Empowered Patient Podcast

Laurent Levy is the CEO of Nanobiotix, which is applying nanophysics to direct radiation therapy more efficiently to cancerous tumors while reducing the side effects of damage to surrounding tissue. This intratumoral injection of nanoparticles maximizes the concentration in the tumor and minimizes the rest of the body exposure. Starting with soft tissue sarcoma, they are expanding to head and neck cancer with plans for other indications like pancreatic, liver, and breast cancer.

Laurent explains, "We thought, at Nanobiotix, that we may find something different. Rather than making better radiation therapy equipment, we thought about the problem in a different way. We did develop a product that is an injectable that you will inject directly into the tumor. And, when the product is in the tumor -- they are based on nanoparticles, tiny objects -- these objects will go into the cell, and they will sit there. They'll do nothing until the patient is getting the usual radiation therapy."

"And we've been designing those objects to be able to absorb the energy of radiation. Therefore, when the patient is getting radiation, the x-ray will cross the cancer cell, and the nanoparticle in that cancer cell will absorb the energy and will deliver around them a high quantity of damage and will kill the cancer cell more efficiently."

@Nanobiotix #Nanomedicine #Nanophysics #Nanotechnology #Nanoparticles #RadiationTherapy #Cancer #SolidTumors #HeadandNeckCancer

Nanobiotix.com

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Laurent Levy is the CEO of Nanobiotix, which is applying nanophysics to direct radiation therapy more efficiently to cancerous tumors while reducing the side effects of damage to surrounding tissue. This intratumoral injection of nanoparticles maximizes the concentration in the tumor and minimizes the rest of the body exposure. Starting with soft tissue sarcoma, they are expanding to head and neck cancer with plans for other indications like pancreatic, liver, and breast cancer.

Laurent explains, "We thought, at Nanobiotix, that we may find something different. Rather than making better radiation therapy equipment, we thought about the problem in a different way. We did develop a product that is an injectable that you will inject directly into the tumor. And, when the product is in the tumor -- they are based on nanoparticles, tiny objects -- these objects will go into the cell, and they will sit there. They'll do nothing until the patient is getting the usual radiation therapy."

"And we've been designing those objects to be able to absorb the energy of radiation. Therefore, when the patient is getting radiation, the x-ray will cross the cancer cell, and the nanoparticle in that cancer cell will absorb the energy and will deliver around them a high quantity of damage and will kill the cancer cell more efficiently."

@Nanobiotix #Nanomedicine #Nanophysics #Nanotechnology #Nanoparticles #RadiationTherapy #Cancer #SolidTumors #HeadandNeckCancer

Nanobiotix.com

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Dr. Jacob Donoghue is the CEO and Co-Founder of Beacon Biosignals, a computational neurobiomarker discovery and deployment platform taking EEG readings and applying their algorithms to identify novel neurobiomarkers that might be related to a disease that can be modulated by a new therapy.

Jacob drills down, "We anchor these biomarkers that we are able to identify off the world's largest annotated EEG database, which we have at Beacon, to be able to really put things into context. When we make a discovery, we can really see, even in a small cohort of patients, how does that relate to both other patients with that related disease or also healthy normal patients?

"Beacon was born by looking at the massive opportunity and unmet need in patients with neurological and psychiatric diseases and to take in all these long data sets of electrical brain activity, EEG data, to be able to provide the same types of tools that were transforming digital pathology, radiology, and GI to better characterize diseases of the brain and help novel therapies make it through the clinical development process into patients."

"One of the traditional endpoints that persist in rare diseases for epilepsy is often the seizure diary, where you ask the parents, in the case of pediatric genetic epilepsy, you ask the parents to annotate either in a paper notebook or in an app when they see a visible event that resembles a seizure or is a seizure event."

"In some of the kids that we've started analyzing, we see that the patient reported seizures, the seizure diaries, will show only 10 or 20 seizures a day, but when you put an EEG on, you actually capture hundreds of seizures per day. And similarly, we have other kids where they're actually having 0 seizures a day, but the patient diaries often will report 10 or 20 seizures a day."

@biosignals #BeaconBiosignals #EEG #Epilepsy #RareDiseases #SleepDisorders #Neurology #NeurologicalDiseases #NeuroDegenerativeDiseases #PsychiatricDiseases #ML #MachineLearning

beacon.bio

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Dr. Jacob Donoghue is the CEO and Co-Founder of Beacon Biosignals, a computational neurobiomarker discovery and deployment platform taking EEG readings and applying their algorithms to identify novel neurobiomarkers that might be related to a disease that can be modulated by a new therapy.

