Dr. Deb Muth 00:00:09
Hi there, how are you?

Bob Miller 00:00:10
Excellent! Pedaling as fast as humanly possible, but doing okay.

Dr. Deb Muth 00:00:14
Good, good. Well, I’m looking forward to our conversation today. This should be amazing.

Bob Miller 00:00:20
Yeah, it should be a lot of fun.

Dr. Deb Muth 00:00:22
Yeah, anything that’s off-limits for you in, our conversation?

Bob Miller 00:00:28
No.

Dr. Deb Muth 00:00:29
Okay, anything you want me to make sure we cover for you?

Bob Miller 00:00:33
Well, I mean, is it okay if we put a little plug-in for our software?

Dr. Deb Muth 00:00:35
Absolutely.

Bob Miller 00:00:36
Yeah.

Dr. Deb Muth 00:00:37
Absolutely.

Bob Miller 00:00:36
Yeah.

Dr. Deb Muth 00:00:37
Absolutely.

Bob Miller 00:00:38
Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and…

Dr. Deb Muth 00:00:43
Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share.

Bob Miller 00:00:48
Okay.

Dr. Deb Muth 00:00:49
And yeah, feel free to plug your software wherever you want to.

Bob Miller 00:00:53
Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down.

Dr. Deb Muth 00:01:01
No worries.

Bob Miller 00:01:16
And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like?

Dr. Deb Muth 00:01:18
Dr. Deb is great, or Deb, either way, I’m pretty informal, so…

Bob Miller 00:01:22
Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously.

Dr. Deb Muth 00:01:33
Right? I agree.

Bob Miller 00:01:35
When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop.

Dr. Deb Muth 00:01:41
Yep, that’s how I am, too. Just call me Deb, it’s good.

Dr. Deb Muth 00:01:44
They feel a little awkward with that, you know? They’re not used to that, but…

Bob Miller 00:01:48
Alright. And you’re a naturopath, medical doctor.

Dr. Deb Muth 00:01:52
A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right?

Bob Miller 00:01:58
Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR.

Dr. Deb Muth 00:02:23
Oh, nice!

Bob Miller 00:02:24
And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged.

Dr. Deb Muth 00:02:32
Love that.

Bob Miller 00:02:34
I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry.

Dr. Deb Muth 00:02:44
Yeah.

Bob Miller 00:02:45
And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics.

Dr. Deb Muth 00:02:54
Which is so much better.

Bob Miller 00:02:56
Yeah. Are you familiar with what we do here, or…

Dr. Deb Muth 00:02:58
A little bit, a little bit. So, it’ll be new to me, too, so I’m excited.

Bob Miller 00:03:03
And how much time do we have?

Dr. Deb Muth 00:03:04
We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere?

Bob Miller 00:03:10
No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay.

Dr. Deb Muth 00:03:16
Perfect. Alright.

Bob Miller 00:03:18
It’s like we’re getting started early as well, so…

Dr. Deb Muth 00:03:19
Yeah, we’re getting started a little bit early, so that’s good.

Bob Miller 00:03:22
Yeah, I just got my office cleaned up, so…

Dr. Deb Muth 00:03:23
Okay, good. All right, are you all set to get started?

Bob Miller 00:03:28
I’m good to go, my friend.

Dr. Deb Muth 00:03:29
I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go.

Bob Miller 00:03:39
Okay, you got it.

Dr. Deb Muth 00:03:40
Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know.
Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey.

Bob Miller 00:05:04
Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis.

Bob Miller 00:05:15
And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun.

Dr. Deb Muth 00:05:27
Not an option I would want.

Bob Miller 00:05:29
So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today.

Dr. Deb Muth 00:05:58
I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it?

Bob Miller 00:06:10
Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits
Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today.

Dr. Deb Muth 00:07:37
This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that?

Bob Miller 00:07:51
Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from.
Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron.
And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger.

Dr. Deb Muth 00:09:14
Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics?

Bob Miller 00:09:53
Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is.

Bob Miller 00:10:03
Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing.

