For the first time in history, scientists have completed the construction of a fully synthetic eukaryotic genome, marking a monumental leap in synthetic biology. After more than a decade of research, an international team, including scientists from Macquarie University, has successfully synthesized the final chromosome of baker’s yeast (Saccharomyces cerevisiae), opening new possibilities for engineered life forms and biotechnological advancements. In this episode of Youthquake, host Can Sinan is joined by returning guest Tugra to unravel how scientists built the world's first synthetic yeast genome, the role of CRISPR D-BUGS gene-editing in debugging genetic errors, and what this means for the future of medicine, agriculture, and sustainability. Could this discovery lead to synthetic plants and even artificial human genomes? What ethical concerns arise as we rewrite the code of life? Join us as we explore this landmark moment in genetic engineering, featuring insights from leading synthetic biologists and researchers.