Tumor lysis syndrome (TLS) is an oncologic emergency that can unfold fast—and nurses are on the front line of catching it early. In this episode, Dr. Morgan Taylor, DNP, CPNP, CCRN, breaks down the cellular chaos that occurs when high-dose chemotherapy causes rapid tumor cell destruction, leading to a flood of intracellular contents and dangerous metabolic complications. 

From muscle cramps and tingling lips to sudden confusion and bradycardia, Morgan walks you through the signs of TLS, the critical labs to monitor, and a real case where quick ICU intervention made all the difference. Learn the essential nursing priorities to protect the kidneys, stabilize the heart, and manage electrolyte abnormalities—plus, get a breakdown of a high-yield NCLEX-style select-all-that-apply question. 

Topics discussed in this episode: 

• What tumor lysis syndrome is and why it’s an oncologic emergency 

• Electrolyte imbalances: hyperkalemia, hyperphosphatemia, and hypocalcemia 

• Kidney damage and the role of uric acid crystals in acute kidney injury 

• A real ICU case triggered by third-line chemo for a mediastinal mass 

• Priority nursing interventions for TLS management 

• Why telemetry and aggressive lab monitoring are key 

• Breaking down a high-yield NCLEX-style SATA question on TLS labs 

This episode is packed with clinical pearls and practical takeaways to help you recognize, respond to, and prevent the worst outcomes of TLS. Tune in now to sharpen your nursing instincts and NCLEX prep! 

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