Dr. Deb Muth 00:10:15
I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well.

Bob Miller 00:10:25
Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works.
But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains.

Dr. Deb Muth 00:12:29
This is true.

Bob Miller 00:12:32
So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact.

Bob Miller 00:13:40
And therein lies the problem. When they overreact, we have a problem.

Bob Miller 00:13:46
So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control.

Dr. Deb Muth 00:14:06
Right.

Bob Miller 00:14:07
And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change.

Bob Miller 00:14:28
The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so…

Dr. Deb Muth 00:15:31
Yeah, for being… having a little too much fun, right?

Bob Miller 00:15:35
So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents.

Dr. Deb Muth 00:15:50
In identical twins, do they have the exact same identical makeup?

Bob Miller 00:15:54
Yep,

Dr. Deb Muth 00:15:56
But not in fraternal twins, correct?

Bob Miller 00:15:59
No, no, those could be different, Jeff.

Dr. Deb Muth 00:16:00
It could be different because they have different sacs, they’re not sharing that same genetic makeup.

Bob Miller 00:16:04
Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another.

Dr. Deb Muth 00:16:13
So…

Bob Miller 00:16:14
Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two.

Dr. Deb Muth 00:16:41
Interesting.

Bob Miller 00:16:42
So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two.

Dr. Deb Muth 00:17:19
too.

Bob Miller 00:17:20
Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen.

Dr. Deb Muth 00:17:27
Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day?

Bob Miller 00:17:47
Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made.

Dr. Deb Muth 00:17:55
Okay. And then that’s… that’s the hand you’re dealt.

Bob Miller 00:17:58
Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness.

Dr. Deb Muth 00:18:09
That is so very true.

Bob Miller 00:18:11
Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope.

Dr. Deb Muth 00:18:18
Oh, – –

Bob Miller 00:18:19
You gotta play the hands you’re dealt, so…

Dr. Deb Muth 00:18:21
That’s right.

Bob Miller 00:18:22
You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint.

Dr. Deb Muth 00:18:30
It’s good and bad, right? It’s the one test you only have to do once in your lifetime.

Bob Miller 00:18:34
No, unless, you know, like, our.

Dr. Deb Muth 00:18:36
All the time.

Bob Miller 00:18:37
Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps.

Dr. Deb Muth 00:18:46
Wow, that’s a lot.

Bob Miller 00:18:47
That’s not all of them.

Dr. Deb Muth 00:18:49
Right.

Bob Miller 00:18:50
So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat.
But whatever we measured is gonna stay the same.

Dr. Deb Muth 00:19:03
That’s a lot of SNPs to look at.

Bob Miller 00:19:05
Keeps us busy.

Dr. Deb Muth 00:19:06
But there’s still, but there’s still SNPs that we.

Bob Miller 00:19:09
That we’d like to have that we don’t have, so…

Bob Miller 00:19:11
We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so…

Dr. Deb Muth 00:19:29
Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions?

Bob Miller 00:19:43
Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense?

Bob Miller 00:19:48
Alright, so… let’s see if I… let me just press the share…

Dr. Deb Muth 00:19:52
Yep, you should just be able to press share.

Bob Miller 00:19:54
And… number 2. Okay. Are we seeing the screen there?

Bob Miller 00:20:01
Okay.

Dr. Deb Muth 00:20:02
So, this is a map that we made.

Bob Miller 00:20:05
And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them.
Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy.
Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage.

Dr. Deb Muth 00:22:31
Hmm.

Bob Miller 00:22:32
But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD.

Dr. Deb Muth 00:22:48
Yep.

Bob Miller 00:22:49
Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954.

Dr. Deb Muth 00:23:01
And it was a different world back then.

Bob Miller 00:23:05
These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID.

Dr. Deb Muth 00:23:26
Yeah.

Bob Miller 00:23:27
Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation.

Dr. Deb Muth 00:23:40
Go.

Bob Miller 00:23:41
Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t…

Dr. Deb Muth 00:24:13
I have.

Bob Miller 00:24:14
I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals.

