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Episode 12: Thalidomide
Do you know what the worst manmade medical disaster in history was? It wasn't all that long ago! Venus and Kayla discuss the poison that caused thousands of severe birth defects worldwide and has still yet to be fully addressed.
1. Ballentine, C. Sulfanilamide Disaster FDA Consumer [Online], 1981. (accessed 12 Aug 2021).
2. Ruthenberg, K., Chapter 6: About the Futile Dream of an Entirely Riskless and Fully Effective Remedy: Thalidomide. In Ethics of Chemistry, Schummer, J.; Børsen, T., Eds. Aalborg University: Denmark, 2021; pp 141-167.
3. Rägo, L.; Santoso, B., Drug Regulation: History, Present and Future. In Drug Benefits and Risks: International Textbook of Clinical Pharmacology, revised 2nd ed., World Health Organization: who.int, 2008; pp 65-77.
4. Thomas, K. The Unseen Survivors of Thalidomide Want to be Heard The New York Times [Online], 2020. https://www.nytimes.com/2020/03/23/health/thalidomide-survivors-usa.html (accessed 10 Aug 2021).
5. Kim, J. H.; Scialli, A. R., Thalidomide: The tragedy of birth defects and the effective treatment of disease. Tox Sci 2011, 122 (1), 1-6.
6. Thalidomide. https://www.sciencemuseum.org.uk/objects-and-stories/medicine/thalidomide (accessed 24 Mar 2021).
7. McNeill, L. The Woman Who Stood Between America and a Generation of 'Thalidomide Babies' Smithsonian Magazine [Online], 2017. https://www.smithsonianmag.com/science-nature/woman-who-stood-between-america-and-epidemic-birth-defects-180963165/ (accessed 24 Mar 2021).
8. Vargesson, N., Thalidomide-induced teratogenesis: History and mechanisms. Birth Defects Research Part C: Embryo Today 2015, 105 (2), 140-156.
9. Bren, L., The Road to the Biotech Revolution - Highlights of 100 Years of Biologics Regulation. FDA Consumer 2006.
10. West, J. G. The accidental poison that founded the modern FDA The Atlantic [Online], 2018. (accessed 2018).
11. Thalomid® (thalidomide) capsules - AU Product Information. In Australian Government Department of Health, Therapeutic Goods Administration: ebs.tga.gov.au, 2020; p 25.
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By Kayla Woods and Venus de Neko
5
1818 ratings
Do you know what the worst manmade medical disaster in history was? It wasn't all that long ago! Venus and Kayla discuss the poison that caused thousands of severe birth defects worldwide and has still yet to be fully addressed.
1. Ballentine, C. Sulfanilamide Disaster FDA Consumer [Online], 1981. (accessed 12 Aug 2021).
2. Ruthenberg, K., Chapter 6: About the Futile Dream of an Entirely Riskless and Fully Effective Remedy: Thalidomide. In Ethics of Chemistry, Schummer, J.; Børsen, T., Eds. Aalborg University: Denmark, 2021; pp 141-167.
3. Rägo, L.; Santoso, B., Drug Regulation: History, Present and Future. In Drug Benefits and Risks: International Textbook of Clinical Pharmacology, revised 2nd ed., World Health Organization: who.int, 2008; pp 65-77.
4. Thomas, K. The Unseen Survivors of Thalidomide Want to be Heard The New York Times [Online], 2020. https://www.nytimes.com/2020/03/23/health/thalidomide-survivors-usa.html (accessed 10 Aug 2021).
5. Kim, J. H.; Scialli, A. R., Thalidomide: The tragedy of birth defects and the effective treatment of disease. Tox Sci 2011, 122 (1), 1-6.
6. Thalidomide. https://www.sciencemuseum.org.uk/objects-and-stories/medicine/thalidomide (accessed 24 Mar 2021).
7. McNeill, L. The Woman Who Stood Between America and a Generation of 'Thalidomide Babies' Smithsonian Magazine [Online], 2017. https://www.smithsonianmag.com/science-nature/woman-who-stood-between-america-and-epidemic-birth-defects-180963165/ (accessed 24 Mar 2021).
8. Vargesson, N., Thalidomide-induced teratogenesis: History and mechanisms. Birth Defects Research Part C: Embryo Today 2015, 105 (2), 140-156.
9. Bren, L., The Road to the Biotech Revolution - Highlights of 100 Years of Biologics Regulation. FDA Consumer 2006.
10. West, J. G. The accidental poison that founded the modern FDA The Atlantic [Online], 2018. (accessed 2018).
11. Thalomid® (thalidomide) capsules - AU Product Information. In Australian Government Department of Health, Therapeutic Goods Administration: ebs.tga.gov.au, 2020; p 25.