Empowered Patient Podcast

Craig Parker is the CEO of Surrozen, experts in the Wnt pathway which is one of the fundamental pathways that help to establish the structure of organs, renewal of stem cells, and recovery from injury. This is a story of discovering the right combination of their tissue-specific approach and the right molecules to enhance or activate the Wnt pathway.

Craig elaborates, "So, in the liver, for example, when we injure our liver by drinking too much alcohol, the Wnt pathway is activated and is really the key pathway that's responsible for the regeneration that we're all able to stimulate in our liver."

"There are many, many other organs where the Wnt pathway is known to play a role in how that particular organ is maintained and responds to injury. So, what we're trying to do is take advantage of that biology that's so important in all of us during development and in adulthood and to stimulate it in a very selective way to get organs like the liver or the intestine or the retina to regenerate in response to the injury that certain diseases caused to that tissue."

"When you have biology that's so powerful, and that is so relevant in different organs, the challenge, really, probably the most fundamental challenge, is to utilize it or activate it only in the tissue that you want, only in the tissue that you're targeting for a specific disease. We don't want to activate this pathway throughout the body. So, it's that selective approach that really distinguishes our technology and our approach, and that was really an impediment to utilizing this pathway over the last 30 years."

#Surrozen #WntPathway #Wnt #WntBiology #WntSignaling #SevereAlcoholicHepatitis #LiverCells #IBD #TissueRepair #Biotech #FrizzledReceptors #ZincFIngers #ClinicalDevelopment

Surrozen.com

Listen to the podcast here

Craig Parker is the CEO of Surrozen, experts in the Wnt pathway, which is one of the fundamental pathways that help to establish the structure of organs, renewal of stem cells, and recovery from injury. This is a story of discovering the right combination of their tissue-specific approach and the right molecules to enhance or activate the Wnt pathway.

Craig elaborates, "So, in the liver, for example, when we injure our liver by drinking too much alcohol, the Wnt pathway is activated and is really the key pathway that's responsible for the regeneration that we're all able to stimulate in our liver."

"There are many, many other organs where the Wnt pathway is known to play a role in how that particular organ is maintained and responds to injury. So, what we're trying to do is take advantage of that biology that's so important in all of us during development and in adulthood and to stimulate it in a very selective way to get organs like the liver or the intestine or the retina to regenerate in response to the injury that certain diseases caused to that tissue."

"When you have biology that's so powerful, and that is so relevant in different organs, the challenge, really, probably the most fundamental challenge, is to utilize it or activate it only in the tissue that you want, only in the tissue that you're targeting for a specific disease. We don't want to activate this pathway throughout the body. So, it's that selective approach that really distinguishes our technology and our approach, and that was really an impediment to utilizing this pathway over the last 30 years."

#Surrozen #WntPathway #Wnt #WntBiology #WntSignaling #SevereAlcoholicHepatitis #LiverCells #IBD #TissueRepair #Biotech #FrizzledReceptors #ZincFIngers #ClinicalDevelopment

Surrozen.com

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George Georgallides is the Founder of Basis, a start-up that is taking an advanced view of helping patients achieve better health and reach health and fitness goals. Integrating data from a wide range of sources, Basis is striving for a real-time approach to engaging patients in making small but significant adjustments as they go through their day.

George explains, "So, what we've essentially built is the unique integrative approach to help them that combines all this information that we're getting. We're actually addressing and combining it with workout, nutrition, mindfulness, and sleep in one platform. Those are things that exist in silos. The data exists in unstructured and incomprehensible ways for the person."

"We've structured all those things around specific health goals. My background is in bioinformatics. My team is data scientists and health experts from universities and programs. So, we have an amazing team, and we've been able to build very interesting models around data that most people don't really have much use for. Most people don't really understand how to put a resting heart rate or heart rate variability as a number into affecting their day-to-day life. So, we take that obscurity of that, and we put that into a specific, actionable task. So, how does it influence recovery? How does your sleep last night influence how you should eat, exercise, the level of activity you have today?

