Friday, May 8, 2026 - Week 19

CURE SYNGAP1 STRATEGY WORKING

Our strategy has always been to derisk SYNGAP1 so that industry will invest and bring their skill and capital to bear.  We leverage donor dollars to maximize impact.  Yesterday was a great example:

EARNINGS REPORTS

CAMP4 1Q26 Results: $99M https://investors.camp4tx.com/news-releases/news-release-details/camp4-reports-first-quarter-2026-financial-results-and-corporate

We submitted our first regulatory filing for CMP-002 in Australia which positions us to initiate a global first-in-human Phase 1/2 clinical trial in the second half of 2026.

Stoke 1Q26 Results: $411M https://investor.stoketherapeutics.com/news-releases/news-release-details/stoke-therapeutics-announces-first-quarter-2026-financial 

Lead optimization is underway to identify a clinical candidate for the treatment of SYNGAP1 in 2026. SYNGAP1 is a severe and rare genetic neurodevelopmental disease.

Praxis 1Q26 Results: $1.4B https://investors.praxismedicines.com/news-releases/news-release-details/praxis-precision-medicines-provides-corporate-update-and-19 

Praxis remains on track to nominate a development candidate for each of its three early stage ASO therapeutic initiatives in the first half of 2026:  PRAX-090 is designed to address SYNGAP1 loss-of-function (LoF) mutations, a leading cause of severe intellectual disability and epilepsy in DEEs.

#CompetitionIsGoodForThePatient 

KCNT1 Big Day today - Congratulations

Post: https://www.linkedin.com/posts/graglia_kcnt1-share-7458560855744618496-X10d

Press Release: https://www.linkedin.com/posts/kcnt1-kcnt1-epilepsy-ugcPost-7458487179149787136-kH7c/

WATCH & SHARE OUR VIDEO

Watch and share the new SYNGAP1 Video, it is excellent and helps explain our cause to families and friends.  We need to turn them into supporters and donors.

cureSYNGAP1.org/SYNGAP1 -> https://youtu.be/pO3ayASBiEk

INAUGURAL SF NIGHT OF IMPACT, CA – 20 days

Join us this is our only Gala for 2026!

cureSYNGAP1.org/SF26

5TH SCRAMBLE FOR SYNGAP, SC – 148 days

Classic case of a small event becoming an institution!

cureSYNGAP1.org/Scramble26

USA: use your ICD-10, F78.A1: https://onlinelibrary.wiley.com/doi/10.1002/epi.70142

PUBMED

Pubmed 2026 is at 28. +9 vs the week. (61 last year was +9) https://pubmed.ncbi.nlm.nih.gov/?term=syngap1&filter=years.2026-2026&sort=date

https://pubmed.ncbi.nlm.nih.gov/42093631/ ADHD in patients with #DLG2 #NRXN1 #SHANK3 #SYNGAP1

SOCIAL MATTERS

4,940 LinkedIn.  https://www.linkedin.com/company/curesyngap1

1,569 YouTube.  https://www.youtube.com/@CureSYNGAP1

11.1k Twitter https://twitter.com/cureSYNGAP1

45k Insta https://www.instagram.com/curesyngap1

$CAMP closed at $4.46. https://www.google.com/finance/beta/quote/CAMP:NASDAQ

$STOK closed at $32.89. https://www.google.com/finance/beta/quote/STOK:NASDAQ

$ACAD closed at $22.40. https://www.google.com/finance/beta/quote/ACAD:NASDAQ

$PRAX closed at $330.02. https://www.google.com/finance/beta/quote/PRAX:NASDAQ

Like and subscribe to this podcast wherever you listen. https://curesyngap1.org/podcasts/syngap10

Episode 207 of #Syngap10 #SYNGAP1 #CureSYNGAP1 #Podcast #PatientAdvocacy