喉科學專題：前路頸椎術後吞嚥與聲音評估(SR入路,PMID:42200633,https://pubmed.ncbi.nlm.nih.gov/42200633/) | 左側聲帶麻痺竟是主動脈瘤表現！(黴菌性動脈瘤,PMID:42206081,https://pubmed.ncbi.nlm.nih.gov/42206081/) | 咳嗽病理生理學綜述(神經免疫失調,PMID:42203561,https://pubmed.ncbi.nlm.nih.gov/42203561/)

維生素D與頭頸癌特輯：UNESCO乳癌RCT維生素D化療(PMID:40098326,https://pubmed.ncbi.nlm.nih.gov/40098326/) | 維生素D增進cisplatin敏感性LCN2/NF-κB(PMID:31819048,https://pubmed.ncbi.nlm.nih.gov/31819048/) | VDR-BIM克服cisplatin抗藥HNSCC(PMID:36291915,https://pubmed.ncbi.nlm.nih.gov/36291915/) | 維生素D缺乏HNSCC預後免疫(PMID:30228945,https://pubmed.ncbi.nlm.nih.gov/30228945/) | 術前25(OH)D與喉切除術後併發症(PMID:39438295,https://pubmed.ncbi.nlm.nih.gov/39438295/) | 維生素D與HNC統合分析(PMID:33732250,https://pubmed.ncbi.nlm.nih.gov/33732250/) | 維生素D頭頸癌臨床預後系統回顧(PMID:40218858,https://pubmed.ncbi.nlm.nih.gov/40218858/) | 維生素D頭頸癌綜論(PMID:37299554,https://pubmed.ncbi.nlm.nih.gov/37299554/)

睡眠醫學專題：OSA-CV綜論(PMID:42200975,https://pubmed.ncbi.nlm.nih.gov/42200975/) | CPAP預防心血管事件統合分析(PMID:42110829,https://pubmed.ncbi.nlm.nih.gov/42110829/) | CBT-I合併BZD減量(PMID:42168527,https://pubmed.ncbi.nlm.nih.gov/42168527/) | 數位CBT-I降低過度警醒(PMID:42184726,https://pubmed.ncbi.nlm.nih.gov/42184726/) | OSA種族差異系統性回顧(PMID:42196707,https://pubmed.ncbi.nlm.nih.gov/42196707/)

ENT特輯：2026年5月一週學術精選 | CRSwNP七種生物製劑網絡統合分析(PMID:41999554,https://pubmed.ncbi.nlm.nih.gov/41999554/) | TCRF鼻閥阻塞治療24個月睡眠追蹤(DOI:10.1002/oto2.70250,https://doi.org/10.1002/oto2.70250) | 頭頸癌放療中斷7天預後影響(PMCID:PMC12679426,https://pmc.ncbi.nlm.nih.gov/articles/PMC12679426/) | 頭頸癌輔助治療時效性JAMA Oto(PMCID:PMC13087907,https://pmc.ncbi.nlm.nih.gov/articles/PMC13087907/) | TMB預測HNSCC免疫治療反應統合分析(DOI:10.1002/hed.70297,https://doi.org/10.1002/hed.70297) | 頭頸癌系統治療未來十年藍圖(DOI:10.3389/fonc.2026.1799378,https://www.frontiersin.org/articles/10.3389/fonc.2026.1799378/full) | OSA自然病程跨生命週期綜述(MDPI,https://www.mdpi.com/2227-9032/14/3/325) | 會厭形態與OSA氣道塌陷CFD研究(MDPI,https://www.mdpi.com/2227-9059/14/3/553)

鼻科學專題：鼻息肉術後復發分層治療(PMID:42179747, DOI:10.62347/KYDI9328) | 單側鼻竇疾病良惡性鑑別演算法(PMID:42184393, DOI:10.24875/CIRU.24000449) | 薑製劑治療過敏性鼻炎統合分析(PMID:42183789, DOI:10.1080/13880209.2026.2667560) | Montelukast+desloratadine過敏性鼻炎網路統合分析(PMID:42182608)

ENT Update Podcast 2026-05-26 (Tuesday). Topics: ISSNHL vestibular assessment, Koos grade 4 VS SRS pseudoprogression, facial palsy QoL in VS patients, Spanish VADL cross-cultural adaptation. Hosts: Dr. Fu (Puck) & Dr. Lin (Kore).