@Basis_Health #Healthcare #Fitness #WearableTech #DigitalHealth #HealthandWellness #AI #Startups #Entrepreneur

BasisHealth.io

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George Georgallides is the Founder of Basis, a start-up that is taking an advanced view of helping patients achieve better health and reach health and fitness goals. Integrating data from a wide range of sources, Basis is striving for a real-time approach to engaging patients in making small but significant adjustments as they go through their day.

George explains, "So, what we've essentially built is the unique integrative approach to help them that combines all this information that we're getting. We're actually addressing and combining it with workout, nutrition, mindfulness, and sleep in one platform. Those are things that exist in silos. The data exists in unstructured and incomprehensible ways for the person."

"We've structured all those things around specific health goals. My background is in bioinformatics. My team is data scientists and health experts from universities and programs. So, we have an amazing team, and we've been able to build very interesting models around data that most people don't really have much use for. Most people don't really understand how to put a resting heart rate or heart rate variability as a number into affecting their day-to-day life. So, we take that obscurity of that, and we put that into a specific, actionable task. So, how does it influence recovery? How does your sleep last night influence how you should eat, exercise, the level of activity you have today?

@Basis_Health #Healthcare #Fitness #WearableTech #DigitalHealth #HealthandWellness #AI #Startups #Entrepreneur

BasisHealth.io

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Dr. Jim Feng is the CEO and Founder of Phyxable which is serving up curated content specific to an injury or chronic condition to help patients overcome physical pain. Using a virtual approach, Phyxable is engaging patients with gamification and social media type notifications to keep people on a plan and encourage them to not drop off.

Jim elaborates, "We actually combine it with some machine learning algorithms to personalize the solution for you. And along the way, we also found that good guidance and coaching still play a good part in recovery, so we provide that service as well."

"And the last point, we're actually building on the high technology side in the augmented reality part. So, there's one side to understanding where you're at and what you need to do. But the other aspect of it is checking in to make sure you're actually doing it right on a daily basis. We're utilizing augmented reality technology just on your phone camera in order to provide the feedback in real-time."

@Phyxable #Health #Pain #Telehealth #Physiotherapy #Chiropractic #PhysicalTherapy #OnlineCoaching #OnlineCoach #OnlineTherapy #Entrepreneur

Phyxable.com

Listen to the podcast here

Dr. Jim Feng is the CEO and Founder of Phyxable which is serving up curated content specific to an injury or chronic condition to help patients overcome physical pain. Using a virtual approach, Phyxable is engaging patients with gamification and social media type notifications to keep people on a plan and encourage them to not drop off.

Jim elaborates, "We actually combine it with some machine learning algorithms to personalize the solution for you. And along the way, we also found that good guidance and coaching still play a good part in recovery, so we provide that service as well."

"And the last point, we're actually building on the high technology side in the augmented reality part. So, there's one side to understanding where you're at and what you need to do. But the other aspect of it is checking in to make sure you're actually doing it right on a daily basis. We're utilizing augmented reality technology just on your phone camera in order to provide the feedback in real-time."

@Phyxable #Health #Pain #Telehealth #Physiotherapy #Chiropractic #PhysicalTherapy #OnlineCoaching #OnlineCoach #OnlineTherapy #Entrepreneur

Phyxable.com

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Dr. Ketan Patel is the Chief Medical Officer at SyTrue which has taken on the challenge of modernizing the exchange of information between providers and insurance companies. Transitioning from a traditional system designed for reactive healthcare to one of preventative care means information flow and analysis need to change as well.

Ketan explains, "As we start thinking about healthcare in the next few decades, it's really about receiving value back from the money we see spent. It's about getting involved earlier, looking at those risk factors at a really early stage when the intervention can cost a 10th or a 20th of what it might cost later in life. And that's a paradigm shift, and our systems aren't really created for that. They were never designed for that kind of thinking. And we now realize this is important, and we have to do this. This is where there's a need for technology to get to that information, but there's also a need to look at that information differently."

"So, structured data, I'll start with that one, is information that is very succinct, it's defined. It's like a measurement coming off of a machine. It's easy to put that piece of information or data into a field inside of a computer or in a database.

