Dr. Howard Smith Reports

Vidcast:  https://youtu.be/OnuvfszO7kE

One hallmark of successful cancer immunotherapy is the deployment of checkpoint inhibitors, antibodies against the PD-1 receptors on lymphocytes that prevent them from killing cancer cells.  These must be repeatedly infused intravenously to trigger the army of killer white cells.

A just published study from Ohio State shows that even more powerful checkpoint antibodies may be synthesized using an immunogenic peptide PD1-Vaxx.  The vaccine prompts production of multiple antibodies to multiple sites on the PD-1 receptor.

This vaccine shows significant anti-cancer activity in a mouse human colon cancer model.  It remains to future studies to test it on humans.  This vaccine could also induce anti-cancer surveillance preventing emergence of tumors.

https://www.tandfonline.com/doi/full/10.1080/2162402X.2020.1818437

#cancer #vaccine #checkpoint #pd1

Vidcast:  https://youtu.be/OnuvfszO7kE

One hallmark of successful cancer immunotherapy is the deployment of checkpoint inhibitors, antibodies against the PD-1 receptors on lymphocytes that prevent them from killing cancer cells.  These must be repeatedly infused intravenously to trigger the army of killer white cells.

A just published study from Ohio State shows that even more powerful checkpoint antibodies may be synthesized using an immunogenic peptide PD1-Vaxx.  The vaccine prompts production of multiple antibodies to multiple sites on the PD-1 receptor.

This vaccine shows significant anti-cancer activity in a mouse human colon cancer model.  It remains to future studies to test it on humans.  This vaccine could also induce anti-cancer surveillance preventing emergence of tumors.

https://www.tandfonline.com/doi/full/10.1080/2162402X.2020.1818437

#cancer #vaccine #checkpoint #pd1

Vidcast:  https://youtu.be/tCbUg5H-sy4

Cornell neuroscientist Dr. Lisa Mosconi has identified brain and body differences between the two genders.  Parade magazine encapsulated her findings this past weekend.

Women:

• See doctors more often
• Benefit more from plant-based diets
• Have greater risks of dementia
• Experience more anxiety and depression
• Suffer more headaches and migraines 
• Have more autoimmune diseases

Men:

• Develop illness at younger ages
• Experience more lifetime illness
• Die younger
• Have higher healthcare costs
• Have more gout
• Have more inguinal hernias
• Suffer more aortic aneurysms
• Develop more kidney stones
• Have more alcoholism
• Develop more duodenal ulcers
• Suffer more emphysema

Know your risks and improve your chances.

https://parade.com/1121927/paulaspencer/how-mens-womens-brains-different/

#health #men #women

Vidcast:  https://youtu.be/tCbUg5H-sy4

Cornell neuroscientist Dr. Lisa Mosconi has identified brain and body differences between the two genders.  Parade magazine encapsulated her findings this past weekend.

Women:

• See doctors more often
• Benefit more from plant-based diets
• Have greater risks of dementia
• Experience more anxiety and depression
• Suffer more headaches and migraines 
• Have more autoimmune diseases

Men:

• Develop illness at younger ages
• Experience more lifetime illness
• Die younger
• Have higher healthcare costs
• Have more gout
• Have more inguinal hernias
• Suffer more aortic aneurysms
• Develop more kidney stones
• Have more alcoholism
• Develop more duodenal ulcers
• Suffer more emphysema

Know your risks and improve your chances.

https://parade.com/1121927/paulaspencer/how-mens-womens-brains-different/

#health #men #women

Vidcast:  https://youtu.be/FopRSkMu_F8

If your child has a tonsillectomy, don’t use ibuprofen, Motrin or Advil, to control post-operative pain.  A study from Harvard’s Boston Children’s Hospital shows that these drugs increase the risk of bleeding following tonsillectomy by 36%.

The study analyzed more than one-half million children under 18 years who underwent tonsil removal between 2004 and 2015.  Another NSAID, ketoralac, a non-steroidal anti-inflammatory drug often used in the recovery room, increased the bleeding risk by nearly 40%.

