64. When the Shrooms Don’t Hit: What Kills Magic Mushroom Potency?

What happens when you take a “strong” mushroom strain and feel… nothing? In this episode of The High Guide, host April Pride shares a frustrating but enlightening trip report on Thrasher PE, a Penis Envy derivative that failed to deliver. She walks us through her personal experience (and the awkward text exchange with her former mushroom cultivator), explains how psilocybin potency can degrade, and offers trip tips to keep your stash fresh. If you’ve ever wondered why your dose didn’t hit—or how to avoid wasting good mushrooms—this episode’s for you.

🔵 Key Takeaways

-Not all mushrooms are created—or stored—equally. Potency can degrade due to heat, light, and oxygen exposure.

-A strain’s reputation doesn’t guarantee a good trip. Thrasher PE (a Penis Envy variant) delivered nothing but disappointment for April and four friends.

-Cultivation and storage matter. Mushroom “drug dealers” aren't always reliable about quality control.

-Dosing method impacts outcomes. Mixing psilocybin with dairy-free ice cream may have affected absorption.

-Trip tips include how to store psilocybin for max potency. Think cool, dark, airtight, and properly dried.

Learn more about this episode, including guests and resources on substack:https://aprilpride.substack.com/p/what-kills-magic-mushroom-potency

Hosted by April Pride

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