This systematic review and meta-analysis explores the complex relationship between metabolic disorders and the development of tendinopathies at various anatomical sites.

The research identifies diabetes as a major risk factor, significantly increasing the likelihood of developing Achilles tendinopathy and several upper limb conditions like trigger finger.

Furthermore, the study examines how dyslipidaemia, high body mass index (BMI), and the use of statin medications influence tendon health and structural integrity.

The authors also highlight sex-based differences, noting that men with high cholesterol face greater risks of tendon pathology while diabetic women are more prone to specific hand injuries.

Ultimately, the findings suggest that metabolic health is a critical component of tendon homeostasis, necessitating regular evaluations for patients with chronic pain or overuse injuries.

This comprehensive analysis underscores the multifactorial nature of tendon issues, advocating for integrated clinical management that addresses systemic metabolic factors.

(De Luca P, Grieco G, Bargeri S, Colombo C, Guida S, Taiana MM, et al. The interplay between metabolic disorders and tendinopathies: Systematic review and meta-analysis. J Exp Orthop [Internet]. 2025;12(3):e70429. Available from: http://dx.doi.org/10.1002/jeo2.70429)