"Unstructured information is things like a narrative note, a consultation report from a specialist that a patient goes and sees, and at the end of it, could be a five or six-page note. And there's a lot of words, a lot of phrases, a lot of paragraphs. Intermixed inside of that could also be other types of information like lab information, imaging report information, or a genetic study, for example."

@SyTrue #SyTrue #UnstructuredData #NLP #NaturalLanguageProcessing #COVID #DigitalHealth #MedTech #ElectronicHealthRecords

sytrue.com

Listen to the podcast here

Dr. Ketan Patel is the Chief Medical Officer at SyTrue which has taken on the challenge of modernizing the exchange of information between providers and insurance companies. Transitioning from a traditional system designed for reactive healthcare to one of preventative care means information flow and analysis need to change as well.

Ketan explains, "As we start thinking about healthcare in the next few decades, it's really about receiving value back from the money we see spent. It's about getting involved earlier, looking at those risk factors at a really early stage when the intervention can cost a 10th or a 20th of what it might cost later in life. And that's a paradigm shift, and our systems aren't really created for that. They were never designed for that kind of thinking. And we now realize this is important, and we have to do this. This is where there's a need for technology to get to that information, but there's also a need to look at that information differently."

"So, structured data, I'll start with that one, is information that is very succinct, it's defined. It's like a measurement coming off of a machine. It's easy to put that piece of information or data into a field inside of a computer or in a database.

"Unstructured information is things like a narrative note, a consultation report from a specialist that a patient goes and sees, and at the end of it, could be a five or six-page note. And there's a lot of words, a lot of phrases, a lot of paragraphs. Intermixed inside of that could also be other types of information like lab information, imaging report information, or a genetic study, for example."

@SyTrue #SyTrue #UnstructuredData #NLP #NaturalLanguageProcessing #COVID #DigitalHealth #MedTech #ElectronicHealthRecords

sytrue.com

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Dr. Josh Liu is the CEO and Co-Founder of SeamlessMD is working with care providers to safely discharge patients home sooner by at-home monitoring to track progress and reduce readmission rates. This allows hospitals to free up beds so they can actually see more patients, get more surgeries and other inpatient care done sooner.

Josh elaborates, "Where SeamlessMD is differentiated from other patient engagement solutions is that we think of ourselves as more of a digital care journey platform. So the idea is that we work with hospitals and health systems to engage, monitor, and stay connected with patients across this entire healthcare journey when you're going through something like a surgery, a cancer journey, or chronic care journey."

"The funny thing is when we first started SeamlessMD about nine years ago, just by chance, we focused initially on the older, higher risk, the complex patient population in their sixties, seventies, or eighties. So from day one, we had chosen to design this for the most challenged population when it comes to technology. Because of that, it's now very easy for all populations to use. And so we see all ages from the early twenties all the way up to the nineties."

@SeamlessMD #SeamlessMD #PatientEngagement #DigitalHealth #HealthTech

seamless.md

Listen to the podcast here

Dr. Josh Liu is the CEO and Co-Founder of SeamlessMD is working with care providers to safely discharge patients home sooner by at-home monitoring to track progress and reduce readmission rates. This allows hospitals to free up beds so they can actually see more patients, get more surgeries and other inpatient care done sooner.

Josh elaborates, "Where SeamlessMD is differentiated from other patient engagement solutions is that we think of ourselves as more of a digital care journey platform. So the idea is that we work with hospitals and health systems to engage, monitor, and stay connected with patients across this entire healthcare journey when you're going through something like a surgery, a cancer journey, or chronic care journey."

"The funny thing is when we first started SeamlessMD about nine years ago, just by chance, we focused initially on the older, higher risk, the complex patient population in their sixties, seventies, or eighties. So from day one, we had chosen to design this for the most challenged population when it comes to technology. Because of that, it's now very easy for all populations to use. And so we see all ages from the early twenties all the way up to the nineties."

@SeamlessMD #SeamlessMD #PatientEngagement #DigitalHealth #HealthTech

seamless.md

Download the transcript here