SetSet with April Pride

Ep. 94 | Psilocybin Harm Reduction with PsiloSafe


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94. Can We Trust Psychedelics? Inside PsiloSafe’s Mission to Keep You Safe

How do we reduce harm as psychedelics move from sacred circles to Shopify carts? In this eye-opening episode, April Pride is joined by Joe Robinson, founder of PsiloSafe—a self-regulating initiative working to bring transparency, education, and safety standards to unregulated psilocybin products. They discuss the rise in psilocybin contamination, synthetic analogs like 4-ACO-DMT, and the urgent need for safe sourcing and consumer screening tools. Joe draws from his two decades in the medical industry and current role in branding psychedelic products to explain how PsiloSafe is raising the bar for safety—without waiting on the FDA. If you’ve ever wondered whether your mushroom chocolate is actually psilocybin, or how to avoid risk as a consumer or practitioner, this one’s for you.

🔵 Key Takeaways

-Not all psychedelics are what they claim. Products labeled as “psilocybin” often contain synthetic alternatives like 4-ACO-DMT—which may pose more risk.

-Testing matters. PsiloSafe is creating standards for clean psilocybin products, even in unregulated markets, to prevent contamination and overdose.

-Joe’s medical background informs his mission. With 20+ years in healthcare and pharma, Joe applies clinical thinking to psychedelic product safety and education.

-Consumer screening is a game-changer. PsiloSafe is piloting tools to help users self-assess whether psychedelics are safe for them—based on health history.

-Long-term use isn’t risk-free. April flags emerging evidence of cardiovascular concerns from repeated psilocybin use, urging listeners to stay curious—and cautious.

Learn more about this episode, including guests and resources on substack:https://aprilpride.substack.com/p/psilocybin-harm-reduction-with-psilosafe

Hosted by April Pride

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SetSet with April PrideBy April Pride

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