The endocannabinoid system can seem like a magical engine sometimes and, as cannabis enthusiasts, it's good to dig in and learn how it actually functions. On this episode of Shaping Fire, host Shango Los talks with cannabinoid scientist Miyabe Shields PhD about the chemical mechanics at the basis of our endocannabinoid system, including how cannabinoid receptors function, how cannabinoids take action, why we develop THC tolerance and how to manage it, and the effectiveness of whole plant versus single molecule cannabis medicine.