Empowered Patient Podcast

Dr. Peter Traber is the Chief Medical officer at Selecta Biosciences, which is enabling and increasing the effectiveness of gene therapy by inhibiting the body's immune response. Their drug platform ImmTOR is a nano-encapsulated immunomodulatory drug that causes the immune system to be tolerant of antigens and inhibits the immune response. This approach may overcome an important hurdle in gene therapy and biologic therapy by allowing repeated dosing.

Peter explains, "Our immune response is very robust, and it's hard to get around it. So in order to make these therapies, either proteins or gene therapy, more effective and safer, we are tolerizing the individual to those therapies with this platform."

"So I'll give you an example from our phase three program in chronic refractory gout. We're using an enzyme to treat refractory gout, which decreases the uric acid, but it's a yeast-derived enzyme. It's an enzyme that humans don't have, and therefore it's highly immunogenic. If you give it to a human, it's only effective with one dose. In fact, by 30 days, it's not effective anymore. In contrast, when we give it with ImmTOR, we're able to give the drug monthly for 12 months. So the ImmTOR reduces the immune effect of the drug but allows it to be active and be used over the course of an entire year."

"We are collaborating with some groups on transplantation approaches. And certainly, inducing immune tolerance in that situation could be very important. And, of course, beyond that, we're also working in autoimmune diseases where the body turns against itself—so-called breaking of self-tolerance. Our program is also working on reestablishing self-tolerance in autoimmune diseases. There's a very long list of autoimmune diseases in the liver and joints and elsewhere that could be very important in this regard."

@SelectaBio #MMA #GeneTherapy #ImmuneTolerance #ImmuneSystem #AutoimmuneDiseases #Transplanation

selectabio.com

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Dr. Peter Traber is the Chief Medical officer at Selecta Biosciences, which is enabling and increasing the effectiveness of gene therapy by inhibiting the body's immune response. Their drug platform ImmTOR is a nano-encapsulated immunomodulatory drug that causes the immune system to be tolerant of antigens and inhibits the immune response. This approach may overcome an important hurdle in gene therapy and biologic therapy by allowing repeated dosing.

Peter explains, "Our immune response is very robust, and it's hard to get around it. So in order to make these therapies, either proteins or gene therapy, more effective and safer, we are tolerizing the individual to those therapies with this platform."

"So I'll give you an example from our phase three program in chronic refractory gout. We're using an enzyme to treat refractory gout, which decreases the uric acid, but it's a yeast-derived enzyme. It's an enzyme that humans don't have, and therefore it's highly immunogenic. If you give it to a human, it's only effective with one dose. In fact, by 30 days, it's not effective anymore. In contrast, when we give it with ImmTOR, we're able to give the drug monthly for 12 months. So the ImmTOR reduces the immune effect of the drug but allows it to be active and be used over the course of an entire year."

"We are collaborating with some groups on transplantation approaches. And certainly, inducing immune tolerance in that situation could be very important. And, of course, beyond that, we're also working in autoimmune diseases where the body turns against itself—so-called breaking of self-tolerance. Our program is also working on reestablishing self-tolerance in autoimmune diseases. There's a very long list of autoimmune diseases in the liver and joints and elsewhere that could be very important in this regard."

@SelectaBio #MMA #GeneTherapy #ImmuneTolerance #ImmuneSystem #AutoimmuneDiseases #Transplanation

selectabio.com

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Dr. Ryan Lee, Chairman of the Department of Radiology at the Einstein Healthcare Network, now part of Jefferson health, and Dr. Peter Seidensticker, the VP of Medical Affairs and Clinical Development at Bayer Radiology join me to talk about how Bayer's Calantic Digital Solutions is empowering radiologists. Applying AI to the workflow allows the radiologist to improve efficiency, reduce fatigue, and focus on the most important suspicious markers.

Ryan explains, "You specifically asked about the role of the radiologist. I think traditionally, people think of a radiologist as somebody who looks at images and then generates a report. But these days, the American College of Radiology – ACR-- has something called imaging 3.0. What that really means is that we, as radiologists are much more than just a report. We're involved from the beginning of ordering of the study, all the way to the communication of the results. Not just the actual interpretation of the image themselves. So I think there is a much more holistic role for radiologists than maybe the general public really knows."

Peter elaborates, "The Bayer angle is more to extract the important findings out of an image and make sure that the radiologist sees those in a pronounced way or in a marked way, making it easier for him to find them in an image. So it goes in a similar direction, but I think the key focus here is to mark findings that are tough to find in this jungle of workload and images that radiologists see every day."

#Radiology #Radiologist #AI #BayerRadiology #BayerCalantic #MedicalImaging #MedTech #WorkflowPrioritization

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Dr. Ryan Lee, Chairman of the Department of Radiology at the Einstein Healthcare Network, now part of Jefferson health, and Dr. Peter Seidensticker, the VP of Medical Affairs and Clinical Development at Bayer Radiology join me to talk about how Bayer's Calantic Digital Solutions is empowering radiologists. Applying AI to the workflow allows the radiologist to improve efficiency, reduce fatigue, and focus on the most important suspicious markers.