Dr. Deb Muth 00:24:26
You know, if we have a…

Bob Miller 00:24:27
You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive?

Dr. Deb Muth 00:25:16
Oh yeah, we have a whole bunch of them.

Bob Miller 00:25:18
Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive.

Dr. Deb Muth 00:26:31
Hmm.

Bob Miller 00:26:32
Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking?
We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem.
NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop.
So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay?

Bob Miller 00:31:22
Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense?

Dr. Deb Muth 00:32:24
Yeah, makes perfect sense.

Bob Miller 00:32:25
Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD.

Dr. Deb Muth 00:32:31
Right.

Bob Miller 00:32:32
And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that.

Dr. Deb Muth 00:32:45
Hmm.

Bob Miller 00:32:46
what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide.
That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase.
If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb.

Dr. Deb Muth 00:37:07
There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there?

Bob Miller 00:37:22
Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is…

Dr. Deb Muth 00:37:59
And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs.

Dr. Deb Muth 00:38:04
And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct?

Bob Miller 00:38:13
Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion.

Dr. Deb Muth 00:38:30
Interesting.

Bob Miller 00:38:31
Yeah. So… it can be… I see why people use it, because it.

Bob Miller 00:38:36
pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here.

Dr. Deb Muth 00:39:40
Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen.

Dr. Deb Muth 00:39:58
Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins.

Bob Miller 00:40:12
Sure.

Dr. Deb Muth 00:40:14
Yeah, absolutely. Well, GPX4.

Bob Miller 00:40:18
is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione.

Dr. Deb Muth 00:40:30
Yeah.

Bob Miller 00:40:31
Well, guess who controls making a glutathione?

Dr. Deb Muth 00:40:34
Nerf 2.

Bob Miller 00:40:37
So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione.

Dr. Deb Muth 00:40:51
Right.

Bob Miller 00:40:52
And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well.

Dr. Deb Muth 00:41:43
Yeah.

Bob Miller 00:41:44
You need it, but you need to recycle it.

Dr. Deb Muth 00:41:46
Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece.

Dr. Deb Muth 00:42:04
understanding genetics.

Bob Miller 00:42:06
Yeah, to be honest, it drives me nuts.

Dr. Deb Muth 00:42:08
Me too.

Bob Miller 00:42:11
Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine.

Bob Miller 00:42:36
it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR.

Dr. Deb Muth 00:42:51
I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay.

Bob Miller 00:42:56
But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate.

Dr. Deb Muth 00:43:13
And they’re pushing it too hard.

Bob Miller 00:43:15
Yeah. So I can’t tell you how many people I’ve helped by saying, stop it.

Dr. Deb Muth 00:43:20
Yeah, take less of it.

Bob Miller 00:43:21
Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals.

Dr. Deb Muth 00:43:40
deals.

Bob Miller 00:43:41
NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy.

Dr. Deb Muth 00:44:29
And it’s kind of scary what’s happening to us.

Bob Miller 00:44:33
So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like…

Dr. Deb Muth 00:44:44
Excuse me.

Bob Miller 00:44:45
can’t you put your political differences aside to have Christmas together, you know?

Dr. Deb Muth 00:44:49
Right?

Bob Miller 00:44:50
become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry.

Dr. Deb Muth 00:45:05
Yeah.

Bob Miller 00:45:06
So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay.

Dr. Deb Muth 00:45:31
Nobody has enough of that anymore.

Bob Miller 00:45:33
Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron.

Dr. Deb Muth 00:46:09
Hmm.

Bob Miller 00:46:10
So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there?

Dr. Deb Muth 00:46:26
Yep.

Bob Miller 00:46:27
And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory.

Dr. Deb Muth 00:46:34
Hmm.

Bob Miller 00:46:36
Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does.

Dr. Deb Muth 00:47:33
Yeah.

Bob Miller 00:47:34
But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs.
Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess.

Dr. Deb Muth 00:49:58
thing.

Bob Miller 00:49:59
Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping.

Dr. Deb Muth 00:50:49
Hmm.

