EMplify by EB Medicine

In this episode, Sam Ashoo, MD and Dr. T.R. Eckler, MD discuss the September 2026 Emergency Medicine Practice article, Emergency Department Diagnosis and Management of Acetaminophen or Salicylate Toxicity

1:13 — Welcome and topic introduction

3:50 — Key rules: check levels, call Poison Control

5:13 — Acetaminophen pathophysiology

8:16 — Salicylate pathophysiology

10:51 — Coingestions

11:11 — Differential diagnosis

12:19 — History & pre-hospital care

15:28 — Product confusion

17:08 — Toxic dose thresholds

18:26 — Physical exam & vital signs

20:16 — Acetaminophen toxicity stages (1-4)

22:35 — Salicylate exam findings

23:43 — Lab workup & testing

24:45 — Acetaminophen nomogram & levels

30:39 — Activated charcoal — when to give it

34:11 — NAC therapy — dosing & timing

37:22 — Hemodialysis for acetaminophen

38:40 — King's College Criteria

41:00 — Salicylate treatment

44:42 — Potassium management during alkalinization

47:28 — Hemodialysis for salicylate

48:05 — Intubation

50:00 — Pregnancy considerations

51:20 — Pediatric considerations

52:06 — Emerging: fomepizole as adjunct therapy

52:45 — Summary & wrap-up

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Emergency Medicine Residents, get your free subscription by writing [email protected]

In this episode, Sam Ashoo, MD and Dr. Syeda Maria Muzammil, MD discuss the August 2026 Emergency Medicine Practice article, Emergency Department Management of Postthrombolysis Intracranial Hemorrhage.

• 0:25 – Intro & sponsor message
• 1:18 – Guest introduction: Dr. Maria Muzammil
• 2:24 – Timeframe for post-thrombolysis hemorrhage & ED/ICU boarding considerations
• 4:46 – Thrombolysis eligibility criteria & contraindications
• 5:46 – Incidence rates & symptomatic vs. asymptomatic hemorrhage
• 7:09 – Pathophysiology & risk factors for post-thrombolytic ICH
• 10:18 – Combining IV thrombolysis with endovascular thrombectomy
• 12:33 – Post-treatment monitoring protocols & neurological exam frequency
• 15:02 – Differentiating hemorrhage from other causes of neurological decline
• 18:34 – Initial ED steps
• 20:35 – Heidelberg classification of hemorrhage types
• 21:60 – Follow-up imaging
• 25:27 – Treatment of confirmed hemorrhage
• 30:10 – Platelet transfusion guidance
• 32:39 – Delayed hemorrhage & treatment timing considerations
• 34:21 – Blood pressure management goals post-hemorrhage
• 37:20 – Special populations
• 38:48 – Summary of ED management algorithm
• 40:48 – Closing remarks

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Emergency Medicine Residents, get your free subscription by writing [email protected]

In this episode, Sam Ashoo, MD and Dr. T.R. Eckler, MD discuss the July 2026 Emergency Medicine Practice article, Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Diagnosis and Management in the Emergency Department.

• 0:17 – Intro & sponsor promo
• 1:09 – Episode introduction
• 4:03 – Definitions: SJS vs. TEN vs. "overlap" by body surface area
• 6:12 – Pathophysiology
• 9:52 – Incidence and rarity of the disease
• 10:53 – Differential diagnosis & clinical presentation clues
• 12:08 – Prehospital care & fluid resuscitation considerations
• 13:47 – ED history-taking: medications, infections, rash progression
• 14:47 – Physical exam findings
• 16:46 – Diagnostic studies
• 18:12 – Scoring systems: SCORTEN and ABCD-10
• 20:50 – Treatment goals
• 23:57 – Wound care principles
• 24:43 – Mechanical ventilation risk factors
• 26:02 – Other possible therapies
• 27:50 – Specialty consults & special populations
• 29:06 – Ophthalmologic treatment
• 31:17 – HIV patients and elevated risk
• 31:55 – Emerging therapies & AI-based diagnostic tools
• 32:57 – Five key clinical takeaways
• 34:37 – Closing remarks & sponsor sign-off