How do you then help your kid get through recovery.  Use acetaminophen, Tylenol, every 4 hours and give them plenty of sugar.  I put my tonsillectomy patients on the Twinkie diet since sugar does damp pain.

https://journals.sagepub.com/doi/full/10.1177/0194599820970943

#bleeding #tonsillectomy #ibuprofen #nsaids

Vidcast:  https://youtu.be/FopRSkMu_F8

If your child has a tonsillectomy, don’t use ibuprofen, Motrin or Advil, to control post-operative pain.  A study from Harvard’s Boston Children’s Hospital shows that these drugs increase the risk of bleeding following tonsillectomy by 36%.

The study analyzed more than one-half million children under 18 years who underwent tonsil removal between 2004 and 2015.  Another NSAID, ketoralac, a non-steroidal anti-inflammatory drug often used in the recovery room, increased the bleeding risk by nearly 40%.

How do you then help your kid get through recovery.  Use acetaminophen, Tylenol, every 4 hours and give them plenty of sugar.  I put my tonsillectomy patients on the Twinkie diet since sugar does damp pain.

https://journals.sagepub.com/doi/full/10.1177/0194599820970943

#bleeding #tonsillectomy #ibuprofen #nsaids

Vidcast:  https://youtu.be/8alCgy0cR3A

Antibodies against the mumps virus appear to have CoVid protective effects.  A study just published by mBio looked at a group of 80 COVID patients, 50 of whom had been vaccinated with MMR II vaccine vs an unvaccinated group.

Those with antibodies against the mumps virus, an RNA virus like CoVid, suffered less severe disease than those without mumps antibodies or low concentrations or titers of them.  The severity of disease was proportional to mumps antibody titer: the asymptomatic had titers of 134-300; mild symptoms below 134; moderate symptoms below 75, and severe symptoms below 32.

Vaccination with MMR and other vaccines may be keeping nearly half of CoVid test positive persons apparently healthy.

https://mbio.asm.org/content/11/6/e02628-20

#covid #mmr

Vidcast:  https://youtu.be/8alCgy0cR3A

Antibodies against the mumps virus appear to have CoVid protective effects.  A study just published by mBio looked at a group of 80 COVID patients, 50 of whom had been vaccinated with MMR II vaccine vs an unvaccinated group.

Those with antibodies against the mumps virus, an RNA virus like CoVid, suffered less severe disease than those without mumps antibodies or low concentrations or titers of them.  The severity of disease was proportional to mumps antibody titer: the asymptomatic had titers of 134-300; mild symptoms below 134; moderate symptoms below 75, and severe symptoms below 32.

Vaccination with MMR and other vaccines may be keeping nearly half of CoVid test positive persons apparently healthy.

https://mbio.asm.org/content/11/6/e02628-20

#covid #mmr

Vidcast:  https://youtu.be/g6wn4vZ2oaw

The few unlucky persons who test COVID positive after recovering from the virus appear not to be spreaders. This conclusion comes from a Wuhan, China study that reviewed the records of 20,280 COVID patients from December through August.  The researchers also surveyed their close contacts numbering 4,079.

The data show that 12% of the group were CoVid+ repeaters.  These patients were representative of the group initially infected except that they tended to require 3 day longer hospitalizations and a greater proportion of females were repeaters.

None of their close contacts developed positive CoVid PCR tests.  The investigators suggest that these “echo” positives may occur due to residual circulating non=infectious viral remnants.

 https://www.medrxiv.org/content/10.1101/2020.11.18.20232892v1.full.pdf

#covid #repeatpositive

Vidcast:  https://youtu.be/g6wn4vZ2oaw

The few unlucky persons who test COVID positive after recovering from the virus appear not to be spreaders. This conclusion comes from a Wuhan, China study that reviewed the records of 20,280 COVID patients from December through August.  The researchers also surveyed their close contacts numbering 4,079.

The data show that 12% of the group were CoVid+ repeaters.  These patients were representative of the group initially infected except that they tended to require 3 day longer hospitalizations and a greater proportion of females were repeaters.

None of their close contacts developed positive CoVid PCR tests.  The investigators suggest that these “echo” positives may occur due to residual circulating non=infectious viral remnants.

 https://www.medrxiv.org/content/10.1101/2020.11.18.20232892v1.full.pdf

#covid #repeatpositive