Bob Miller 00:50:50
Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know.

Dr. Deb Muth 00:51:00
Yup.

Bob Miller 00:51:01
your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more.

Dr. Deb Muth 00:51:28
I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep.

Bob Miller 00:51:31
We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar?

Dr. Deb Muth 00:52:25
That’s where COVID comes in, using ACE2.

Bob Miller 00:52:28
And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why.

Dr. Deb Muth 00:53:08
To the people.

Bob Miller 00:53:09
Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything.

Dr. Deb Muth
Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all.

Bob Miller 00:53:30
Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself.

Dr. Deb Muth 00:53:38
Keep creating more inflammation, more complications, nothing’s calming down.

Bob Miller 00:53:43
Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number?

Dr. Deb Muth 00:55:24
Yeah, I like mine below 7.

Bob Miller 00:55:26
Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah.

Dr. Deb Muth 00:56:27
Right.

Bob Miller 00:56:28
So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation.

Bob Miller 00:56:36
get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment.

Dr. Deb Muth 00:56:50
Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver.

Bob Miller 00:57:17
Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay?

Dr. Deb Muth 00:57:48
And as you said, there’s an MTR enzyme.

Bob Miller 00:57:51
that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater.

Dr. Deb Muth 00:59:07
It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level.

Bob Miller 00:59:36
Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well…

Bob Miller 00:59:56
Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all.

Bob Miller 01:00:07
things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling.

Bob Miller 01:00:28
Yep.

Dr. Deb Muth 01:00:29
Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough.

Bob Miller 01:00:44
Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay.

Dr. Deb Muth 01:00:53
Yeah.

Bob Miller 01:00:54
Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of…

Bob Miller 01:01:36
Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD.
And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember I said earlier the NOx enzyme? takes NADPH to make superoxide. So, if this guy’s upregulated, We’re not gonna have our NADPH, and we’re gonna make inflammation. Now, I’m going to show you the sirtuins a little bit later. But… The sirtuins do a lot of important jobs. SIRT3 helps an enzyme called superoxide dismutase neutralize the superoxide. the, the Cert II stops the guy who makes the gas Germans that… to damage the, The cell membranes. there’s an enzyme called PARP that does repair. All of those are NAD-dependent, so you would think, well, the more NAD I get. the better off I am. But remember I said earlier there’s an enzyme called CD38. And if we’re exposed to… Mycotoxins, lime, aluminum, too much EMF. High fructose corn syrup, lead, mercury, glyphosate, cigarette smoke, diesel exhaust, dioxins. herbicides. It’ll stimulate this CD38, Hang on to your head here, Dr. Debb. takes 100 molecules of NAD, to make one molecule of cyclic ADB ribose, And that’s gonna stimulate the NLRP3, and it’s starting to sound like Chinese now.

Dr. Deb Muth 01:04:19
That’s this guy right here that makes all that inflammation.