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Emergency Medicine Residents, get your free subscription by writing [email protected]

In this episode, Sam Ashoo, MD and Dr. T.R. Eckler, MD discuss the June 2026 Emergency Medicine Practice article, Diagnosis and Management of Heat Stroke and Other Heat-Related Illness in the Emergency Department

• 0:21 Intro & Promo
• 0:56 Episode Introduction
• 3:14 Spectrum of Heat-Related Illnesses
• 7:37 Differential Diagnosis
• 8:58 Pre-Hospital Management
• 11:54 Exertional Heat Stroke
• 13:50 Non-Exertional Heat Stroke
• 15:40 ED Evaluation
• 21:54 ED Treatment
• 27:15 Managing Complications
• 29:33 Special Populations
• 30:58 Disposition & J-ERATO Score
• 33:12 Risk Management Pearls
• 36:56 Wrap-Up & Promo

Subscribers, take the CME test here.

Emergency Medicine Residents, get your free subscription by writing [email protected]

In this episode, Sam Ashoo, MD and Dr. T.R. Eckler, MD discuss the May 2026 Emergency Medicine Practice article, Emergency Department Evaluation and Management of Serious and High-Risk Infections in the Febrile Returning Traveler.

• 0:16 — Podcast Introduction
• 1:08 — Episode Introduction
• 7:30 — Malaria
• 13:55 — Dengue
• 17:33 — Enteric Fever (Typhoid/Paratyphoid)
• 20:53 — Leptospirosis
• 22:43 — Clinical Presentations
• 26:33 — Diagnostic Testing
• 33:17 — Treatment
• 38:59 — Special Populations & Risk Pitfalls
• 43:05 — Closing Pearls & Outro

Subscribers, take the CME test here. 

Emergency Medicine Residents, get your free subscription by writing [email protected]

In this episode, Sam Ashoo, MD and Dr. T.R. Eckler, MD discuss the April 2026 Emergency Medicine Practice article, Wide Complex Tachycardia in the Emergency Department: An Updated Approach to Diagnosis and Management.



• Introduction – 0:11
• Article Overview – 2:02
• Top 5 Bedside Steps – 7:54
• Sodium Channel Blockade – 9:26
• Hyperkalemia – 11:53
• SVT with Aberrancy – 12:47
• WPW & Accessory Pathway – 13:34
• AFib with Accessory Pathway – 14:09
• Monomorphic VT – 19:01
• Polymorphic VT / Torsades – 20:08
• Bidirectional VT – 21:29
• Pacemaker-Mediated Tachycardia – 22:30
• Pre-Hospital Considerations – 24:52
• Stable vs. Unstable Assessment – 27:58
• Diagnostic Studies – 29:42
• Treatment – 38:00
• Risk Management Pitfalls – 44:49
• Wrap-Up – 49:44

Subscribers, take the CME test here.

Emergency Medicine Residents, get your free subscription by writing [email protected]

• Introduction & Welcome — 0:17
• Jack's Background in Healthcare AI — 0:58
• Brief History of AI — 3:57
• The "Perfect Storm" That Created Modern AI — 5:48
• From General to Specialized: Fine-Tuning AI for Medicine — 7:04
• LLM Confidence & the Sycophancy Problem — 13:01
• The Benchmark Problem — 14:25
• Building Your Own Personal AI Benchmark — 17:44
• Can You "Turn Off" AI Sycophancy? — 20:00
• RAG Systems & How Specialty AI Tools Work — 22:09
• Choosing the Right AI Tool for Clinical Use — 26:18
• Why 95% of AI Pilots Fail in Deployment— 28:10
• How to Ask AI Questions Well (Prompt Quality) — 31:25
• Knowledge Base Currency & Sam's Drug Withdrawal Test — 35:06
• Closing & Contact Info — 37:12

