Dr. Howard Smith Reports

Vidcast:  https://youtu.be/NQxpwpddiYs

Those pretzels, chips, and pasta sauce may weaken your immune defenses against bacteria and viruses including CoVid19.  Immunologists at Germany’s University of Bonn trace the effects of your liberal self-shaking on your host defenses.

When you eat abundant salt, your kidneys seek to flush it out to maintain a safe concentration around your cells.  In so doing, glucocorticoid steroid levels in your body rise, and these steroids suppress your immunity.  Their studies in both mice and men confirm this effect.

Given our current coronavirus epidemic, you can’t afford to given an advantage to invading viruses or bacteria.  Cut out the salty foods and gorge on fruits and vegetables as you social distance. 

Katarzyna Jobin, Natascha E. Stumpf, Sebastian Schwab, etal. A high-salt diet compromises antibacterial neutrophil responses through hormonal perturbation. Science Translational Medicine, 2020 DOI: 10.1126/scitranslmed.aay3850

#covid19 #coronavirus #salt #immunity

Vidcast:  https://youtu.be/NQxpwpddiYs

Those pretzels, chips, and pasta sauce may weaken your immune defenses against bacteria and viruses including CoVid19.  Immunologists at Germany’s University of Bonn trace the effects of your liberal self-shaking on your host defenses.

When you eat abundant salt, your kidneys seek to flush it out to maintain a safe concentration around your cells.  In so doing, glucocorticoid steroid levels in your body rise, and these steroids suppress your immunity.  Their studies in both mice and men confirm this effect.

Given our current coronavirus epidemic, you can’t afford to given an advantage to invading viruses or bacteria.  Cut out the salty foods and gorge on fruits and vegetables as you social distance. 

Katarzyna Jobin, Natascha E. Stumpf, Sebastian Schwab, etal. A high-salt diet compromises antibacterial neutrophil responses through hormonal perturbation. Science Translational Medicine, 2020 DOI: 10.1126/scitranslmed.aay3850

#covid19 #coronavirus #salt #immunity

Vidcast:  https://youtu.be/98zOq9ZpG9M

TPA, the clot busting tissue plasminogen activator that rescues heart attack and stroke patients, may help ventilator-dependent CoVid19 patients in respiratory failure.  Researchers at MIT, Harvard teaching hospitals, and the University of Colorado believe that TPA can prevent extensive blood clotting that exacerbates CoVid19 patients’ respiratory failure.

Clinicians on the front lines of the coronavirus battle in New York and Europe report that infected patients clot too easily and have damaging clots not only in their lungs but also in their hearts and kidneys as part of multi-organ failure.

A federally-funded clinical trial of TPA will deliver the drug intravenously and via direct airway instillation.  Genentech is donating the drug. 

Hunter B. Moore, Christopher D. Barrett, Ernest E. Moore, Robert C. McIntyre, Peter K. Moore, Daniel S. Talmor, Frederick A. Moore, Michael B. Yaffe. Is There a Role for Tissue Plasminogen Activator (tPA) as a Novel Treatment for Refractory COVID-19 Associated Acute Respiratory Distress Syndrome (ARDS)? Journal of Trauma and Acute Care Surgery, 2020; 1 DOI: 10.1097/TA.0000000000002694

#covid19 #coronavirus #tpa #respiratoryfailure #clotting

Vidcast:  https://youtu.be/98zOq9ZpG9M

TPA, the clot busting tissue plasminogen activator that rescues heart attack and stroke patients, may help ventilator-dependent CoVid19 patients in respiratory failure.  Researchers at MIT, Harvard teaching hospitals, and the University of Colorado believe that TPA can prevent extensive blood clotting that exacerbates CoVid19 patients’ respiratory failure.

Clinicians on the front lines of the coronavirus battle in New York and Europe report that infected patients clot too easily and have damaging clots not only in their lungs but also in their hearts and kidneys as part of multi-organ failure.

A federally-funded clinical trial of TPA will deliver the drug intravenously and via direct airway instillation.  Genentech is donating the drug. 

Hunter B. Moore, Christopher D. Barrett, Ernest E. Moore, Robert C. McIntyre, Peter K. Moore, Daniel S. Talmor, Frederick A. Moore, Michael B. Yaffe. Is There a Role for Tissue Plasminogen Activator (tPA) as a Novel Treatment for Refractory COVID-19 Associated Acute Respiratory Distress Syndrome (ARDS)? Journal of Trauma and Acute Care Surgery, 2020; 1 DOI: 10.1097/TA.0000000000002694

#covid19 #coronavirus #tpa #respiratoryfailure #clotting

Vidcast:  https://youtu.be/q66mLjoY-r4

Tocilizumab, a Genentech-Roche drug marketed as Actemra for autoimmune arthritis and cytokine storms induced by CAR-T cell cancer therapy, did successfully squelch CoVid19 immune storm in a preliminary Chinese study.  Researchers there treated 20 patients with severe and critical disease in risk of dying.