Bob Miller 01:04:24
So, that’s where, if you take NAD, Well, this is upregulated. You can make yourself worse. So, we, we do a test called U.S. Biotech. NAD, very valuable. It’ll measure the NAD… NAD pH. NADH. And if this guy’s high and this guy’s low. We may have to first work on getting this over, and look at the, there’s only one thing that’ll do that, Pawti Arco. called beta-letchome that will help the NQO1 bring this back. So, sometimes what we have to do is we have to Pull this guy over. Calm this guy down. I’ll only then start putting a little bit of… N-A-D-M. Now, the, one of the pathways that we’re, Really, really excited about. This is one of the new ones we’re looking at. And I think there’s gonna be a real game changer. Inside the cell membrane, there’s something called arachidenic acid. And it helps… it’s useful. Helps the skin, helps, you know, give strength to the cell membrane. But there’s an enzyme called… PLA2. And PLA2, when stimulated. We’ll pull arachidenic acid out of the cell membrane, and people are going to resonate with this. it stimulates the COX enzymes, COX-1 and COX-2, that makes prostaglandins, and I’m
like, well, I’ve never heard of that. But everybody knows Tylenol, Aspirin, Excedrin, Ibuprofen.
They inhibit these enzymes. And that’s why they’re pain-relieving. They might kill your liver and kidneys, but they’re pain-relieving. I’ve seen a couple people now that have kidney failure because of taking You know, for years, taking. NSAIDs. So, that’s where aspirin and all these guys work. They calm this guy down. But now we believe a better solution is, how about if we pull less arachidonic acid out of the cell membrane? So… What does that? Look at our players. And if Kappa B Interleukin-6.
Tumor necrosis factor. Same ones. They will stimulate this guy to pull arachidanic acid. Out of the cell membrane. Now, what’s interesting is what else does this? There’s something called an NMDA receptor. That will, again, stimulate that intracellular calcium. And there’s genes called GRIN. And you can see this person has a grin mutation that only occurs in 3.2%.
Of the population. And, I think there’s another grin up here. No, there’s no one there. The, but these grins will cause the NMDA receptor to be upregulated. And then that will stimulate the PLA2 enzyme to bring it out. Now, this is our most recent research. Dopamine. When it gets caught in the dopamine receptor site, will stimulate PLA2. And you can see this person had two homozygous here. And then if you don’t break down dopamine by… COMT, or… MAOA, It stimulates this. Now, on the other hand, we have a braking system. The body makes something called… DHA. And the DHA will calm down the PLA too. But we can have genetic mutations that we don’t take our fish oils, and turn them into DHA. And then many people know that when they, when they have inflammation, the doctor will give them prednisone or cortisol So, your body makes Cortisol. But here again, we can have genetic issues. That we don’t make enough cortisol. And this, this example is an individual who had severe mast cell activation syndrome.
So the, so there’s a lot that can go, that go wrong here, including, back to our M1 and our M2, These prostaglandins will eventually stimulate M1, Which then goes in a… Circle of… of inflammation. Now, last map that we’re going to show you, this is Nolan, but this is the highlights. the, this one’s designed how environmental factors will impact us. And here we have the, the M1 and the M2. Here’s M1, and this individual. The nerve, too, is weak. The mTOR is too strong. It stimulates those same players that we’ve talked about. It stimulates the INOS, It makes the peroxyn nitrite. And that stimulates the mast cells. Again, this was a person with mast cell activation syndrome. And as we spoke about, it spins around in a circle, And makes… More superoxide. And around we go in a circle. And then lastly, I’m sure you’ve seen, People that you gave them progesterone, and they were… felt better, and some people felt worse?

Bob Miller 01:10:01
Yeah. So, what happens is, progesterone Can go one of two ways. It can actually make more aldosterone that makes more inflammation. Or it can make the cortisol that breaks down the, the excess inflammation. It’s controlled by this enzyme called CYP17A1. And you can see this individual. Had a mutation that occurs in 1% of the population. And then we need the POR enzyme, to handle over NADPH. This one occurs in 1% of the population. So, in this example here. The, the progesterone was more likely going to make more inflammation rather than be anti inflammatory, getting the mast cell activation syndrome. So… Again, this does not diagnose disease. It’s not a treatment for disease, but it’s looking at Where there’s missing function. And then, where the function can be. Keyword. compensated for.

Dr. Deb Muth 01:11:13
Well, and knowing your genetics can help identify, too, like, what supplements are going to work best for you. Which supplements do you need lifelong, because these pathways are not open, and which ones… you know, a lot of people just load on supplements. I see it every day. People come in with. 50, 60 supplements that they’re taking, and they have no idea what’s working, what’s not, what’s making them feel worse. But having a genetic… Tests done like this can help us identify, like, what is it that you actually need to get your body back to where it should be, instead of guessing and just spending thousands of dollars a month on supplements.

Bob Miller 01:11:51
Yeah, I mean, I see people, it’s like, how in the world do you swallow that much?

Dr. Deb Muth 01:11:55
Yeah, I…

Dr. Deb Muth 01:11:56
I don’t know how they do it.

Bob Miller 01:11:58
And most of them are not doing well anyway.

