This episode is a discussion with Dr. James Dorling who is at the Pennington Biomedical Research Center in Baton Rouge, Louisiana.  He along with co-authors from Pennington, Tufts University, Duke University and Washington University in Saint Louise provided a review on the effects of caloric restriction on human physiological, psychological, and behavioral outcomes with a special focus on results from the CALORIE Phase 2 study, a randomized control trial to determine the effect of reducing caloric intake by 20% on various markers of aging. We will discuss these key finding and what is next for us to learn about caloric restriction.