The patients received a 9 day course of the drug along with vent therapy.  75% showed improved oxygenation and one patient came off oxygen and 90% showed improved lung CTs. 90% of patients with discharged well.

 A worldwide clinical trial coded as COVACTA will begin recruiting 330 patients in April.  The drug, potentially lifesaving, does have serious side effects including gastrointestinal tears, liver toxicity, and cancer

http://chinaxiv.org/abs/202003.00026

https://www.cancernetwork.com/news/fda-approves-phase-iii-clinical-trial-tocilizumab-covid-19-pneumonia

#covid19 #coronavirus #cytokinestorm #covacta #actemra #tocilizumab

Vidcast:  https://youtu.be/q66mLjoY-r4

Tocilizumab, a Genentech-Roche drug marketed as Actemra for autoimmune arthritis and cytokine storms induced by CAR-T cell cancer therapy, did successfully squelch CoVid19 immune storm in a preliminary Chinese study.  Researchers there treated 20 patients with severe and critical disease in risk of dying.

The patients received a 9 day course of the drug along with vent therapy.  75% showed improved oxygenation and one patient came off oxygen and 90% showed improved lung CTs. 90% of patients with discharged well.

 A worldwide clinical trial coded as COVACTA will begin recruiting 330 patients in April.  The drug, potentially lifesaving, does have serious side effects including gastrointestinal tears, liver toxicity, and cancer

http://chinaxiv.org/abs/202003.00026

https://www.cancernetwork.com/news/fda-approves-phase-iii-clinical-trial-tocilizumab-covid-19-pneumonia

#covid19 #coronavirus #cytokinestorm #covacta #actemra #tocilizumab

Lindt Excellence 85% Cocoa Chocolate Recalled

Vidcast:  https://youtu.be/SlUff4Zowzs

Lindt and Sprüngli USA is voluntarily recalling its Lindt Excellence 85% Cocoa chocolate bars due to improper packaging and labeling.  The product in the wrapper is actually Lindt Excellent Dark Carmel Sea Salt bars.  This contains milk and soy.  Those who have allergies to either may develop and allergic reaction that could be life-threatening.  The Lot is Code L5539 with a best before date of 11/30/2020.  If you have this product, return it to any Lindt store for a replacement.

https://bit.ly/2J6nTmH

#recall #lindt #chocolate #milk #soy

Lindt Excellence 85% Cocoa Chocolate Recalled

Vidcast:  https://youtu.be/SlUff4Zowzs

Lindt and Sprüngli USA is voluntarily recalling its Lindt Excellence 85% Cocoa chocolate bars due to improper packaging and labeling.  The product in the wrapper is actually Lindt Excellent Dark Carmel Sea Salt bars.  This contains milk and soy.  Those who have allergies to either may develop and allergic reaction that could be life-threatening.  The Lot is Code L5539 with a best before date of 11/30/2020.  If you have this product, return it to any Lindt store for a replacement.

https://bit.ly/2J6nTmH

#recall #lindt #chocolate #milk #soy

Vidcast:  https://youtu.be/Qh5-66RULws

Mountain Rose Herbs is voluntarily recalling its Organic Kudzu Root Herbal Supplement.  This product may have Salmonella contamination.  This bacterium can product a severe gastroenteritis or get into the bloodstream and induce sepsis with heart valve infection, blood vessel infection, or septic arthritis.  The Lots involved are #24247-X and #24247.  This product has been sold in nearly every state and in Canada.  If you have this item, return it to the place of purchase for a full refund.  Info from the company at 1-800-879-3337.

https://www.fda.gov/safety/recalls-market-withdrawals-safety-alerts/mountain-rose-herbs-recalls-organic-kudzu-root-herbal-supplement-due-possible-health-risk

#recall #kudzuroot #supplement #salmonella

Vidcast:  https://youtu.be/Qh5-66RULws

Mountain Rose Herbs is voluntarily recalling its Organic Kudzu Root Herbal Supplement.  This product may have Salmonella contamination.  This bacterium can product a severe gastroenteritis or get into the bloodstream and induce sepsis with heart valve infection, blood vessel infection, or septic arthritis.  The Lots involved are #24247-X and #24247.  This product has been sold in nearly every state and in Canada.  If you have this item, return it to the place of purchase for a full refund.  Info from the company at 1-800-879-3337.

https://www.fda.gov/safety/recalls-market-withdrawals-safety-alerts/mountain-rose-herbs-recalls-organic-kudzu-root-herbal-supplement-due-possible-health-risk

#recall #kudzuroot #supplement #salmonella