EMplify by EB Medicine

In this episode, Sam Ashoo, MD, Dr. Christopher Baugh, MD, MBA, and Dr. Xin Qi, MD, discuss the October 2026 Emergency Medicine Practice article, Antithrombotic-Associated Bleeding: Management in the Emergency Department.

1:18 — Guest introductions

1:58 — Why the authors chose this topic

3:11 — Epidemiology

4:27 — Why DOACs over warfarin

5:15 — Bleeding trends

6:55 — Overlapping antithrombotic regimens

8:09 — Reversibility of agents

9:38 — Bedside priorities

11:31 — Bleeding patterns by drug class & three groups

13:50 — Antithrombotics & traumatic bleeding risk

14:26 — Pre-hospital considerations

16:09 — Indications for antithrombotic use & risk of reversing

17:54 — Gray-area decisions

19:02 — Initial resuscitation

20:08 — Blood product ratios

21:24 — PATCH trial

22:04 — TXA evidence

23:36 — GI bleed adjuncts

24:31 — Critical site bleeds

27:20 — Endoscopy timing

30:00 — Reversal agents

32:50 — Idarucizumab for dabigatran

33:54 — Antiplatelet reversal

36:15 — Warfarin reversal

38:36 — Protamine for heparin/LMWH

39:37 — Fibrinolytic reversal

40:14 — Pre-procedural antithrombotic management

42:39 — Emerging labs

43:50 — Wrap-up & closing promo

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Emergency Medicine Residents, get your free subscription by writing [email protected]

In this episode, Sam Ashoo, MD and Dr. T.R. Eckler, MD discuss the September 2026 Emergency Medicine Practice article, Emergency Department Diagnosis and Management of Acetaminophen or Salicylate Toxicity

1:13 — Welcome and topic introduction

3:50 — Key rules: check levels, call Poison Control

5:13 — Acetaminophen pathophysiology

8:16 — Salicylate pathophysiology

10:51 — Coingestions

11:11 — Differential diagnosis

12:19 — History & pre-hospital care

15:28 — Product confusion

17:08 — Toxic dose thresholds

18:26 — Physical exam & vital signs

20:16 — Acetaminophen toxicity stages (1-4)

22:35 — Salicylate exam findings

23:43 — Lab workup & testing

24:45 — Acetaminophen nomogram & levels

30:39 — Activated charcoal — when to give it

34:11 — NAC therapy — dosing & timing

37:22 — Hemodialysis for acetaminophen

38:40 — King's College Criteria

41:00 — Salicylate treatment

44:42 — Potassium management during alkalinization

47:28 — Hemodialysis for salicylate

48:05 — Intubation

50:00 — Pregnancy considerations

51:20 — Pediatric considerations

52:06 — Emerging: fomepizole as adjunct therapy

52:45 — Summary & wrap-up

Subscribers, take the CME test here.

Emergency Medicine Residents, get your free subscription by writing [email protected]

In this episode, Sam Ashoo, MD and Dr. Syeda Maria Muzammil, MD discuss the August 2026 Emergency Medicine Practice article, Emergency Department Management of Postthrombolysis Intracranial Hemorrhage.

• 0:25 – Intro & sponsor message
• 1:18 – Guest introduction: Dr. Maria Muzammil
• 2:24 – Timeframe for post-thrombolysis hemorrhage & ED/ICU boarding considerations
• 4:46 – Thrombolysis eligibility criteria & contraindications
• 5:46 – Incidence rates & symptomatic vs. asymptomatic hemorrhage
• 7:09 – Pathophysiology & risk factors for post-thrombolytic ICH
• 10:18 – Combining IV thrombolysis with endovascular thrombectomy
• 12:33 – Post-treatment monitoring protocols & neurological exam frequency
• 15:02 – Differentiating hemorrhage from other causes of neurological decline
• 18:34 – Initial ED steps
• 20:35 – Heidelberg classification of hemorrhage types
• 21:60 – Follow-up imaging
• 25:27 – Treatment of confirmed hemorrhage
• 30:10 – Platelet transfusion guidance
• 32:39 – Delayed hemorrhage & treatment timing considerations
• 34:21 – Blood pressure management goals post-hemorrhage
• 37:20 – Special populations
• 38:48 – Summary of ED management algorithm
• 40:48 – Closing remarks

Subscribers, take the CME test here.

