Empowered Patient Podcast

Dr. Tram Tran, the Chief Medical Officer at Glympse Bio, is taking the knowledge about the mechanistic roles protease play in many diseases to develop an injectable biosensor to measure protease activity rather than just a one-time measurement of the amount of protein in the blood. The platform uses machine learning to analyze different protease levels and the protease activity over time to come up with a classifier and differentiate between disease activity and not disease activity.

Tram explains, "So, a couple of years ago, though, I think recognizing that having an injectable platform and then having the patient urinate and check the urine for the level of protease activity might be a little bit more complicated than what would be ideal in the clinic for the patient. We actually were able to switch over to a blood-based test, where we are able to measure the patient's disease activity via protease activity via a simple blood test. And so, I think that was really a remarkable change over the past couple of years."

"We've been working on a couple of different diseases and better understanding how to measure and understand diseases and protease activity through a simple blood test now. So, I think that's really important. This ex vivo platform development was a key change. We presented data last year on NASH, which is a very common disease, non-alcoholic steatohepatitis. And this year, we're talking more about liver cancer or hepatocellular carcinoma."

@GlympseBio #Diagnostic #Biosensor #LiverDisease #HCC #HepatocellularCarcinoma #ProteinActivity #Protease

GlympseBio.com

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Dr. Tram Tran, the Chief Medical Officer at Glympse Bio, is taking the knowledge about the mechanistic roles protease play in many diseases to develop an injectable biosensor to measure protease activity rather than just a one-time measurement of the amount of protein in the blood. The platform uses machine learning to analyze different protease levels and the protease activity over time to come up with a classifier and differentiate between disease activity and not disease activity.

Tram explains, "So, a couple of years ago, though, I think recognizing that having an injectable platform and then having the patient urinate and check the urine for the level of protease activity might be a little bit more complicated than what would be ideal in the clinic for the patient. We actually were able to switch over to a blood-based test, where we are able to measure the patient's disease activity via protease activity via a simple blood test. And so, I think that was really a remarkable change over the past couple of years."

"We've been working on a couple of different diseases and better understanding how to measure and understand diseases and protease activity through a simple blood test now. So, I think that's really important. This ex vivo platform development was a key change. We presented data last year on NASH, which is a very common disease, non-alcoholic steatohepatitis. And this year, we're talking more about liver cancer or hepatocellular carcinoma."

@GlympseBio #Diagnostic #Biosensor #LiverDisease #HCC #HepatocellularCarcinoma #ProteinActivity #Protease

GlympseBio.com

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David Vivero is the Co-Founder and Chief Executive Officer at Amino Health. He brings his experience from Zillow to make Amino a convenient site where employer-based healthcare plan members can find information about their healthcare options, make appointments, and access understandable cost estimations. The Transparency in Coverage Rule says that beginning January 1, 2023, every health insurer in the U.S. has to ensure that their members have access to the price of at least 500 services inside their health plan. That will become all services by January 1, 2024.

David explains, "Our clients are the sponsors of these health plans, these employers, the labor unions, and the health plans themselves. And the reason they partner with Amino is that we're provably able to support their members and help them make the right choice at three times the rate than if they didn't have Amino. This is part of the reason that there is this push for greater transparency so that people make better decisions. That's what we do. The savings we create for a member and the reduction in infections and readmissions for a member are very good for their employers, labor unions, states, municipalities, and health plans."

"One of the things that makes Amino so unique is that we started as a direct-to-consumer website, akin to what we did at Zillow. And I was not a healthcare maven coming into this. I really benefited from having this tabula rasa completely open-minded about dealing with these fundamental questions of how to help someone navigate healthcare."

@AminoHealth #AminoHealth #HealthcarePriceTransparency #TransparencyinCoverage #DigitalHealth #HealthcareNavigation #Healthcare

partners.amino.com

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David Vivero is the Co-Founder and Chief Executive Officer at Amino Health. He brings his experience from Zillow to make Amino a convenient site where employer-based healthcare plan members can find information about their healthcare options, make appointments, and access understandable cost estimations. The Transparency in Coverage Rule says that beginning January 1, 2023, every health insurer in the U.S. has to ensure that their members have access to the price of at least 500 services inside their health plan. That will become all services by January 1, 2024.

David explains, "Our clients are the sponsors of these health plans, these employers, the labor unions, and the health plans themselves. And the reason they partner with Amino is that we're provably able to support their members and help them make the right choice at three times the rate than if they didn't have Amino. This is part of the reason that there is this push for greater transparency so that people make better decisions. That's what we do. The savings we create for a member and the reduction in infections and readmissions for a member are very good for their employers, labor unions, states, municipalities, and health plans."

