Vidcast: https://youtu.be/3aNsAmXBDFc
Today’s newly announced medical discoveries that point to future therapy:
Lab on a chip offers speedy heart attack diagnosis
Better vaccine immunity from a skin patch than a jab
Steerable catheters to deliver brain therapy
And finally, a tissue glue based on barnacles
It currently takes hours to confirm the heart muscle damage diagnostic of a heart attack. Bioengineers at Notre Dame working with cardiologists at the University of Florida now report a 30 minute, ultra-sensitive membrane-based test to detect the microRNAs that confirm a heart attack diagnosis. Their system uses tiny amounts of blood, can distinguish the cardiac muscle changes due to lack of oxygen from so-call re-perfusion changes, and is portable. It may provide a life-saving resource to areas far from cardiac cath facilities.
A 3D printed vaccine patch invokes a 10-fold stronger immune response compared with delivery of the same vaccine into the arm muscle. This from a University of North Carolina study that used a patch of microneedles fabricated by a 3D printing process called continuous liquid interface production or CLIP. The investigators showed that this carpet of microneedles triggers enhanced antibody production and cell-mediated immunity in a relatively non-invasive manner.
UC-San Diego investigators have developed steerable catheters tiny enough to navigate the smaller blood vessels of the deep brain. They achieved the result by mimicking the micro-hydraulics of insect legs by casting layers of silicone with different levels of stiffness. The catheters are bent by pressurized saline, and they have been successfully deployed during neurosurgery on pigs.
And finally, from MIT comes a novel tissue glue inspired by the sticky substances used by barnacles to attach to rocks. This adhesive is unique since it works on surfaces covered with blood making it useful for sealing tissues with open blood vessels. It consists of the polymer polyacrylic acid, an NHS ester, and the sugar chitosan. The trio are mixed, frozen into sheets, ground into microparticles, and then suspended in medical grade silicon oil. The adhesive will set and stop any bleeding within 15-30 seconds after application.
These and other cutting edge solutions are coming to your doctor’s office and our hospitals…….some day soon!
https://pubs.rsc.org/en/content/articlelanding/2021/LC/D1LC00685A
https://www.pnas.org/content/118/39/e2102595118
https://www.sciencedaily.com/releases/2021/08/210819113048.htm
https://www.nature.com/articles/s41551-021-00769-y
#heartattack #microRNA #labonachip #microneedles #vaccination #catheter #brain #steerable #glue #bleeding #barnacles