Emergency Medicine Residents, get your free subscription by writing [email protected]

In this episode, Sam Ashoo, MD and Dr. T.R. Eckler, MD discuss the July 2026 Emergency Medicine Practice article, Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Diagnosis and Management in the Emergency Department.

• 0:17 – Intro & sponsor promo
• 1:09 – Episode introduction
• 4:03 – Definitions: SJS vs. TEN vs. "overlap" by body surface area
• 6:12 – Pathophysiology
• 9:52 – Incidence and rarity of the disease
• 10:53 – Differential diagnosis & clinical presentation clues
• 12:08 – Prehospital care & fluid resuscitation considerations
• 13:47 – ED history-taking: medications, infections, rash progression
• 14:47 – Physical exam findings
• 16:46 – Diagnostic studies
• 18:12 – Scoring systems: SCORTEN and ABCD-10
• 20:50 – Treatment goals
• 23:57 – Wound care principles
• 24:43 – Mechanical ventilation risk factors
• 26:02 – Other possible therapies
• 27:50 – Specialty consults & special populations
• 29:06 – Ophthalmologic treatment
• 31:17 – HIV patients and elevated risk
• 31:55 – Emerging therapies & AI-based diagnostic tools
• 32:57 – Five key clinical takeaways
• 34:37 – Closing remarks & sponsor sign-off

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Emergency Medicine Residents, get your free subscription by writing [email protected]

In this episode, Sam Ashoo, MD and Dr. T.R. Eckler, MD discuss the June 2026 Emergency Medicine Practice article, Diagnosis and Management of Heat Stroke and Other Heat-Related Illness in the Emergency Department

• 0:21 Intro & Promo
• 0:56 Episode Introduction
• 3:14 Spectrum of Heat-Related Illnesses
• 7:37 Differential Diagnosis
• 8:58 Pre-Hospital Management
• 11:54 Exertional Heat Stroke
• 13:50 Non-Exertional Heat Stroke
• 15:40 ED Evaluation
• 21:54 ED Treatment
• 27:15 Managing Complications
• 29:33 Special Populations
• 30:58 Disposition & J-ERATO Score
• 33:12 Risk Management Pearls
• 36:56 Wrap-Up & Promo

Subscribers, take the CME test here.

Emergency Medicine Residents, get your free subscription by writing [email protected]

In this episode, Sam Ashoo, MD and Dr. T.R. Eckler, MD discuss the May 2026 Emergency Medicine Practice article, Emergency Department Evaluation and Management of Serious and High-Risk Infections in the Febrile Returning Traveler.

• 0:16 — Podcast Introduction
• 1:08 — Episode Introduction
• 7:30 — Malaria
• 13:55 — Dengue
• 17:33 — Enteric Fever (Typhoid/Paratyphoid)
• 20:53 — Leptospirosis
• 22:43 — Clinical Presentations
• 26:33 — Diagnostic Testing
• 33:17 — Treatment
• 38:59 — Special Populations & Risk Pitfalls
• 43:05 — Closing Pearls & Outro

Subscribers, take the CME test here. 

Emergency Medicine Residents, get your free subscription by writing [email protected]

In this episode, Sam Ashoo, MD and Dr. T.R. Eckler, MD discuss the April 2026 Emergency Medicine Practice article, Wide Complex Tachycardia in the Emergency Department: An Updated Approach to Diagnosis and Management.



• Introduction – 0:11
• Article Overview – 2:02
• Top 5 Bedside Steps – 7:54
• Sodium Channel Blockade – 9:26
• Hyperkalemia – 11:53
• SVT with Aberrancy – 12:47
• WPW & Accessory Pathway – 13:34
• AFib with Accessory Pathway – 14:09
• Monomorphic VT – 19:01
• Polymorphic VT / Torsades – 20:08
• Bidirectional VT – 21:29
• Pacemaker-Mediated Tachycardia – 22:30
• Pre-Hospital Considerations – 24:52
• Stable vs. Unstable Assessment – 27:58
• Diagnostic Studies – 29:42
• Treatment – 38:00
• Risk Management Pitfalls – 44:49
• Wrap-Up – 49:44

Subscribers, take the CME test here.

