Empowered Patient Podcast

Alon Ben-Noon is the Co-Founder and CEO of NeuroSense Therapeutics, which is working on ALS therapy and other neurodegenerative diseases like Parkinson's and Alzheimer's disease. They are working on a disease-modifying drug PrimeC and have identified a large set of biomarkers that are related to ALS progression and the mechanisms of PrimeC.

Alon explains, "Our lead candidate is called PrimeC. It's a novel formulation that consists of two FDA-approved drugs not related to ALS. We found that when these drugs are combined together in unique doses, they had the quality to treat ALS and tackle ALS in several forms. This formulation aims to maximize the synergism that we found to have between these compounds and as I mentioned, to tackle multiple targets in order to eventually create a clinical benefit for the patients."

"We are advancing with identifying biomarkers and progressing there very nicely. We identified a large set of biomarkers that relates both to the disease progression and to the mechanisms of PrimeC. We work on neuron-derived exosomes, and when we first characterize the set of biomarkers that are relevant for us, we also explored how PrimeC, our lead candidate, can create a change in these biomarkers."

@NeuroSenseT #NeuroSense #Neurodegenerative #PrimeC #Biotech #RareDiseases #CNS #ALS #Alzheirmers #AD #Parkinsons #PD #Biomarkers

NeuroSense-TX.com

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Alon Ben-Noon is the Co-Founder and CEO of NeuroSense Therapeutics, which is working on ALS therapy and other neurodegenerative diseases like Parkinson's and Alzheimer's. They are working on a disease-modifying drug PrimeC and have identified a large set of biomarkers that are related to ALS progression and the mechanisms of PrimeC.

Alon explains, "Our lead candidate is called PrimeC. It's a novel formulation that consists of two FDA-approved drugs not related to ALS. We found that when these drugs are combined together in unique doses, they had the quality to treat ALS and tackle ALS in several forms. This formulation aims to maximize the synergism that we found to have between these compounds and as I mentioned, to tackle multiple targets in order to eventually create a clinical benefit for the patients."

"We are advancing with identifying biomarkers and progressing there very nicely. We identified a large set of biomarkers that relates both to the disease progression and to the mechanisms of PrimeC. We work on neuron-derived exosomes, and when we first characterize the set of biomarkers that are relevant for us, we also explored how PrimeC, our lead candidate, can create a change in these biomarkers."

@NeuroSenseT #NeuroSense #Neurodegenerative #PrimeC #Biotech #RareDiseases #CNS #ALS #Alzheirmers #AD #Parkinsons #PD #Biomarkers

NeuroSense-TX.com

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Dr. Maryann Lauletta is the Chief Medical Officer of Dina, re-imagining healthcare with a home-first model using technology and community-based solutions. Their 50-state network provides access to different providers of medical and home setting solutions to aid care coordinators in creating a safe home environment.

Maryann elaborates, "We have to realize that the home is not a controlled setting, as you experience in a hospital setting or a skilled nursing facility. There are a lot of things that pop up that you need to be prepared for. Patients may not have adequate equipment at home, and they may not have adequate access to food, heating, and cooling. There could be pest infestations. They need access to transportation. You need to figure out how to coordinate with sometimes four or five or more different providers and be able to share information about that patient in real-time and on the go. I think that's something we don't always talk about or realize."

"In the hospital, you're not worrying or necessarily even thinking about home modification needs, again, pest control, meal delivery, because you have that all under one roof. It's really been our goal to take into account all of the different needs that patients may encounter in the home and load those types of providers in our network so that we're basically prepared for any service that patients may need to be activated in a short amount of time."

@Dinacare_inc #aginginplace #CareatHome #CareCoordination #CMS #Healthcare #Homecare #PopulationHealth #Providers #RaH #SDoH #SkilledNursing #ValueBasedCare #WorkforceShortage #HealthTechnology #Medtech

Dinacare.com

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Dr. Maryann Lauletta is the Chief Medical Officer of Dina, re-imagining healthcare with a home-first model using technology and community-based solutions. Their 50-state network provides access to different providers of medical and home setting solutions to aid care coordinators in creating a safe home environment.

Maryann elaborates, "We have to realize that the home is not a controlled setting, as you experience in a hospital setting or a skilled nursing facility. There are a lot of things that pop up that you need to be prepared for. Patients may not have adequate equipment at home, and they may not have adequate access to food, heating, and cooling. There could be pest infestations. They need access to transportation. You need to figure out how to coordinate with sometimes four or five or more different providers and be able to share information about that patient in real-time and on the go. I think that's something we don't always talk about or realize."