Dr. Deb Muth 01:12:00
Yeah,

Bob Miller 01:12:01
Yeah. So, I mean, you start looking at it, oh, you’re taking this multiple vitamin with methylfolene in it. Then you’re taking this B complex with methylfolate in it. And it’s like, okay, no wonder you’re so anxious.

Dr. Deb Muth 01:12:14
Right.

Bob Miller 01:12:15
And then, one of my favorite pet peeves. Is that there’s this trend, if you have an inflamed gut, to take these powders with glutamine. And that might be… Okay, okay. But I see it backfiring more than helping. So the theory behind it is glutamine helps the growth of new cells, and that’s going to help your gut replenish its cells. But… Glutamine turns into glutamate. And if you’ve got this thing revved up. That glutamine’s gonna make more glutamate. that may then further stimulate NORP3. make more inflammation.

Dr. Deb Muth 01:12:54
Yeah.

Bob Miller 01:12:55
So, yeah, so people are, oh, my gut’s inflamed, and I was taking this glutamine powder, and it’s like… Now, I’m not saying that’s not helpful under some conditions. Under some conditions, it is. Right. But if you’ve got this upregulated, and you throw more glutamine in, You’re just gonna do that. Then the other one that, that happens sometimes. is people learn about, N-acetylcysteine. And, oh, N-acetylcysteine makes glutathione. Yale?

Dr. Deb Muth 01:13:26
And it’s great for long haul.

Bob Miller 01:13:28
Right. And it is. However, here’s the however. The cysteine comes in using this enzyme right here called SLC 17A11. Excess glutamate will shut it down. And then the cysteine, rather than doing these good things, Can actually be inflammatory. Oh, and you know what, I was amiss not talking about, G6PD. So, you’ll often see this In, people with Native American background, African background, Sicilian background. So… The G6PD mutation is one of the most common mutations in the world.

Dr. Deb Muth 01:14:12
And.

Bob Miller 01:14:14
What happens is, G6PD is critical to make your NADPH. Now, it’s interesting. It’s believed that this started in Africa, and I don’t honestly know the mechanism, I couldn’t explain it, but this G6PD mutation protected you from malaria. I don’t know how. But right now, having that G6PD mutation limits your body’s ability to make NADPH, And one of the trends right now is methylene blue.

Dr. Deb Muth 01:14:46
Yeah.

Bob Miller 01:14:47
And methylene blue is fine under some conditions. Because what it… what it does, it, let me see if I can find it real quickly. Methylene blue donates an electron at the end of the electron transport chain. So, you’d think, okay, I’m gonna take methylene blue. And I’m gonna feel better, I’m gonna get more energy. I mean, makes sense, because that’s… That’s what it does? Okay.

Dr. Deb Muth 01:15:10
Hmm.

Bob Miller 01:15:12
But if you’ve got G6PD, It’s actually contraindicated, and can make things worse.

Dr. Deb Muth 01:15:19
things worse. So here’s the electron transport chain.

Bob Miller 01:15:23
And here’s where those electrons bebop on down through here. Well, methylene blue just dumps an electron down here, so you make more energy. But I don’t know… I don’t think we fully understand the mechanism, but what I’m wondering is, and this is just a hypothesis, not a statement. If these electrons then don’t fly off and make superoxide.

Dr. Deb Muth 01:15:43
Hmm.

Bob Miller 01:15:44
Don’t know. That damages the red blood cells, and if you don’t have G6PD, it’s contraindicated. So, I’m not against methylene blue, but you should know if you got G6PD first.

Bob Miller 01:15:54
Particularly if you’ve… do you think there’s any Native American, African, Sicilian background.

Dr. Deb Muth 01:16:01
There’s a lot of people just buying Methylene Blue over the counter at a lot of different supplement companies and starting to take it and having issues. For sure.

