In this episode of the Storey StrengthCast, Shane Storey breaks down one of the hottest topics in the fitness and health world right now: peptides.

From GLP-1 medications like semaglutide (Ozempic) and tirzepatide (Mounjaro) to newer compounds such as retatrutide, Shane explores what these substances are, how they work, and why they’ve become so popular in both the media and the fitness industry.But this isn’t just a hype-driven breakdown. Shane digs into the evidence, dosing, safety, and ethics behind these compounds, explaining where they may genuinely help and where the conversation gets murky. He also looks at how peptides may affect natural bodybuilding, coaching practices, and the long-term sustainability of fat loss when habits and structure aren’t in place.

Key Topics Covered

• What peptides are and how they differ from proteins
• The role of GLP-1 receptor agonists in appetite regulation and weight loss
• The differences between semaglutide, tirzepatide, and retatrutide
• Why research-backed dosing matters
• The risks of using BPC-157, TB-500, SLU-PP-332, and other grey-market compounds
• How peptide marketing is shaped by social media hype
• The impact of weight-loss drugs on natural bodybuilding
• Why coaching still matters even when drugs reduce appetite
• The danger of relying on “quick fixes” without building habits
• Concerns about product quality, contamination, and misleading labels in unregulated markets

Q&A form:

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00:00 Peptides Hype And Concerns

00:50 What Peptides Actually Are

02:29 GLP Drugs Explained

04:26 Trials Dosing And Safety

06:34 Using GLPs The Right Way

07:34 Bodybuilding Prep Applications

11:51 Lifestyle Risks And Crutch

14:01 Habits To Pair With GLPs

15:56 Coaching Trust And Disclosure

20:44 Training Still Matters Most

25:17 Natural Bodybuilding And Testing

28:52 WADA Bans And Gray Areas

30:46 Rodent Data And SLU-PP332

35:05 BPC-157 Evidence And Placebo

41:05 Gray Market Quality Risks

46:19 Wrap Up And Next Steps

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