Cell engineering is entering a new era, where vibrations, rather than chemicals, can be used to shape how cells grow, move, and function. Scientists are now harnessing the power of mechanotransduction—the process by which cells convert mechanical forces into biochemical signals—to develop innovative therapies for bone regeneration, wound healing, and even neurodegenerative diseases. In this episode of Youthquake, host Can Sinan sits down with returning guest Tugra to break down how precisely controlled vibrations can influence cellular behavior without relying on costly or imprecise chemical treatments. From stimulating stem cells to grow into bone tissue to potentially reversing muscle loss in aging populations, this technology has the potential to revolutionize medicine. But how close are we to real-world applications? What challenges remain in making vibrational therapies mainstream? Join us as we explore the science, breakthroughs, and future possibilities of vibration-based cell engineering, with insights from leading research institutions shaping this cutting-edge field.

Today on Youthquake, host Can Sinan welcomes returning guest Tugra to analyze the recent DC plane crash and explore the possible technical failures that led to the tragedy. With aviation accidents, the smallest miscalculation, mechanical failure, or human error can have catastrophic consequences. In this episode, they break down the key factors that could have contributed to the incident, including pilot error, air traffic miscommunication, potential engine failures, and systemic lapses in aviation safety protocols. How do investigators determine the root cause of a crash? What role do black box data, aircraft maintenance records, and air traffic control logs play in reconstructing the final moments of the flight? Can and Tugra will also discuss previous aviation disasters and how lessons from past failures have shaped modern flight safety regulations and technology. Could this crash have been prevented? What improvements need to be made to ensure safer skies? Join us as we unpack the technical, regulatory, and human factors behind the DC plane crash and explore what can be done to prevent such tragedies in the future.

On January 30, 2025, American Eagle Flight 5342 collided mid-air with a U.S. Army UH-60 Black Hawk helicopter over the Potomac River near Washington, D.C., during the plane's final approach to Reagan National Airport. Tragically, all 67 people on board both aircraft lost their lives. The victims included Olympic figure skaters, their coaches, and military personnel. Investigations are ongoing to determine the exact cause, with air traffic control and communication errors being central areas of focus.

For the first time in history, scientists have completed the construction of a fully synthetic eukaryotic genome, marking a monumental leap in synthetic biology. After more than a decade of research, an international team, including scientists from Macquarie University, has successfully synthesized the final chromosome of baker’s yeast (Saccharomyces cerevisiae), opening new possibilities for engineered life forms and biotechnological advancements. In this episode of Youthquake, host Can Sinan is joined by returning guest Tugra to unravel how scientists built the world's first synthetic yeast genome, the role of CRISPR D-BUGS gene-editing in debugging genetic errors, and what this means for the future of medicine, agriculture, and sustainability. Could this discovery lead to synthetic plants and even artificial human genomes? What ethical concerns arise as we rewrite the code of life? Join us as we explore this landmark moment in genetic engineering, featuring insights from leading synthetic biologists and researchers.

A groundbreaking discovery has reshaped our understanding of evolution—scientists have identified the first nitrogen-fixing organelle, the nitroplast, inside the marine alga Braarudosphaera bigelowii. This finding challenges long-held beliefs about nitrogen fixation and provides a missing link in the evolution of eukaryotic cells. In this episode of Youthquake, host Can Sinan is joined by guest Tugra to explore the origins of the nitroplast, how it evolved from an ancient symbiotic bacterium, and why it matters for both evolutionary biology and sustainability. Join us as we unpack the science, the implications, and the surprising twists in evolution with insights from leading microbiologists and evolutionary experts.

Early 2025, devastating fires started in California, leaving thousands displaced, homes destroyed, and lives lost. Driven by one of the strongest Santa Ana wind events in over a decade, with gusts reaching nearly 100 mph, the fires spread at an unprecedented pace, overwhelming emergency responders and forcing tens of thousands to flee. In this episode, host Can Sinan is joined by returning guest Erim to break down the destruction, the human and environmental toll, and the failures in disaster response that have left many without aid But the destruction didn’t stop with the flames. Toxic air pollution, habitat loss, and water shortages have worsened the crisis, exposing the harsh reality of climate change’s role in intensifying natural disasters.

San Francisco officials aren’t shedding tears over Elon Musk’s X leaving the city. The company, which has faced criticism for various reasons, has decided to relocate, prompting local leaders to express relief. Some officials have been vocal about their dissatisfaction with Musk’s business practices and impact on the city, viewing the move as a positive change. The departure reflects ongoing tensions between the tech industry and San Francisco’s governance, highlighting the challenges of balancing innovation with community impact. Let’s discuss it!

Artificial Intelligence (A.I.) is vital for businesses, offering enhanced efficiency, improved customer experience, and cost reduction. By automating routine tasks, A.I. frees up time for employees to focus on strategic activities, boosting productivity. It enables personalized customer interactions, leading to higher satisfaction and loyalty, while providing 24/7 support through chatbots. A.I. also drives innovation by analyzing data to predict trends, helping businesses stay competitive and develop new products. It reduces costs by optimizing operations and minimizing errors. Additionally, A.I. offers scalability, allowing businesses to grow without proportional increases in resources, and aids in better risk management through fraud detection and compliance monitoring. Ultimately, A.I. empowers businesses to make data-driven decisions, enhance their marketing strategies, and improve overall efficiency, making it a crucial tool in today’s competitive landscape. Let’s discuss it!

In this Youthquake episode, host Can Sinan and guest Ali dive into President-elect Donald Trump’s energy production policy, focusing on his "drill, baby, drill" approach to boosting domestic oil and gas exploration. They discuss potential benefits, including energy independence, job creation, and economic growth, while addressing criticisms from climate advocates about increased emissions and missed opportunities for renewable energy investment. Featuring insights from experts like Kevin Hassett, Michael Mann, and Dan Yergin, the episode explores how these policies could shape the U.S. economy, environmental efforts, and global energy markets. Join us for a balanced analysis of this polarizing topic!

In this Youthquake episode, host Can Sinan and guest Ali explore President-elect Donald Trump’s deregulation agenda, aimed at fostering economic growth by reducing government constraints on industries like energy, finance, and healthcare. They examine the potential benefits, including lower costs for businesses, increased competitiveness, and job creation, alongside criticisms about environmental risks, financial instability, and weakened worker protections. Featuring insights from experts like Larry Kudlow and Joseph Stiglitz, the episode delves into how deregulation could reshape the U.S. economy, the environment, and global markets. Tune in for a thought-provoking discussion on one of Trump’s most ambitious economic policies!