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I'd deeply appreciate your help and, ideally, mobilizing your networks and those closest to you to also participate. This is crucial for animals in the EU and globally, as the European market shapes global trade. It's boring and - yes, it's one of the many to come - but you need to win battles to win the war. :)
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Getting started (the easy part)
When I first encountered the biosecurity space in 2023, after reading former Soviet scientist Ken Alibek's memoir, I was immediately drawn to the idea of fighting infectious disease threats that had tormented human civilization for years. I had barely any experience with biology (I had taken one pandemic-era class and skipped taking AP Bio) and would consider myself more of a policy wonk than a STEM nerd. But compelling arguments about the neglectedness, tractability, and impact that biosecurity work could have on the world convinced me that it was critical for many people to be working on this issue. Over time, I began to see myself as one of those people.
Today, there are more resources than ever before to introduce people to biosecurity and give them context over the problems and solutions in the field. Many people I know have started with BlueDot Impact's Biosecurity course, resources from 80,000 Hours, and a number of great books and articles that can help students as young as high school tackle these concepts confidently.
After browsing the biosecurity ‘curriculum’, there are a number of ways to get involved and start to work on concrete projects. Programs [...]
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Outline:
(00:11) Getting started (the easy part)
(02:33) A reality check
(06:22) The bar for impact is high
(09:45) What (most) young people actually need to hear
(11:17) Moving forward
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1Day Sooner advocates on behalf of people who join medical studies for altruistic reasons. We focus particularly on “challenge studies,” where participants are exposed to pathogens to develop vaccines and learn about infectious disease. We work at three levels: trials, technologies, and policies. Our best analysis of our knowable causal impact through summer of 2024 can be found here. We believe we have a strong opportunity to generate millions of dollars in funding for hepatitis C vaccine development for $50-200K.
This year, we expanded our trials work by launching our “Cooperative Participant Organization,” which provides support to trial teams working on high-value infectious disease research. This has expanded our trial support work from our previous focus on hepatitis C challenge studies to cover enteric, parasitic, and other hepatic trials.
But expanding our trials work has opened up a gap in advancing hepatitis C vaccine technologies, since the team that previously covered both trials and hepatitis C vaccines now have a wider range of responsibilities. We have an opportunity that we think could lead to >$10M in funding from the NIH for hepatitis C vaccine development (including hepatitis C challenge studies), but we currently do not have the staffing to [...]
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In low- and middle-income countries, millions of women want to plan their families but face stigma or lack access to reliable information. Over 100 million unintended pregnancies occur yearly, contributing to tens of thousands of maternal deaths.
To enable informed family planning, FEM produces evidence-driven, regionally tailored radio campaigns. Our content addresses misinformation and stigma with storytelling, Q&A shows, and programmes with religious and health authorities.
Read Rethink Priorities’ evaluation of FEM's work here.
After a pilot in 2021, FEM conducted 16 months of campaigning in Kano, Nigeria, in collaboration with the Ministry of Health. We have since conducted proofs of concept (POCs) in 11 more Nigerian states and three more countries.
In the past year, FEM and its partners:
Our funding gap for this giving season is 1.1 million USD, for work in Nigeria, Niger, and Benin. This figure reflects our goal [...]
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TLDR: DMI is looking for $1,269,000 to scale our child survival projects nationally in Uganda ($765,000) and Mozambique ($504,000), to save over 4,500 under-five lives annually.
DMI Overview
Hi everyone, I’m Alex. I’m a Project Development Officer writing on behalf of Development Media International (DMI). This marginal funding week, DMI is looking to close the funding gap for our national-scale, cost-effective child survival campaigns in Uganda and Mozambique.
DMI runs large-scale mass media campaigns to create informative and engaging programming that focuses on shifting health behaviours to reduce maternal and childhood mortality. DMI develops and delivers live-saving campaigns at scale, reaching over 70 million people in the last quarter. Our messages primarily focus on prevention and treatment-seeking for the three most common preventable causes of death of children under the age of five: malaria, pneumonia and diarrhoea. Treatments for these diseases are readily available, effective and usually free at point of need, so children who are taken for prompt treatment have a high chance of survival. We measure our impact using modelled lives saved of children under the age of five.
