Back in episode 80 we discussed a feasibility study out of Salt Lake City that showed IM epi resulted in 3-minute faster administration in cardiac arrest. It was underpowered to show survival, however. Fortunately, the great folks in Salt Lake City is back with a larger bite at the statistical apple. Dr Jarvis discusses the background around what we know about epinephrine in cardiac arrest (briefly, for once), walks us through this new study, and puts it in context of modern clinical practice. 

Citations.

1. Palatinus HN, Johnson MA, Wang HE, Hoareau GL, Youngquist ST: Early intramuscular adrenaline administration is associated with improved survival from out-of-hospital cardiac arrest. Resuscitation. 2024;August;201:110266.

2. Perkins GD, Ji C, Deakin CD, Quinn T, Nolan JP, Scomparin C, Regan S, Long J, Slowther A, Pocock H, et al.: A Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest. N Engl J Med. 2018;August 23;379(8):711–21.

3. Okubo M, Komukai S, Callaway CW, Izawa J: Association of Timing of Epinephrine Administration With Outcomes in Adults With Out-of-Hospital Cardiac Arrest. JAMA Netw Open. 2021;August 10;4(8):e2120176.

4. Hubble MW, Tyson C: Impact of Early Vasopressor Administration on Neurological Outcomes after Prolonged Out-of-Hospital Cardiac Arrest. Prehosp Disaster Med. 2017;June;32(3):297–304.

5.  Pugh AE, Stoecklein HH, Tonna JE, Hoareau GL, Johnson MA, Youngquist ST: Intramuscular adrenaline for out-of-hospital cardiac arrest is associated with faster drug delivery: A feasibility study. Resuscitation Plus. 2021;September;7:100142.

FAST25 | May 19-21, 2025 | Lexington, KY

🔥 FAST25 is back—bigger, bolder, and hotter than ever! 🔥

This isn’t just another conference—a high-energy, immersive experience for pre-hospital and critical care transport pros. Expert-led sessions, hands-on workshops, and unfiltered discussions will take your practice to the next level.

🚀 New for 2025: The Creator Festival – Featuring “Burnt Ones,” a spicy take on Hot Ones, where top EMS creators tackle scorching hot wings while answering the most challenging questions in the industry. Expect live demos, interactive exhibits, and big-name influencers sharing their insight in a way you won’t find anywhere else.

Plus, a killer vendor experience, special guests, catered lunches, and after-hours events that make networking effortless and enjoyable. FAST25 is where it all happens.

📍 Central Bank Center | Lexington, KY
🏨 Hilton Lexington/Downtown (special rates available!)
🎟️ Tickets are limited—grab yours now: flightbridgeed.com/fast25