First, Céline Gounder of NYU’s Grossman School of Medicine joins us to discuss the issue of breakthrough coronavirus infections and whether the U.S. was too quick to unmask. Then, STAT's Rachel Cohrs calls in to share the curious case of the moderate Democrat who made thousands of dollars in pharma donations within two days of attacking a drug pricing bill. We also discuss Biogen's latest defense of Aduhelm, the debate over Johnson & Johnson's Covid-19 vaccine, and the latest movie casting Big Pharma as a villain.