries.  About 58,500 of these shower stools were sold in the US at Target and online at target.com.  Stop using this shower stool immediately and return it to your nearest Target store for a full refund.  If you need more information, contact Target at 800-440-0680 daily or check online at www.target.com .

https://www.cpsc.gov/Recalls/2021/Target-Recalls-Shower-Stools-Due-to-Fall-Hazard-Sold-Exclusively-at-Target

#target #showerstool #instability #falls #recall

Vidcast:  https://youtu.be/PGWDy-FQbYk

The CPSC and Target are recalling Target Room Essentials Shower Stools.  These shower stools become unstable and slippery when wet and a prone to tipping over leading to falls and other injuries.  About 58,500 of these shower stools were sold in the US at Target and online at target.com.  Stop using this shower stool immediately and return it to your nearest Target store for a full refund.  If you need more information, contact Target at 800-440-0680 daily or check online at www.target.com .

https://www.cpsc.gov/Recalls/2021/Target-Recalls-Shower-Stools-Due-to-Fall-Hazard-Sold-Exclusively-at-Target

#target #showerstool #instability #falls #recall

Vidcast:  https://youtu.be/oiSbAEfNQto

The CPSC and Trek are recalling the Bontrager Satellite City Bicycle Pedals.  If these pedals are incorrectly installed during bike assembly, they may fall off creating falls and injuries.  About 316,500 of these bicycle pedals were sold in the US and about were sold 28,650 in Canada in Trek stores and online at trek.com.  If you have these pedals, stop using the bicycle and contact your Trek dealer to arrange for a free installation of replacement pedals.  For more information, contact Trek at 800-373-4594 or check online at www.trekbikes.com.

https://www.cpsc.gov/Recalls/2021/Trek-Recalls-Bontrager-Satellite-City-Bicycle-Pedals-Due-to-Fall-and-Injury-Hazards

#trek #pedals #bicycles #falls #recall

Vidcast:  https://youtu.be/oiSbAEfNQto

The CPSC and Trek are recalling the Bontrager Satellite City Bicycle Pedals.  If these pedals are incorrectly installed during bike assembly, they may fall off creating falls and injuries.  About 316,500 of these bicycle pedals were sold in the US and about were sold 28,650 in Canada in Trek stores and online at trek.com.  If you have these pedals, stop using the bicycle and contact your Trek dealer to arrange for a free installation of replacement pedals.  For more information, contact Trek at 800-373-4594 or check online at www.trekbikes.com.

https://www.cpsc.gov/Recalls/2021/Trek-Recalls-Bontrager-Satellite-City-Bicycle-Pedals-Due-to-Fall-and-Injury-Hazards

#trek #pedals #bicycles #falls #recall

Medicine of The Future 4th Week May 2021

Vidcast:  https://youtu.be/cZujrXgN--4

Today’s medical discoveries that point to future therapy.

#Trojanhorse Virus Triggers #Cancer Suicide

#Immunotherapy Aids #PostStroke #Rehab

Enzyme Therapy Stops #Dental #Plaque

#AcidSensing #Bacteria Herald Inflammatory Bowel Disease #IBD

#Microneedle Patch Treats #Skin Infections

3D #Bioprinted #Multiilayer Body Parts

Biochemists at the University of Zurich and CalTech have developed a technique that uses an adenovirus vector similar to that used by the J&J and AstraZeneca CoVid vaccines to convey a self-destructive gene into cancer cells.  Called SHREAD gene therapy, the inserted gene tricks the cancer into producing toxic antibodies that kill it while leaving normal cells untouched.  Its as if cancer-killing drugs are injected into individual cancer cells.

University of Pittsburgh neurologists find that T lymphocytes known as Treg cells play a key role in post-stroke brain healing.  Even better, they use an antigen-antibody complex called IL-2:IL-2Ab that stimulates production of these Treg cells in the brain following a stroke to improve brain function faster and more completely.  It all works in mice, but hopefully, some time soon, it will as well in humans.

Dental plaque in kids forms when bacteria and fungi combine into a sticky mucoid film called biofilms.  Now University of Pennsylvania dentists report that particular enzymes can dissolve and bacterial-fungal bonds, the resultant biofilms, and prevent the formation of damaging plaque.  This enzymatic therapy won’t harm human tissues, and will prevent both tooth decay and gum disease.

Rice University bioengineers developed an otherwise harmless E. coli bacterium that glows or changes colors when it encounters gut acid.  Meanwhile, University of Colorado gastroenterologists show that excess gastrointestinal acid accompanies flare ups of inflammatory bowel disease such as Crohn’s and Ulcerative Colitis and the excess acid likely turns on the genes that trigger inflammation. Combine these findings by adding this acid-sensing, color changing E. Coli in food, and it could discolor toilet water as a sign that a bout of impending bowel inflammation requires proactive therapy.

Nasty skin infections such as those due to methicillin-resistant staph aureus or MRSA usually require intravenous injection of strong antibiotics like vancomycin that have even nastier side effects.  Swedish microbiologists have developed an skin patch composed of vancomycin-impregnated micro-needle arrays that can deliver high concentrations of antibiotic directly to the infected skin without overdosing the entire body.