"One of the things that makes Amino so unique is that we started as a direct-to-consumer website, akin to what we did at Zillow. And I was not a healthcare maven coming into this. I really benefited from having this tabula rasa completely open-minded about dealing with these fundamental questions of how to help someone navigate healthcare."

@AminoHealth #AminoHealth #HealthcarePriceTransparency #TransparencyinCoverage #DigitalHealth #HealthcareNavigation #Healthcare

partners.amino.com

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Dr. Shrujal Baxi is a medical oncologist and the Chief Medical Officer at Iterative Health pioneer in precision medicine technologies for gastroenterology. The Iterative SKOUT polyp detection tool provides algorithmic assistance to physicians during a colonoscopy to improve the ability to detect and remove polyps. With colon cancer getting diagnosed at a younger age, it is increasingly important to detect polyps as early as possible.

Shrujal explains, "I think there's a lot of science in the space for detection of precancerous tumors throughout the body. In colon cancer currently, it's still very anatomic, which is we look for polyps, we look for abnormalities, dysplasia, we look for things that we can see on the end of the camera that's a colonoscopy. We flag them, and we try to remove them. Now, many of those lesions may never have gone on to become cancer. Part of this is our learning, over time, that there are certain polyps or certain lesions that are more likely to become cancerous, and can we target our interventions and only resect those."

"What we found is that in studies, and these are out there, when physicians do colonoscopies in the morning versus when they're done in the afternoon, there's more polyp detection in the morning than in the afternoon. And we can postulate why that might be, but it suggests that pattern recognition requires a level of sort concentration that is still a human-dependent process."

"By having AI in the background running alongside the physician's interpretation, if the physician found every one of those polyps on their own, that's great. If the physician happens to have tired eyes by the end of the day, the polyp detection tool is there to make sure that doesn't get missed. It's not meant to replace the physician. It's meant to be there to sort of be an extra set of flags, so to speak."

@Iterative_Hlth #ArtificialIntelligence #AI #Gastroenterology #Colonoscopy #ColonCancer #PatientCentricity #PrecisionMedicine

iterative.health

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Dr. Shrujal Baxi is a medical oncologist and the Chief Medical Officer at Iterative Health pioneer in precision medicine technologies for gastroenterology. The Iterative SKOUT polyp detection tool provides algorithmic assistance to physicians during a colonoscopy to improve the ability to detect and remove polyps. With colon cancer getting diagnosed at a younger age, it is increasingly important to detect polyps as early as possible.

Shrujal explains, "I think there's a lot of science in the space for detection of precancerous tumors throughout the body. In colon cancer currently, it's still very anatomic, which is we look for polyps, we look for abnormalities, dysplasia, we look for things that we can see on the end of the camera that's a colonoscopy. We flag them, and we try to remove them. Now, many of those lesions may never have gone on to become cancer. Part of this is our learning, over time, that there are certain polyps or certain lesions that are more likely to become cancerous, and can we target our interventions and only resect those."

"What we found is that in studies, and these are out there, when physicians do colonoscopies in the morning versus when they're done in the afternoon, there's more polyp detection in the morning than in the afternoon. And we can postulate why that might be, but it suggests that pattern recognition requires a level of sort concentration that is still a human-dependent process."

"By having AI in the background running alongside the physician's interpretation, if the physician found every one of those polyps on their own, that's great. If the physician happens to have tired eyes by the end of the day, the polyp detection tool is there to make sure that doesn't get missed. It's not meant to replace the physician. It's meant to be there to sort of be an extra set of flags, so to speak."

@Iterative_Hlth #ArtificialIntelligence #AI #Gastroenterology #Colonoscopy #ColonCancer #PatientCentricity #PrecisionMedicine

iterative.health

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Teodora Pavkovic is a youth psychologist and Director of Community Engagement at Linewize, whose mission is to protect every child's digital journey and to keep students safe at school, at home, and everywhere in between as they engage with the online world. The pandemic changed how students learn and socialize. The increased use of online devices, social media, and suspect websites impacted the mental health and well-being of students, and changed the responsibilities of teachers and parents to ensure safe digital behavior.

Teodora explains, "On the one hand, we are a technology company. We provide tech-based solutions in the form of filtering, classroom management, of safety monitoring. And then, more recently, a well-being assessment tool as well. And then the second piece, which is particularly relevant for me and for my work, is that community support and education. So really making sure that the staff and the parents, and the students themselves are educated around all the topics within the online safety and digital wellness realm."