"In the hospital, you're not worrying or necessarily even thinking about home modification needs, again, pest control, meal delivery, because you have that all under one roof. It's really been our goal to take into account all of the different needs that patients may encounter in the home and load those types of providers in our network so that we're basically prepared for any service that patients may need to be activated in a short amount of time."

@Dinacare_inc #aginginplace #CareatHome #CareCoordination #CMS #Healthcare #Homecare #PopulationHealth #Providers #RaH #SDoH #SkilledNursing #ValueBasedCare #WorkforceShortage #HealthTechnology #Medtech

Dinacare.com

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Enam Noor is the Founder and CEO of Insightin Health, empowering health plans to drive action through connected data. Working with health insurance companies with a focus on direct-to-consumer health plan products, Insightin is creating a data ecosystem that allows access by providers, payers, and patients. Using artificial intelligence and machine learning, that data can be used to design treatment plans using their Next Best Action strategy.

Enam explains, "We try to create real-time insight around that information to drive healthier behavior, improve the member engagement, the population health part of preventative care management. In the senior population, when it comes to Medicare, there are a lot of chronic conditions. Preventative care management plays a big role in staying healthy. In general, what our clients expect out of our involvement is building that lifetime member value and are really extracting the best way to be healthier. Then eventually, it's a win-win for everybody."

"Our platform has three main areas in terms of technology. The very first portion is the data connector, where in a very simple way, very quickly, both structured and unstructured data can be digested by our platform. We have machine learning AIs and natural language processing. We can take any sort of data. In healthcare, there's a lot of unstructured data, data that happens in phone conversations or notes field on the EHR."

@InsightinHealth #NextBestAction #HealthIT #AI #ML #MedicareAdvantage #CAPHS

insightinhealth.com

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Enam Noor is the Founder and CEO of Insightin Health, empowering health plans to drive action through connected data. Working with health insurance companies with a focus on direct-to-consumer health plan products, Insightin is creating a data ecosystem that allows access by providers, payers, and patients. Using artificial intelligence and machine learning, that data can be used to design treatment plans using their Next Best Action strategy.

Enam explains, "We try to create real-time insight around that information to drive healthier behavior, improve the member engagement, the population health part of preventative care management. In the senior population, when it comes to Medicare, there are a lot of chronic conditions. Preventative care management plays a big role in staying healthy. In general, what our clients expect out of our involvement is building that lifetime member value and are really extracting the best way to be healthier. Then eventually, it's a win-win for everybody."

"Our platform has three main areas in terms of technology. The very first portion is the data connector, where in a very simple way, very quickly, both structured and unstructured data can be digested by our platform. We have machine learning AIs and natural language processing. We can take any sort of data. In healthcare, there's a lot of unstructured data, data that happens in phone conversations or notes field on the EHR."

@InsightinHealth #NextBestAction #HealthIT #AI #ML #MedicareAdvantage #CAPHS

insightinhealth.com

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Michael Smith is the Chief Commercial Officer of Sonendo, a commercial-stage medtech company taking on saving teeth from tooth decay by driving changes in root canal surgery and outcomes. The GentleWave procedure brings innovation to root canal therapy by using a software-controlled fluid management system that can predictably clean and disinfect the inside of the tooth.

Michael elaborates, "If you think about dentistry, you can probably categorize it into three distinct segments -- those companies who move teeth, so the orthodontic companies, those who replace teeth, the implant companies, and then those who are focused on saving teeth. That's really been our focus. Tooth decay's the most prevalent chronic disease globally. So our mission is to save teeth and improve lives."

"I think that the reality is that root canal therapy is an end-stage of the disease state. It starts with something that's much more minor. The alternative really is that the tooth is extracted. So any technology that can improve that patient experience takes away some of the anxiety that patients have around either going to the dentist, the endodontist or having a root canal therapy. You can imagine how easy that is for patients to relate to it. And we feel that not only is this a significant market, but the technology that we have makes a real difference to the patient experience, but also the way the doctors treat it as well."

#Sonendo #GentleWave #GentleWaveProcedure #Endodontics #RootCanal #RootCanalTherapy #RootCanalSurgery #ToothDecay #Teeth #OralHealth

Sonendo.com

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Michael Smith is the Chief Commercial Officer of Sonendo, a commercial-stage medtech company taking on saving teeth from tooth decay by driving changes in root canal surgery and outcomes. The GentleWave procedure brings innovation to root canal therapy by using a software-controlled fluid management system that can predictably clean and disinfect the inside of the tooth.