When traumatic injuries leave gaping holes in the head and face, skin and bone replacements are necessary.  Penn State biomedical engineers have developed complex extrusion and droplet 3D bioprinting techniques using cell and carrier material mixtures in order to print composites of bone and overlying soft tissues at the same time.

These and other cutting edge solutions are coming to your doctor’s office and our hospitals…….some day soon!

https://www.pnas.org/content/118/21/e2017925118

Medicine of The Future 4th Week May 2021

Vidcast:  https://youtu.be/cZujrXgN--4

Today’s medical discoveries that point to future therapy.

#Trojanhorse Virus Triggers #Cancer Suicide

#Immunotherapy Aids #PostStroke #Rehab

Enzyme Therapy Stops #Dental #Plaque

#AcidSensing #Bacteria Herald Inflammatory Bowel Disease #IBD

#Microneedle Patch Treats #Skin Infections

3D #Bioprinted #Multiilayer Body Parts

Biochemists at the University of Zurich and CalTech have developed a technique that uses an adenovirus vector similar to that used by the J&J and AstraZeneca CoVid vaccines to convey a self-destructive gene into cancer cells.  Called SHREAD gene therapy, the inserted gene tricks the cancer into producing toxic antibodies that kill it while leaving normal cells untouched.  Its as if cancer-killing drugs are injected into individual cancer cells.

University of Pittsburgh neurologists find that T lymphocytes known as Treg cells play a key role in post-stroke brain healing.  Even better, they use an antigen-antibody complex called IL-2:IL-2Ab that stimulates production of these Treg cells in the brain following a stroke to improve brain function faster and more completely.  It all works in mice, but hopefully, some time soon, it will as well in humans.

Dental plaque in kids forms when bacteria and fungi combine into a sticky mucoid film called biofilms.  Now University of Pennsylvania dentists report that particular enzymes can dissolve and bacterial-fungal bonds, the resultant biofilms, and prevent the formation of damaging plaque.  This enzymatic therapy won’t harm human tissues, and will prevent both tooth decay and gum disease.

Rice University bioengineers developed an otherwise harmless E. coli bacterium that glows or changes colors when it encounters gut acid.  Meanwhile, University of Colorado gastroenterologists show that excess gastrointestinal acid accompanies flare ups of inflammatory bowel disease such as Crohn’s and Ulcerative Colitis and the excess acid likely turns on the genes that trigger inflammation. Combine these findings by adding this acid-sensing, color changing E. Coli in food, and it could discolor toilet water as a sign that a bout of impending bowel inflammation requires proactive therapy.

Nasty skin infections such as those due to methicillin-resistant staph aureus or MRSA usually require intravenous injection of strong antibiotics like vancomycin that have even nastier side effects.  Swedish microbiologists have developed an skin patch composed of vancomycin-impregnated micro-needle arrays that can deliver high concentrations of antibiotic directly to the infected skin without overdosing the entire body.

When traumatic injuries leave gaping holes in the head and face, skin and bone replacements are necessary.  Penn State biomedical engineers have developed complex extrusion and droplet 3D bioprinting techniques using cell and carrier material mixtures in order to print composites of bone and overlying soft tissues at the same time.

These and other cutting edge solutions are coming to your doctor’s office and our hospitals…….some day soon!

https://www.pnas.org/content/118/21/e2017925118

https://www.cell.com/immunity/fulltext/S1074-7613(21)00184-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761321001849%3Fshowall%3Dtrue

https://mbio.asm.org/content/12/3/e00651-21

https://www.pnas.org/content/118/20/e2023871118

https://onlinelibrary.wiley.com/doi/10.1002/admt.202001307

https://onlinelibrary.wiley.com/doi/10.1002/adfm.202010858

Vidcast:  https://youtu.be/iWz4PaDr3gM

Two doses of the Moderna mRNA vaccine prevent 100% of CoVid infections in adolescents 12 to 18 years of age.  The company just announced the results of its phase 1-2 study in preparation for submission to the FDA in June seeking an Emergency Use Authorization.

A total of 3,732 teens were randomized 2 to 1 to receive the vaccine.  CoVid infection prevention efficiency was 93% two or more weeks after even the first dose.  The side effects of the vaccine were mild to moderate in severity and comparable to those seen in adults.

Moderna and Pfizer are both conducting vaccine trials with infants, toddlers, and younger children using a range of test doses.

https://investors.modernatx.com/news-releases/news-release-details/moderna-announces-teencove-study-its-covid-19-vaccine/

#moderna #CoVid #vaccine #teens #adolescents

Vidcast:  https://youtu.be/iWz4PaDr3gM

Two doses of the Moderna mRNA vaccine prevent 100% of CoVid infections in adolescents 12 to 18 years of age.  The company just announced the results of its phase 1-2 study in preparation for submission to the FDA in June seeking an Emergency Use Authorization.

A total of 3,732 teens were randomized 2 to 1 to receive the vaccine.  CoVid infection prevention efficiency was 93% two or more weeks after even the first dose.  The side effects of the vaccine were mild to moderate in severity and comparable to those seen in adults.

Moderna and Pfizer are both conducting vaccine trials with infants, toddlers, and younger children using a range of test doses.

https://investors.modernatx.com/news-releases/news-release-details/moderna-announces-teencove-study-its-covid-19-vaccine/

#moderna #CoVid #vaccine #teens #adolescents