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Järvinen-Seppo discusses how translational research is advancing understanding of early allergic disease, from maternal antibodies to global collaborations shaping the future of prevention and care.
Timestamps:
00:57 – Research scope
03:49 – Maternal antibodies
07:34 – Integrating new evidence
09:17 – International coordination
10:37 – Emerging areas
This episode examines the spectrum of food allergy, from IgE-mediated disease to food protein induced enterocolitis syndrome and eosinophilic conditions, and explores how diet, skin barrier function, and the microbiome interact in early life.
Timestamps:
00:53 – Spectrum of allergic diseases
05:00 – Nutrition and immune activation
07:22 – Atopic dermatitis
08:55 – IgE-mediated food allergy
10:28 – Future management pathways
In this episode of Onc Now, Claire Snyder explores the growing importance of patient-reported outcomes and quality of life in modern oncology care. She discusses the challenges and opportunities of integrating patient perspectives into routine practice, as well as the global effort to standardise these measures through initiatives such as the PROTEUS Consortium. The conversation also highlights the evolving needs of survivors of cancer, key priorities in survivorship care, and what the future holds for patient-centred oncology.
Timestamps:
00:00 – Introduction
01:41 – Modern oncology care
03:56 – Patient-reported outcomes (PRO) interest origin
05:10 - PRO implementation challenges
06:36 - PROTEUS Consortium mission
08:33 - Survivorship care priorities
09:45 - Childhood survivor insights
12:35 - Advice for newcomers
13:37 - Future quality of life developments
14:41 - Three wishes
Kirsi Järvinen-Seppo explores how the infant immune system develops, highlighting the role of maternal environment, breast milk composition, and early-life exposures in shaping allergy risk.
Timestamps:
00:57 – Infant immune system
02:06 – Maternal lifestyle factors
06:10 – Breast milk composition
10:13 – ESCAPE study
13:25 – Early sensitisation pathways
16:58 – Early risk stratification
In this rapid-fire episode, Kirsi Järvinen-Seppo tackles key questions on infant immune development, common misconceptions around food allergy, and the early-life factors that shape allergic disease. She also highlights emerging research on maternal influences, breast milk immunology, and prevention strategies that could transform clinical practice.
In the final deep dive, Cherry Lim looks ahead to the future of AMR surveillance. She discusses the role of microbiology labs, the value of imperfect datasets, and how integrating genomics, modelling, and cost-effectiveness could transform global health systems over the next two decades.
Timestamps
00:00 – Introduction
01:03 – Investing in diagnostics 02:36 – Routine surveillance data 03:53 – Global versus local AMR data 05:08 – Future health systems
In this second deep dive episode, Cherry Lim discusses how complex modelling approaches can translate into practical clinical insights. From counterfactual frameworks to real-world prescribing decisions, she explores how data-driven tools can support clinicians in choosing more effective antibiotic treatments.
Timestamps
00:00 – Introduction
01:03 – Understanding counterfactual frameworks
02:56 – Antibiotic choice and survival
05:08 – Clinical decision dashboards
06:24 – Assumptions in AMR modelling
In this episode of Hema Now, Marilyn Manco-Johnson explores the evolution and future of paediatric haemophilia care. From the early adoption of prophylactic treatment to today's rapidly advancing therapeutic landscape, she reflects on the milestones that have transformed outcomes for children. The conversation also dives into ongoing challenges, including joint health, variability in treatment response, and access to care, while highlighting emerging innovations such as gene therapy and non-factor therapies that could redefine long-term management.
Timestamps:
00:00 – Introduction
00:49 - Career inspiration
04:40 - Prophylaxis turning points
09:41 - Key care advances
12:12 - Current research questions
15:00 - Joint risk factors
19:10 - Emerging therapies impact
24:24 – Recognising joint pain
26:08 - Gaps in care
29:11 - Future priorities
In this first deep dive, Lim explores how routine hospital data and bacterial genomics are transforming our understanding of AMR. She explains how combining datasets and transmission models can uncover hidden pathways of resistance and highlights the challenges of working across diverse healthcare settings.
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