Research shows that suppressing melatonin production through excessive night lighting, especially blue light, leads health effects including an increase in certain endocrine-related carcinomas. It is now well known that circadian disturbance causes a 20–30% increase in breast cancer rates, and a similar increase in prostate cancers. We discuss the nexus between light pollution and human health, the environment, and public safety with part-time Naples resident, Dr. Mario Motta.