Jacob drills down, "We anchor these biomarkers that we are able to identify off the world's largest annotated EEG database, which we have at Beacon, to be able to really put things into context. When we make a discovery, we can really see, even in a small cohort of patients, how does that relate to both other patients with that related disease or also healthy normal patients?

"Beacon was born by looking at the massive opportunity and unmet need in patients with neurological and psychiatric diseases and to take in all these long data sets of electrical brain activity, EEG data, to be able to provide the same types of tools that were transforming digital pathology, radiology, and GI to better characterize diseases of the brain and help novel therapies make it through the clinical development process into patients."

"One of the traditional endpoints that persist in rare diseases for epilepsy is often the seizure diary, where you ask the parents, in the case of pediatric genetic epilepsy, you ask the parents to annotate either in a paper notebook or in an app when they see a visible event that resembles a seizure or is a seizure event."

"In some of the kids that we've started analyzing, we see that the patient reported seizures, the seizure diaries, will show only 10 or 20 seizures a day, but when you put an EEG on, you actually capture hundreds of seizures per day. And similarly, we have other kids where they're actually having 0 seizures a day, but the patient diaries often will report 10 or 20 seizures a day."

@biosignals #BeaconBiosignals #EEG #Epilepsy #RareDiseases #SleepDisorders #Neurology #NeurologicalDiseases #NeuroDegenerativeDiseases #PsychiatricDiseases #ML #MachineLearning

beacon.bio

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Dr. Jennifer Jones-McMeans is a Divisional Vice President of Global Clinical Affairs at Abbott Vascular Business and she sheds light on the FDA guidance to encourage sponsors of clinical trials to include all genders, ethnicities, and under-represented patients to participate. New guidelines are more organized and provide better guidance for what sponsors of clinical trials should consider during their submissions to the FDA.

Jennifer explains, "If you think about where clinical trials sit, clinical trials are part of the overall healthcare ecosystem. And if we consider that the healthcare ecosystem is to be inclusive, it is to make sure that there are appropriate treatments for women and different ethnic groups. Also understanding that possibly there could be differences in maybe therapeutic responses, or even considering access too. Clinical trials have to then move forward as the medical ecosystem is moving forward to ensure that there's treatment available for all patients. And so this is where again, this guidance is just a guideline to help support that pathway for clinical trials."

"We do know that there are specific populations that, based on their access to health and lack of trust that can occur with the healthcare system, when it comes to clinical trials, they may actually not know and have an awareness of the clinical trial. But they also may not be connected with the appropriate medical system or within a medical system to even have that access. So that's some of the work that we know that the sponsors can do in reaching out."

@AbbottCardio #ClinicalTrials #FDAGuidance #UnderservedPatients #UnderrepresentedPatients #MinorityPatients

abbott.com

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Dr. Jennifer Jones-McMeans is a Divisional Vice President of Global Clinical Affairs at Abbott Vascular Business and she sheds light on the FDA guidance to encourage sponsors of clinical trials to include all genders, ethnicities, and under-represented patients to participate. New guidelines are more organized and provide better guidance for what sponsors of clinical trials should consider during their submissions to the FDA.

Jennifer explains, "If you think about where clinical trials sit, clinical trials are part of the overall healthcare ecosystem. And if we consider that the healthcare ecosystem is to be inclusive, it is to make sure that there are appropriate treatments for women and different ethnic groups. Also understanding that possibly there could be differences in maybe therapeutic responses, or even considering access too. Clinical trials have to then move forward as the medical ecosystem is moving forward to ensure that there's treatment available for all patients. And so this is where again, this guidance is just a guideline to help support that pathway for clinical trials."

"We do know that there are specific populations that, based on their access to health and lack of trust that can occur with the healthcare system, when it comes to clinical trials, they may actually not know and have an awareness of the clinical trial. But they also may not be connected with the appropriate medical system or within a medical system to even have that access. So that's some of the work that we know that the sponsors can do in reaching out."