Michael elaborates, "If you think about dentistry, you can probably categorize it into three distinct segments -- those companies who move teeth, so the orthodontic companies, those who replace teeth, the implant companies, and then those who are focused on saving teeth. That's really been our focus. Tooth decay's the most prevalent chronic disease globally. So our mission is to save teeth and improve lives."

"I think that the reality is that root canal therapy is an end-stage of the disease state. It starts with something that's much more minor. The alternative really is that the tooth is extracted. So any technology that can improve that patient experience takes away some of the anxiety that patients have around either going to the dentist, the endodontist or having a root canal therapy. You can imagine how easy that is for patients to relate to it. And we feel that not only is this a significant market, but the technology that we have makes a real difference to the patient experience, but also the way the doctors treat it as well."

#Sonendo #GentleWave #GentleWaveProcedure #Endodontics #RootCanal #RootCanalTherapy #RootCanalSurgery #ToothDecay #Teeth #OralHealth

Sonendo.com

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Dr. John Bellettiere is the assistant professor of epidemiology at the Herbert Wertheim School of Public Health and Human Longevity Science at UC San Diego. Alexis Garduno is a third-year student in the UC San Diego and San Diego State University joint doctoral program in public health and the first author in a multi-institutional research effort better to understand the impact of physical activity on health. Their recently released study analyzed data about the total steps taken per day, the intensity of the walking, and the risk of development of Type 2 diabetes in postmenopausal women. Study results indicated that for each 2,000 additional steps per day, there was a 12% reduction in diabetes risk.

John elaborates, "Well, we set out to understand how steps per day was related to incident diabetes in older women. Long have we known that physical activity is important for the prevention of chronic diseases, such as diabetes and cardiovascular disease. But for a long time, we have not been able to measure with good accuracy the everyday movements that people make. Previously, we had to ask individuals how much physical activity do you engage in on a given day. And so, with those self-reports, it's hard for people to remember and give good estimates. And we also don't get high resolution on how many steps they're able to take."

Alexis explains, "We followed these women for up to approximately 6.9 years, and we had questionnaire data about their medical history, which we also validated with a physician diagnosis and showed high agreement between the physician diagnosis and the questionnaire data. And then all of our physical activity measures were taken from these women wearing the accelerometer."

"It's important to think about where you're at and any increase in your daily movement, whether that's remembering to take an extra walk around the block or starting off your morning a little bit more active. All of those steps will make a difference regardless of how active you are at the starting point."

@JohnBellettiere @Garduno_Alexis #Type2Diabetes #Diabetes #HealthyAging #Accelerometer

Study published in Diabetes Care

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Dr. John Bellettiere is the assistant professor of epidemiology at the Herbert Wertheim School of Public Health and Human Longevity Science at UC San Diego. Alexis Garduno is a third-year student in the UC San Diego and San Diego State University joint doctoral program in public health and the first author in a multi-institutional research effort better to understand the impact of physical activity on health. Their recently released study analyzed data about the total steps taken per day, the intensity of the walking, and the risk of development of Type 2 diabetes in postmenopausal women. Study results indicated that for each 2,000 additional steps per day, there was a 12% reduction in diabetes risk.

John elaborates, "Well, we set out to understand how steps per day was related to incident diabetes in older women. Long have we known that physical activity is important for the prevention of chronic diseases, such as diabetes and cardiovascular disease. But for a long time, we have not been able to measure with good accuracy the everyday movements that people make. Previously, we had to ask individuals how much physical activity do you engage in on a given day. And so, with those self-reports, it's hard for people to remember and give good estimates. And we also don't get high resolution on how many steps they're able to take."

Alexis explains, "We followed these women for up to approximately 6.9 years, and we had questionnaire data about their medical history, which we also validated with a physician diagnosis and showed high agreement between the physician diagnosis and the questionnaire data. And then all of our physical activity measures were taken from these women wearing the accelerometer."

"It's important to think about where you're at and any increase in your daily movement, whether that's remembering to take an extra walk around the block or starting off your morning a little bit more active. All of those steps will make a difference regardless of how active you are at the starting point."

@JohnBellettiere @Garduno_Alexis #Type2Diabetes #Diabetes #HealthyAging #Accelerometer

Study published in Diabetes Care

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