Dr. Kashey talks about the importance of muscle and insulin in sugar disposal and the role of the liver in regulating blood sugar levels. Dr. Kashey discusses the mechanisms behind diabetes, insulin resistance, and glucose intolerance, explaining that high insulin levels can cause organs to build up a tolerance, leading to insulin resistance and, eventually, glucose intolerance. He argues that this can result in malnourishment and diabetes, which can cause nerve damage and organ failure. He also emphasizes the importance of local nutrient cycling in maintaining metabolic health, highlighting the complementary roles of exercise and diet in promoting fat loss and metabolic health.