Emergency Medicine Residents, get your free subscription by writing [email protected]

• Introduction & Welcome — 0:17
• Jack's Background in Healthcare AI — 0:58
• Brief History of AI — 3:57
• The "Perfect Storm" That Created Modern AI — 5:48
• From General to Specialized: Fine-Tuning AI for Medicine — 7:04
• LLM Confidence & the Sycophancy Problem — 13:01
• The Benchmark Problem — 14:25
• Building Your Own Personal AI Benchmark — 17:44
• Can You "Turn Off" AI Sycophancy? — 20:00
• RAG Systems & How Specialty AI Tools Work — 22:09
• Choosing the Right AI Tool for Clinical Use — 26:18
• Why 95% of AI Pilots Fail in Deployment— 28:10
• How to Ask AI Questions Well (Prompt Quality) — 31:25
• Knowledge Base Currency & Sam's Drug Withdrawal Test — 35:06
• Closing & Contact Info — 37:12

In this episode, Sam Ashoo, MD and Dr. Dana Klavansky, MD discuss the March 2026 Emergency Medicine Practice article, Emergency Department Evaluation and Management of Severe Traumatic Brain Injury

• Introduction & Welcome (0:15)
• Guest Introduction (0:55)
• Epidemiology of Severe TBI (2:37)
• Pathophysiology: Primary vs. Secondary TBI (4:24)
• Types of Hemorrhage and Hematomas (5:25)
• Classification (7:31)
• Mild vs. Moderate vs. Severe TBI
• Impact Loading vs. Inertial Loading
• Differential Diagnosis (9:22)
• Prehospital Care (9:42)
• Emergency Department History (13:33)
• Diagnostics (15:13)
• CT Scan and the A-B-B-B-C Approach
• Repeat CT Timing
• Bedside Ultrasound for Optic Nerve Sheath Diameter
• Pupillometry
• Biomarkers
• Treatment (24:52)
• Airway Management
• Ventilation and CO2 Targets
• Hyperosmolar Therapy: Hypertonic Saline and Mannitol
• Cerebral Perfusion Pressure
• Blood Pressure Goals
• Temperature Management
• Coagulopathy Management
• Seizure Prophylaxis and EEG Monitoring
• Tiered ICP Management (35:29)
• Surgical Indications (38:40)
• Prognosis (40:33)
• Special Topics (41:30)
• Sports Injuries and CTE
• Tranexamic Acid (CRASH-3 Trial)
• Wrap-Up (43:46)

Subscribers, take the CME test here.

Emergency Medicine Residents, get your free subscription by writing [email protected]

In this episode, Sam Ashoo, MD and T.R. Eckler, MD discuss the February 2026 Emergency Medicine Practice article, Emergency Department Diagnosis and Management of Acute Coronary Occlusion

00:00 - Introduction & Welcome

01:21 - Episode Overview: Acute Coronary Occlusion

02:06 - Why This Topic Matters: Statistics & New Guidelines

03:35 - Nomenclature: ACO vs STEMI/NSTEMI

06:15 - Differential Diagnosis for STEMI

07:41 - Pre-Hospital Care & EMS Role

11:37 - Patient History & Presenting Symptoms

12:28 - Physical Examination Findings

14:54 - EKG: The Most Important Test

17:00 - STEMI Definition & Criteria

20:32 - STEMI Equivalents: Scarbosa Criteria

22:40 - Smith Modified Scarbosa Criteria

24:10 - Hyperacute T Waves

25:30 - Posterior STEMI

28:40 - De Winter Sign

29:38 - Non-STEMI EKG Findings

31:30 - AVR ST Elevation

32:47 - Wellens Syndrome

33:54 - Reciprocal ST Segment Changes

36:15 - Inferior MI Patterns

37:54 - Laboratory Testing

39:51 - Imaging: Chest X-Ray & Echocardiography

42:25 - Supplemental Oxygen: What the Evidence Shows

44:50 - Analgesia & Pain Management

46:35 - Pharmacotherapy: Aspirin & Antiplatelet Agents

49:18 - Reperfusion Therapies & Thrombolytics

53:05 - Cardiac Arrest in STEMI Patients

53:55 - Closing Remarks & CME Information