Brian Shaffer was in his second year of medical school and had just finished his midterms and start spring break. Brian and his buddy decide to go out for a night of bar hopping to celebrate. At 2am, when the bar closes, Brian is no where to be seen. When he doesn't show up for his trip 3 days later, the police get involved. Video surveillance shows Brian entering the bar, but never exiting. How does someone disappear out of thin air? 

Resources:

Episode 6 of The Missing on Discovery