"I don't think that we can talk about the youth mental health crisis and children's well-being without also really talking about that online digital component. The two are just inextricably linked at this point."

@Linewize #Linewize #MentalHealth #StudentSafety #DigitalWellness #OnlineSafety #Cybersecurity #Students

Linewize.com

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Teodora Pavkovic is a youth psychologist and Director of Community Engagement at Linewize, whose mission is to protect every child's digital journey and to keep students safe at school, at home, and everywhere in between as they engage with the online world. The pandemic changed how students learn and socialize. The increased use of online devices, social media, and suspect websites impacted the mental health and well-being of students, and changed the responsibilities of teachers and parents to ensure safe digital behavior.

Teodora explains, "On the one hand, we are a technology company. We provide tech-based solutions in the form of filtering, classroom management, of safety monitoring. And then, more recently, a well-being assessment tool as well. And then the second piece, which is particularly relevant for me and for my work, is that community support and education. So really making sure that the staff and the parents, and the students themselves are educated around all the topics within the online safety and digital wellness realm."

"I don't think that we can talk about the youth mental health crisis and children's well-being without also really talking about that online digital component. The two are just inextricably linked at this point."

@Linewize #Linewize #MentalHealth #StudentSafety #DigitalWellness #OnlineSafety #Cybersecurity #Students

Linewize.com

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Lisbeth Votruba, Chief Clinical Officer at AvaSure, reflects on the challenges for nurses and hospitals in these times of nursing shortages, burnout, and expedited retirements. The AvaSure solutions provide virtual nursing, safety monitoring, and expert virtual nursing to monitor critically ill and high-acuity patients. Experienced nurses and those trained as virtual nurses embrace this solution as a way to care for patients while supporting the efficient use of hospital resources for bedside care.

Lisbeth explains, "The first model that I'll talk about is the Telesitter® solution, which supports nurses indirectly. This involves using mobile devices or sometimes fixed cameras with really amazing audio in patient rooms. We are using that to keep patients safe, prevent falls, prevent elopement. This also was used to protect nurses from COVID because patients were ripping off their oxygen masks because they were confused and reminding them to put their masks back on again."

"Prior to this revolution in virtual patient monitoring in the hospital setting, the only thing that hospitals could think to do was assign one-to-one what they called "sitters" to confused or at-risk patients. So 5% of the hospital census would have a staff member, not a nurse, a nursing assistant sitting 24/7, watching them and trying to keep them safe physically. The Telesitter® solution allows one remote, trained staff member to monitor 12 to 16 patients, interacting with them, talking to them, and sometimes needing to use alarms to keep them safe. That frees up that bedside staff to be back out helping the rest of the care unit."

@AvaSure #VirtualNurse #VirtualCare #NurseLeaders #RegisteredNurse #AcuteCare #Nurses #Telesitter #Hospitals #DigitalHealth

AvaSure.com

Listen to the podcast here

Lisbeth Votruba, Chief Clinical Officer at AvaSure, reflects on the challenges for nurses and hospitals in these times of nursing shortages, burnout, and expedited retirements. The AvaSure solutions provide virtual nursing, safety monitoring, and expert virtual nursing to monitor critically ill and high-acuity patients. Experienced nurses and those trained as virtual nurses embrace this solution as a way to care for patients while supporting the efficient use of hospital resources for bedside care.

Lisbeth explains, "The first model that I'll talk about is the Telesitter® solution, which supports nurses indirectly. This involves using mobile devices or sometimes fixed cameras with really amazing audio in patient rooms. We are using that to keep patients safe, prevent falls, prevent elopement. This also was used to protect nurses from COVID because patients were ripping off their oxygen masks because they were confused and reminding them to put their masks back on again."

"Prior to this revolution in virtual patient monitoring in the hospital setting, the only thing that hospitals could think to do was assign one-to-one what they called "sitters" to confused or at-risk patients. So 5% of the hospital census would have a staff member, not a nurse, a nursing assistant sitting 24/7, watching them and trying to keep them safe physically. The Telesitter® solution allows one remote, trained staff member to monitor 12 to 16 patients, interacting with them, talking to them, and sometimes needing to use alarms to keep them safe. That frees up that bedside staff to be back out helping the rest of the care unit."

@AvaSure #VirtualNurse #VirtualCare #NurseLeaders #RegisteredNurse #AcuteCare #Nurses #Telesitter #Hospitals #DigitalHealth

AvaSure.com

Download the transcript here