In this episode, Sam Ashoo, MD and Dr. Dana Klavansky, MD discuss the March 2026 Emergency Medicine Practice article, Emergency Department Evaluation and Management of Severe Traumatic Brain Injury

• Introduction & Welcome (0:15)
• Guest Introduction (0:55)
• Epidemiology of Severe TBI (2:37)
• Pathophysiology: Primary vs. Secondary TBI (4:24)
• Types of Hemorrhage and Hematomas (5:25)
• Classification (7:31)
• Mild vs. Moderate vs. Severe TBI
• Impact Loading vs. Inertial Loading
• Differential Diagnosis (9:22)
• Prehospital Care (9:42)
• Emergency Department History (13:33)
• Diagnostics (15:13)
• CT Scan and the A-B-B-B-C Approach
• Repeat CT Timing
• Bedside Ultrasound for Optic Nerve Sheath Diameter
• Pupillometry
• Biomarkers
• Treatment (24:52)
• Airway Management
• Ventilation and CO2 Targets
• Hyperosmolar Therapy: Hypertonic Saline and Mannitol
• Cerebral Perfusion Pressure
• Blood Pressure Goals
• Temperature Management
• Coagulopathy Management
• Seizure Prophylaxis and EEG Monitoring
• Tiered ICP Management (35:29)
• Surgical Indications (38:40)
• Prognosis (40:33)
• Special Topics (41:30)
• Sports Injuries and CTE
• Tranexamic Acid (CRASH-3 Trial)
• Wrap-Up (43:46)

Subscribers, take the CME test here.

Emergency Medicine Residents, get your free subscription by writing [email protected]

In this episode, Sam Ashoo, MD and T.R. Eckler, MD discuss the February 2026 Emergency Medicine Practice article, Emergency Department Diagnosis and Management of Acute Coronary Occlusion

00:00 - Introduction & Welcome

01:21 - Episode Overview: Acute Coronary Occlusion

02:06 - Why This Topic Matters: Statistics & New Guidelines

03:35 - Nomenclature: ACO vs STEMI/NSTEMI

06:15 - Differential Diagnosis for STEMI

07:41 - Pre-Hospital Care & EMS Role

11:37 - Patient History & Presenting Symptoms

12:28 - Physical Examination Findings

14:54 - EKG: The Most Important Test

17:00 - STEMI Definition & Criteria

20:32 - STEMI Equivalents: Scarbosa Criteria

22:40 - Smith Modified Scarbosa Criteria

24:10 - Hyperacute T Waves

25:30 - Posterior STEMI

28:40 - De Winter Sign

29:38 - Non-STEMI EKG Findings

31:30 - AVR ST Elevation

32:47 - Wellens Syndrome

33:54 - Reciprocal ST Segment Changes

36:15 - Inferior MI Patterns

37:54 - Laboratory Testing

39:51 - Imaging: Chest X-Ray & Echocardiography

42:25 - Supplemental Oxygen: What the Evidence Shows

44:50 - Analgesia & Pain Management

46:35 - Pharmacotherapy: Aspirin & Antiplatelet Agents

49:18 - Reperfusion Therapies & Thrombolytics

53:05 - Cardiac Arrest in STEMI Patients

53:55 - Closing Remarks & CME Information

• 0:15 Introduction
• 0:51 Guest Introduction
• 1:20 Jeff's Background
• 2:00 Current Work
• 3:37 How He Got Started
• 6:57 Pre-Litigation vs. Expert Witness
• 8:01 Four Components of Malpractice Cases
• 13:55 Case Review Statistics
• 17:11 When Cases Get Filed
• 18:58 Common Patterns in Cases
• 19:55 Documentation Best Practices
• 22:06 Shift Handoff Problems
• 25:56 Bounce Backs
• 27:25 Medical Record Volume
• 30:00 Audit Trails
• 32:53 Communication with Consultants
• 41:35 Conflicting Documentation
• 43:46 Getting Started in This Work
• 47:37 Closing