This week's guest is Dr. Yaakov Stern, Florence Irving Professor of Neuropsychology at Columbia University Medical Center. Dr. Stern and Brent discuss the science and lived reality of Alzheimer's disease and dementia. They talk about what distinguishes normal cognitive aging from dementia, how biomarkers like amyloid and tau shape diagnosis, and why new drugs may slow the disease. Dr. Stern shares insights from decades of research on cognitive reserve, prevention, and lifestyle factors such as sleep, exercise, and social engagement that can delay onset or lessen severity. Hope you enjoy.