Ryan explains, "You specifically asked about the role of the radiologist. I think traditionally, people think of a radiologist as somebody who looks at images and then generates a report. But these days, the American College of Radiology – ACR-- has something called imaging 3.0. What that really means is that we, as radiologists are much more than just a report. We're involved from the beginning of ordering of the study, all the way to the communication of the results. Not just the actual interpretation of the image themselves. So I think there is a much more holistic role for radiologists than maybe the general public really knows."

Peter elaborates, "The Bayer angle is more to extract the important findings out of an image and make sure that the radiologist sees those in a pronounced way or in a marked way, making it easier for him to find them in an image. So it goes in a similar direction, but I think the key focus here is to mark findings that are tough to find in this jungle of workload and images that radiologists see every day."

#Radiology #Radiologist #AI #BayerRadiology #BayerCalantic #MedicalImaging #MedTech #WorkflowPrioritization

calantic.com

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Len Liptak is the Co-Founder and CEO of ProSomnus Sleep Technologies, which is providing new options for patients suffering from the chronic disease obstructive sleep apnea. This condition means that the airways are blocked while people are sleeping. The most common treatment is a CPAP device that pushes air through the blockage and down the throat to ensure the sleeper has access to oxygen. ProSomnus has designed a personalized noninvasive oral device that holds the jaw forward to create a precision jaw position and stabilization to aid in better breathing and improved sleep quality.

Len explains, "It's serious but funny, but one of the most common ways it's diagnosed is what we call the elbow test. This is where someone's bed partner notices that their bed partner is having this pause in breathing at night, and they literally elbow the bed partner and say, "Hey, wake up. You're not breathing." At first, it can be cute, but then it becomes serious."

"Oral devices for treating such sleep apnea have been on the market for a while. But the challenge is that those traditional oral appliances arbitrarily posture the jaw forward. They're not quite precision in their nature. The precision is really important because the function of an oral device is to protrude the jaw in a position that opens the airway and then stabilize the jaw in that position throughout the night."

"It's our precision technology that allows us to do that because the airway is only 10 millimeters in diameter. So if the jaw is postured too far forward, it could be counterproductive. If the jaw is not postured far enough forward, it can be counterproductive and not generate efficacy. So it's really important to precisely position the jaw based on the treatment plan and the prescription that the provider draws up for the patient so that we get maximum efficacy."

#ProSomnus #SleepApnea #ObstructiveSleepApnea #OSA #CPAP #DentalSleepMedicine #JawRepositioning #SleepMedicine

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Len Liptak is the Co-Founder and CEO of ProSomnus Sleep Technologies, which is providing new options for patients suffering from the chronic disease obstructive sleep apnea. This condition means that the airways are blocked while people are sleeping. The most common treatment is a CPAP device that pushes air through the blockage and down the throat to ensure the sleeper has access to oxygen. ProSomnus has designed a personalized noninvasive oral device that holds the jaw forward to create a precision jaw position and stabilization to aid in better breathing and improved sleep quality.

Len explains, "It's serious but funny, but one of the most common ways it's diagnosed is what we call the elbow test. This is where someone's bed partner notices that their bed partner is having this pause in breathing at night, and they literally elbow the bed partner and say, "Hey, wake up. You're not breathing." At first, it can be cute, but then it becomes serious."

"Oral devices for treating such sleep apnea have been on the market for a while. But the challenge is that those traditional oral appliances arbitrarily posture the jaw forward. They're not quite precision in their nature. The precision is really important because the function of an oral device is to protrude the jaw in a position that opens the airway and then stabilize the jaw in that position throughout the night."

"It's our precision technology that allows us to do that because the airway is only 10 millimeters in diameter. So if the jaw is postured too far forward, it could be counterproductive. If the jaw is not postured far enough forward, it can be counterproductive and not generate efficacy. So it's really important to precisely position the jaw based on the treatment plan and the prescription that the provider draws up for the patient so that we get maximum efficacy."

#ProSomnus #SleepApnea #ObstructiveSleepApnea #OSA #CPAP #DentalSleepMedicine #JawRepositioning #SleepMedicine

ProSomnus.com

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Inessa Lurye is the Senior Director of Consumer Product at Hinge Health, a digital musculoskeletal clinic with accessible digital physical therapy and whole-body care. Recently, Hinge has launched a Women's Pelvic Health program to personalize treatments for pelvic floor disorder and to expand access to pelvic floor physical therapy for underserved communities.

Inessa explains, "We span that entire continuum, and we offer individuals access to a personalized care team, which is in-house physical therapists and Board-certified coaches, and a digital product that includes exercise therapy and education to help free people from pain."

"We have personalized the experience to women and those with vaginal anatomy. One in four women has a pelvic floor disorder, and pelvic health is musculoskeletal health, but for so long, we haven't treated it as such. And so what we've done is, knowing that our clinic is a digital clinic that serves the whole person, we have personalized the experience for pelvic floor disorders."