DMI has conducted two large-scale randomised control trials that have provided gold-standard evidence for our campaigns’ effectiveness (see [...]
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TL;DR
Who We Are
Why These Areas Are Neglected and Important
Across animal advocacy, several leverage points remain under-addressed:
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Outline:
(00:15) TL;DR
(01:06) Who We Are
(01:51) Why These Areas Are Neglected and Important
(03:06) Our 2026 Plans
(03:10) 1. AI & Animals Documentary Dissemination
(03:46) 2. Wild Animal Suffering Documentary
(04:19) 3. Seantience: Aquatic Animal Sentience Campaign
(05:02) Our Funding Gap
(05:21) What impact your donation would have?
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What is the ECF?
Longview operates a public fund: the Emerging Challenges Fund. It is focused on global catastrophic risks from emerging technology such as AI. We recently released our 2025 ECF Annual Report, which provides a top-level overview of the fund and grants made in 2025.
Through the ECF, we offer anyone the opportunity to contribute to a pooled fund that will be disbursed by our expert grantmakers. Our grantmakers can track the evolving risk and funding landscapes in real time to fill strategic gaps, launch new projects and requests for proposals backed by a pre-capitalized fund, and move on time-sensitive opportunities within days. By contributing to the ECF, you can support impactful organizations without needing to investigate individual organizations’ budgets, track record, and counterfactual likelihood of funding.
Consider donating to the ECF today.
What will the ECF do with marginal funding?
Longview will allocate marginal ECF funding to organizations we investigate in 2026. To understand our worldview and the sort of grants we typically make, you can read our 2025 ECF Annual Report. In general, our investigations focus on the projects’ impact on reducing global catastrophic risks. For ECF grants, we consider two additional [...]
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Outline:
(00:12) What is the ECF?
(01:12) What will the ECF do with marginal funding?
(02:51) Longview in 2025
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Open Phil's Global Catastrophic Risks (GCR) team is growing quickly. This year, we expect to make well over $500M in grants across our AI and biosecurity work (that's more than a 60% increase over 2024) and we’re hoping to expand that significantly over the months and years to come.
We’re currently hiring several Chief of Staff roles for different parts of our GCR team, each of which we think could substantially boost some of our top priority projects.
Specifically, we’re hiring:
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Outline:
(01:58) Why these roles?
(04:49) What does a Chief of Staff actually do?
(06:13) Apply to OP!
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Earlier this year, we announced that we’re relaunching our one-on-one career advising program. We’re happy to share that we’ve since roughly doubled our advising capacity, and are excited to speak to even more people across cause areas and career stages. We’re also developing our adjacent programs, like our career impact workshops for groups.
What this means for you in practice:
If you have any other questions, comments, suggestions, or requests, please get in touch to let us know!
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By identifying and promoting high-impact giving opportunities, Animal Charity Evaluators (ACE) aims to help people help more animals. We believe this approach to be particularly important for effective animal advocacy (EAA) because this cause area is not only deeply underfunded, the problem is growing (yet solvable!). During Marginal Funding Week, we present our thoughts on how filling ACE's need for additional funding will empower us to help the movement reduce avoidable suffering for trillions of animals on farms and in the wild.
We need to raise at least $535,740 by March 31, 2026 to grow our meta-fundraising capacity (meaning our ability to raise money for the high-impact charities we recommend and for the highly promising projects we support through our Movement Grants program) and continue to improve the quality of our research in our next fiscal year. We do the research so that effectiveness-minded donors can conveniently and confidently maximize their impact for animals by donating to our Recommended Charity Fund and our Movement Grants. But we expect that the greatest counterfactual impact of our work comes from drawing new donors to EAA. This demands we invest in outreach and growth.
Our Track RecordEncouraging high-impact charity donations---
Outline:
(00:23) Summary
(01:41) Our Track Record
(01:44) Encouraging high-impact charity donations
(02:55) Driving funding for highly-promising projects
(03:59) Charity evaluations and recommendations
(08:57) Our Need for Funding
(09:38) Strategic goals for the coming years
(11:38) Specific use of funds for meta-fundraising
(14:10) Specific use of funds for improved evaluations and strategy
(15:13) Why ACE?
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