56. What’s the Best Ketamine Delivery Method? A Guide to At-Home and Clinical Options

What’s the difference between IV ketamine and lozenges? Should you choose FieldTrip’s full-service protocol—or Keta MD’s app-based model? This episode breaks it all down. Host April Pride is joined by medical professionals and industry veterans to compare four ketamine delivery methods—IM, IV, lozenges, and nasal spray. From bioavailability to budget, each option offers unique benefits (and tradeoffs). You’ll also hear firsthand experiences, learn what doctors look for when prescribing, and get practical “trip tips” to start your own research. Whether you’re dealing with treatment-resistant depression or simply curious about optimization, this is the essential guide for anyone exploring at-home ketamine therapy.

🔵 Key Takeaways

-At-home ketamine therapy options like lozenges are affordable and accessible—but lower in potency and bioavailability than clinical methods.

-IV and IM offer the highest absorption rates and fastest onset, but can be physically uncomfortable or cost-prohibitive.

-Nasal spray (Spravato) is FDA-approved and more likely to be covered by insurance—but less potent than other forms.

-“Optimization” means using low-dose psychedelics to improve creativity, mood, or stamina—even without a formal diagnosis.

-Platforms like WonderMed and Keta MD are reshaping access through telehealth, but integration support is key to long-term outcomes.

Learn more about this episode, including guests and resources on substack:https://aprilpride.substack.com/p/at-home-ketamine-therapy

Hosted by April Pride

Sign up for April’s newsletter on Substack at https://aprilpride.substack.com/ or at getsetset.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Follow on IG: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@getsetset⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ / YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠youtube.com/@getsetset⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ / X: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@getsetset

Get full access to SetSet with April Pride at aprilpride.substack.com/subscribe