@AbbottCardio #ClinicalTrials #FDAGuidance #UnderservedPatients #UnderrepresentedPatients #MinorityPatients

abbott.com

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Kathleen Aller is the Director of Market Strategy for Healthcare at InterSystems, a software company that focuses on high-volume data management and mobile applications to manage healthcare data. By taking advantage of the InterSystems capabilities on the AWS platform, young startup companies can use its technology to help them cost-effectively build interoperable applications or data-intensive applications and scale up as needed.

Kathleen explains, "In fact, there are more than a billion records managed in our technology. One of the groups we've been working with a lot in the last few years are payer organizations who are responding to government regulation that says you have to make the information you hold about patients available to them. You need to do it using a standard called FHIR, Fast Health Interoperability Resources. They have to be able, then, to import that data into applications so that they can do things with it."

"We've been involved in digital health practically since its inception. Some of that is managed in applications built by partners like Epic, like 3M, who use our data management platform at the center of what they do. Some of that is in applications that we build on our own platform, so our HealthShare Interoperability engine connects up records for citizens around the world and gives a seamless longitudinal record. Our TrakCare EHR is used outside the US to document and deliver care."

@InterSystems #AWS #DigitalHealth #Healthcare #MedicalApps #HealthcareApps #FHIR

InterSystems.com

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Kathleen Aller is the Director of Market Strategy for Healthcare at InterSystems, a software company that focuses on high-volume data management and mobile applications to manage healthcare data. By taking advantage of the InterSystems capabilities on the AWS platform, young startup companies can use its technology to help them cost-effectively build interoperable applications or data-intensive applications and scale up as needed.

Kathleen explains, "In fact, there are more than a billion records managed in our technology. One of the groups we've been working with a lot in the last few years are payer organizations who are responding to government regulation that says you have to make the information you hold about patients available to them. You need to do it using a standard called FHIR, Fast Health Interoperability Resources. They have to be able, then, to import that data into applications so that they can do things with it."

"We've been involved in digital health practically since its inception. Some of that is managed in applications built by partners like Epic, like 3M, who use our data management platform at the center of what they do. Some of that is in applications that we build on our own platform, so our HealthShare Interoperability engine connects up records for citizens around the world and gives a seamless longitudinal record. Our TrakCare EHR is used outside the US to document and deliver care."

@InterSystems #AWS #DigitalHealth #Healthcare #MedicalApps #HealthcareApps #FHIR

InterSystems.com

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Keith Palmer is the Worldwide Vice President for Hip Reconstruction at DePuy Synthes, which is the orthopedic company of Johnson & Johnson. DePuy Synthes is focused on adapting their technology, techniques, and implants to provide stability, flexibility, and durability to an ever more active patient population.

Keith reports, "When we think about our surgeons and our patients and keep them in mind, we have solutions that address unmet needs in patients that lead to improved outcomes. So, through our anterior advantage, our portfolio solutions, in particular, patients benefit from shorter hospital stays, quicker recovery times, and reduced use of pain medication when they're surgeon implants or comprehensive systems for hip replacement surgeries."

"Our patients today are highly educated on different surgical technique offerings. They even think about what's best in terms of meeting their needs, the quicker recovery, and even going to outpatient surgery centers and ensuring that the time is reduced to help them get back to their active lifestyle quicker. But they're continuously involved in goal planning with the surgeon to be able to address some of these needs."

@DePuySynthes #HipReplacement #HipReplacementSurgery

jnjmedtech.com

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Keith Palmer is the Worldwide Vice President for Hip Reconstruction at DePuy Synthes, which is the orthopedic company of Johnson & Johnson. DePuy Synthes is focused on adapting their technology, techniques, and implants to provide stability, flexibility, and durability to an ever more active patient population.

Keith reports, "When we think about our surgeons and our patients and keep them in mind, we have solutions that address unmet needs in patients that lead to improved outcomes. So, through our anterior advantage, our portfolio solutions, in particular, patients benefit from shorter hospital stays, quicker recovery times, and reduced use of pain medication when they're surgeon implants or comprehensive systems for hip replacement surgeries."

"Our patients today are highly educated on different surgical technique offerings. They even think about what's best in terms of meeting their needs, the quicker recovery, and even going to outpatient surgery centers and ensuring that the time is reduced to help them get back to their active lifestyle quicker. But they're continuously involved in goal planning with the surgeon to be able to address some of these needs."

@DePuySynthes #HipReplacement #HipReplacementSurgery

jnjmedtech.com

Download the transcript here