"So instead of saying this is the way it is, this is so common, let's just make it normal. What we've done at Hinge Health is we've created a program that integrates pelvic healthcare into our digital clinic. It is a program that is created for women by women, and it allows women, those with vaginal anatomy, to enter the offering, to tell us what their needs are, and to get a customized experience for pelvic disorders in a holistic way."

@HingeHealth #WomensHealth #FemTech #PelvicHealth #PelvicFloor #PelvicFloorTherapy #DigitalHealth

hingehealth.com

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Inessa Lurye is the Senior Director of Consumer Product at Hinge Health, a digital musculoskeletal clinic with accessible digital physical therapy and whole-body care. Recently, Hinge has launched a Women's Pelvic Health program to personalize treatments for pelvic floor disorder and to expand access to pelvic floor physical therapy for underserved communities.

Inessa explains, "We span that entire continuum, and we offer individuals access to a personalized care team, which is in-house physical therapists and Board-certified coaches, and a digital product that includes exercise therapy and education to help free people from pain."

"We have personalized the experience to women and those with vaginal anatomy. One in four women has a pelvic floor disorder, and pelvic health is musculoskeletal health, but for so long, we haven't treated it as such. And so what we've done is, knowing that our clinic is a digital clinic that serves the whole person, we have personalized the experience for pelvic floor disorders."

"So instead of saying this is the way it is, this is so common, let's just make it normal. What we've done at Hinge Health is we've created a program that integrates pelvic healthcare into our digital clinic. It is a program that is created for women by women, and it allows women, those with vaginal anatomy, to enter the offering, to tell us what their needs are, and to get a customized experience for pelvic disorders in a holistic way."

@HingeHealth #WomensHealth #FemTech #PelvicHealth #PelvicFloor #PelvicFloorTherapy #DigitalHealth

hingehealth.com

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Jonathan Baktari MD is the Founder and CEO of e7 Health which specializes in seven areas of healthcare. The common theme is that adult vaccinations can have a significant impact on reducing vaccine-preventable deaths in these areas. Leveraging digital technology, e7 is reducing friction in the healthcare system and allowing patients to draw on a repository of their vaccine records to quickly get appropriate, quality care.

Jonathan explains, "A lot of times, for example, we see people who aren't sure if they had all their childhood vaccines. What we can offer people is to see if they have immunity to chicken pox varicella or if they have immunity to MMR or hepatitis B. And so, instead of just randomly getting the vaccines or not getting the vaccine, finding the people's status is helpful in making a determination of what they need. So we've offered that."

"We also offer STD testing. And the reason we do is that we offer several STD vaccines. And so if we're going to offer the vaccine, we're going to offer testing around it and other services. We just thought giving the vaccine without an understanding of whether someone necessarily needed the vaccine or didn't need the vaccine would be helpful."

"What we do is just remove all barriers. We write our own technology, our own software. So literally, you can, on your phone, get an appointment for that day and be seen that day. Whatever we do with you will be in your portal by the time you hit the parking lot. And that's our goal, that's what we try to do. And so, I think what we have noticed is if you reduce friction for the person, they're going to respond differently. A lot of people, say oh, I got to see my doctor, but there is a seven-week wait usually. And so I think those become barriers."

@e7_health #Vaccinations #AdultVaccinations #COVID #COVIDTesting #HealthTech #PrecisionMedicine

e7health.com

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Jonathan Baktari MD is the Founder and CEO of e7 Health which specializes in seven areas of healthcare. The common theme is that adult vaccinations can have a significant impact on reducing vaccine-preventable deaths in these areas. Leveraging digital technology, e7 is reducing friction in the healthcare system and allowing patients to draw on a repository of their vaccine records to quickly get appropriate, quality care.

Jonathan explains, "A lot of times, for example, we see people who aren't sure if they had all their childhood vaccines. What we can offer people is to see if they have immunity to chicken pox varicella or if they have immunity to MMR or hepatitis B. And so, instead of just randomly getting the vaccines or not getting the vaccine, finding the people's status is helpful in making a determination of what they need. So we've offered that."

"We also offer STD testing. And the reason we do is that we offer several STD vaccines. And so if we're going to offer the vaccine, we're going to offer testing around it and other services. We just thought giving the vaccine without an understanding of whether someone necessarily needed the vaccine or didn't need the vaccine would be helpful."

"What we do is just remove all barriers. We write our own technology, our own software. So literally, you can, on your phone, get an appointment for that day and be seen that day. Whatever we do with you will be in your portal by the time you hit the parking lot. And that's our goal, that's what we try to do. And so, I think what we have noticed is if you reduce friction for the person, they're going to respond differently. A lot of people, say oh, I got to see my doctor, but there is a seven-week wait usually. And so I think those become barriers."

@e7_health #Vaccinations #AdultVaccinations #COVID #COVIDTesting #HealthTech #PrecisionMedicine

e7health.com

Download the transcript here