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In this episode of Onc Now, Jonathan Stevenson explores the evolving field of orthopaedic oncology, highlighting the clinical challenges and innovations shaping the care of patients with bone and soft-tissue sarcomas. The conversation covers key hurdles in limb-salvage surgery, the ongoing challenge of prosthetic joint infection, and promising developments in translational research. He also shares insights into multidisciplinary collaboration, the vision behind future metastatic trials, and advice for the next generation of orthopaedic surgeons.
Timestamps:
00:00 - Introduction
02:16 - Overview of orthopaedic oncology challenges
08:40 - Pressing hurdles in limb-salvage surgery
13:27 – Prosthetic joint infections
17:00 - Promising developments in research
19:10 - Vision of NIHR metastatic trial
22:12 - Multidisciplinary care approach strategies
24:39 - Advice for early-career surgeons
26:22 - Transformative changes next decade
28:12 - Three 'magic wishes' for future care
In this first deep dive, Leslie Cho explores how lipidology and hormone therapy intersect in women's cardiovascular care. Drawing on major guideline work and trial data, she explains how clinicians should approach menopausal hormone therapy, complex lipid disorders, microvascular disease, and emerging therapies through a precision lens.
Timestamps:
01:10 – Menopausal hormone therapy
03:45 – Lipid-lowering therapy
05:55 – Microvascular disease
07:55 – Testosterone therapy
In this rapid-fire episode, Leslie Cho answers essential questions on women's cardiovascular health, from overlooked risk factors and lipid values to myths about chest pain, microvascular disease, menopause, and the future of precision cardiology.
In the final deep dive, Matteo Bassetti discusses antimicrobial resistance beyond the bedside: translating evidence into policy, the importance of national surveillance, lessons from sepsis and COVID-19, and the future of antibiotic innovation and hospital preparedness.
Timestamps:
01:24 – Translating evidence into policy
02:54 – National surveillance
04:15 – Sepsis and COVID-19
06:18 – Investment shortfalls
08:41 – Antibiotic crisis
10:19 – Looking ahead
In the second deep dive, Matteo Bassetti examines antibiotic stewardship where policy meets practice. He highlights gaps between guidelines and bedside realities, practical interventions for limited-resource settings, and balancing preservation of new antibiotics with effective treatment today.
Timestamps:
01:27 – Guideline gaps
04:40 – Encouraging stewardship
06:23 – Realistic interventions
09:59 – Antibiotic shortages
11:16 – Preserving new drugs
In this episode of Hema Now, Ana Boban discusses her vision as the incoming EAHAD President for 2026–2028. From her early experiences in haemophilia care to her leadership in European clinical trials and guideline development, she reflects on the future of bleeding disorders in Europe, highlighting the importance of supporting young clinicians and researchers, advancing clinical practice, and driving innovation in haemophilia care and research.
Timestamps:
00:00 – Introduction
01:38 - Vision for EAHAD Presidency
03:50 - Building on Past Leadership
06:45 - Key Priorities: Practice, Research, Education
09:05 - EAHAD Congress Highlights
11:20 - European Haemophilia Landscape Today
14:17 - Advances Influencing Clinical Care
16:14 - Unmet Needs in Europe
17:45 - Supporting Young Clinicians, Researchers
20:00 - Long-Term Goals Beyond 2028
TBC- Three Wishes for Haemophilia
1. In this first deep dive, Bassetti discusses the changing landscape of antimicrobial resistance in hospitals and ICUs, the challenges of multidrug-resistant Gram-negative bacteria, and the vulnerability of patients who are critically ill and immunocompromised. He explores how diagnosis, empiric therapy, and therapeutic monitoring influence outcomes and resistance.
Timestamps:
01:09 – Antimicrobial resistance trends
04:06 – Tackling sepsis
06:39 – Gram-negative threat
08:15 – Vulnerable populations
10:00 – Diagnosis and empiric therapy
12:14 – Dosing and pharmacokinetics
14:32 – Antibiotic allergies
Matteo Bassetti joins the EMJ Podcast for a rapid-fire discussion on antimicrobial resistance in hospitals. From prescribing pitfalls to early versus precise antibiotic use, he shares insights on howantimicrobial resistance is impacting real-world clinical care.
Drawing on her landmark work in HIV and vaccine research, Glenda Gray shares powerful lessons for tackling AMR in this last deep dive episode. From prevention and behavioural science to protecting high-risk populations, she explains how strategies that transformed HIV outcomes can inform a more effective and equitable AMR response.
Timestamps: 00:00 – Introduction
01:02 – Lessons from HIV
02:47 – Vaccine trials
03:50 – AMR interventions
05:17 – Behavioural science
06:31 – Key takeaways
In this second deep dive, Glenda Gray examines why the global antibiotic pipeline is failing and how access gaps are fuelling resistance. She discusses GARDP's mission-driven research and development model, the neglect of paediatric antibiotics, and how shortages of first-line treatments drive reliance on last-resort drugs, worsening the antimicrobial resistance crisis.
Timestamps: 00:00 – Introduction
00:58 – Antibiotic development
03:05 – GARDP's model
04:15 – Paediatric antibiotics
04:58 – Antibiotic shortages
05:50 – Access gaps
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