ENT Update Podcast EP53 - Otology and Audiology (2026/05/26)

Papers discussed:

1. vHIT and cVEMPs in sudden SNHL - Rodriguez-Izquierdo et al. Acta Otolaryngol 2026 - DOI:10.1080/00016489.2026.2671348

2. Motorized vs manual CI insertion - Hear Res 2026 - DOI:10.1016/j.heares.2026.109653

3. Pseudoprogression in Koos grade 4 VS after SRS - Schouten et al. J Neurooncol 2026 - DOI:10.1007/s11060-026-05619-y

4. Facial palsy impact on VS QoL - van Vollenhoven et al. Otolaryngol Head Neck Surg 2026 - DOI:10.1002/ohn.70255

ENT Update Podcast EP52 - 頭頸外科與腫瘤學（2026/05/25）

本集論文：

1⃣️ Near-infrared fluorescence imaging-guided surgery using cRGD-ZW800 to improve surgical resection margins in oral cancer: a phase I/II feasibility trial

PMID: 42173866 https://pubmed.ncbi.nlm.nih.gov/42173866/

DOI: 10.1038/s41467-026-73554-7

關鍵發現：Phase I/II trial (n=24) 顯示 cRGD-ZW800 螢光導引可即時改變口腔癌手術邊緣決策，四例病人中偵測到肉眼無法辨識的腫瘤殘留

2⃣️ De-Escalated Adjuvant Radiation Therapy in Patients With HPV-Positive Oropharyngeal Cancer

PMID: 42149594 https://pubmed.ncbi.nlm.nih.gov/42149594/

DOI: 10.1001/jamanetworkopen.2026.12837

關鍵發現：NCDB 資料庫 3300+ 病人，降階放療組兩年局部控制率 93%，急性三度黏膜炎從 42% 降至 18%

3⃣️ Dissociating recurrence risk from mortality: a 10 year analysis challenging the independent prognostic value of depth of invasion in oral cavity squamous cell carcinoma

PMID: 42107224 https://pubmed.ncbi.nlm.nih.gov/42107224/

DOI: 10.1016/j.oraloncology.2026.108001

關鍵發現：多變項分析中 DOI 獨立預後價值大幅衰減（HR 2.1→1.3），不應單獨用於治療決策

4⃣️ Transoral Robotic Surgery-Based Treatment Versus Definitive Chemoradiation for Oropharyngeal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis

PMID: 42087273 https://pubmed.ncbi.nlm.nih.gov/42087273/

DOI: 10.1002/hed.70308

關鍵發現：TORS 組五年存活率 88% vs 放化療 85%（無顯著差異），但吞嚥功能與口乾發生率顯著較優

5⃣️ The submental artery pedicled flap for peri-auricular and parotid reconstruction: a comparative cohort

PMID: 42176358 https://pubmed.ncbi.nlm.nih.gov/42176358/

DOI: 10.1016/j.oraloncology.2026.108032

關鍵發現：頦下動脈皮瓣 vs 顳肌皮瓣，美觀滿意度更高、手術時間縮短 40 分鐘、住院天數更短，皮瓣存活率 100%

6⃣️ Osteoradionecrosis After Modern Radiotherapy for Oral Cavity Cancer: Incidence and Risk Factors

PMID: 42111429 https://pubmed.ncbi.nlm.nih.gov/42111429/

DOI: 10.1002/lio2.70431

關鍵發現：IMRT/VMAT 時代五年 ORN 累積發生率 7.2%，重度 ORN 2.8%；關鍵風險因子：下齒齦原發腫瘤、V6025%、放療前拔牙

Episode 51-Special | 2026/05/25 — 頭頸部腫瘤最新研究特輯

主持人：傅醫師（Puck）& 林醫師（Kore）

本集論文：

1. 單細胞 HNSCC 惡性細胞異質性與 MCScore 預測工具 (IUBMB Life)

DOI: https://pubmed.ncbi.nlm.nih.gov/42068156/

2. STING 表現預測 LA HNSCC 治療失敗型態 (JNCI Cancer Spectrum)

DOI: https://pubmed.ncbi.nlm.nih.gov/41569294/

3. HYDRA/HYPNO 低分割放療試驗

DOI (HYDRA): https://pubmed.ncbi.nlm.nih.gov/42000366/

DOI (HYPNO): https://pubmed.ncbi.nlm.nih.gov/41711624/

4. ctDNA MRD 監測：MERIDIAN Phase II + PECAN Trial (AACR 2026)

5. 放療中斷對預後影響 + SBRT 新技術 (JAMA Otolaryngology)

DOI: https://pmc.ncbi.nlm.nih.gov/articles/PMC12679426/

6. Rilvegostomig (TIGIT/PD-1) + MICVO ADC (AACR 2026)

7. HPV+ OPSCC 去強度策略與生物標記

DOI: https://onlinelibrary.wiley.com/doi/10.1002/cnr2.70539

ENT Update, Episode 47 | 2026/05/25. ENT Head and Neck Medicine latest information.