Bob Miller 01:16:11
Oh, yeah, yeah. Now, what’s interesting… is on. You know, for a lot of men, erectile function is a serious issue. Not only erectile function, but from a standpoint of, blood flow. So, what’s fascinating here… Is that methylene blue? Has an interesting effect. the, we get something called, GTP that goes through this enzyme and does vasodilation. So, if anybody’s familiar with Viagra and Cialis, They inhibit the PD5 enzyme, That inhibits this. So you take Viagra Cialis, it inhibits the guy who inhibits this, Blood flow’s improved. However, methylene blue inhibits, just like PDE5.

Dr. Deb Muth 01:17:05
Hmm.

Bob Miller 01:17:06
So, methylene blue… Potentially, let’s use that word, Could impact the vasodilation.

Dr. Deb Muth 01:17:14
Sure.

Bob Miller 01:17:16
So, yeah, we’ve got to be real careful that we just don’t, take things willy-nilly and too much Yeah. Next up, huh? So I think those are the, the highlights that I wanted to, to show.

Dr. Deb Muth 01:17:29
This is your software system that you’ve created to, look at genetics?

Bob Miller 01:17:35
Oh, yeah, yeah. Yeah, what I did, about 14 years ago. I started using 23andMe, and I made a spreadsheet. And I loaded it up. put the information in, and then doctors learned about it, and they said, well, we want to do this too, so for a period of time, I was upgrading the spreadsheet, sending it to them, it’s like, well, this isn’t working too well. So I created my own software. And then, many years ago, 23andMe went to their version 5, And they dumped about… 40% of the enzymes that we were looking at. So I was like, yeah, okay. Do I want to do this or not? So I bit the bullet, and I worked with Thermo Fisher to develop my own chip.

Bob Miller 01:18:16
So, we have our own genetic test. And this software’s now taken me Close to 13 years and $7.5 million in programming costs.

Dr. Deb Muth 01:18:26
Wow.

Bob Miller 01:18:27
Yup. And but then I… I mean this humbly, but the feedback I’m getting from practitioners is, like.
There’s nothing that has this level of detail. Yeah.

Dr. Deb Muth 01:18:45
I mean, just looking at this from a person that looks at genetics, there’s nothing like this that I’ve seen that goes into this kind of detail that can find all the different spots, like, your software is doing right now.

Bob Miller 01:18:51
Yeah, it’s not for the faint of heart. To use this, you honestly have to study a little bit.

Bob Miller 01:18:57
Now, we’re working on that. One of the feedbacks we get from doctors is like, Bob, this is incredible, this is the future. I know this could be helpful, but I don’t have the time or willingness to study. So… What we’re doing now, and this is gonna… this is what’s really… Becoming difficult, but we’re making, We’re making what we call executive reports. So we’re trying to make it as easy as possible.

Dr. Deb Muth 01:19:24
Yeah.

Bob Miller 01:19:25
So, we’re making executive reports. That, if you don’t want to look at a map, because some people love the maps. Other people glaze over, they’re like, what?

Dr. Deb Muth 01:19:35
It’s too much, yeah, it’s a little overwhelming for them, for sure.

Bob Miller 01:19:39
Yeah. So, this is going to take a little while to load, but we make executive reports That, oh, this is the Executive Pyramid report, I got the wrong one. Okay. So the, no wonder it was taking so long. So will, oh, shoot, try to get out of here. But anyway, it’s making an executive report that walks you through each step and tells you where there’s weakness. So yeah, here we go. So we’re gonna look at the, The reports, we’re gonna look at the executive reports, there we go. So, for example, here we have one on sirtuins and NAD. It shouldn’t take too long. So… When it does, it tells you what sirtuins do. Then it shows you a little diagram. And then it’ll tell you what Cert2 does. And it says, in this person, there’s no genetic variance, it actually tells you that
CERT3, it points out the ones you have. And then, then it summarizes, and then it gives you potential interventions. So this is only for the doctors, but it’ll tell you there’s a product called Cert Cofactors that we made. And then we give the doctor the ability to actually make a, a custom Formula, if they want, through personalized nutrients, if they want to make it custom. The advantage to that is, when people get several supplements, you can have crossover of the ingredients, and you get too much.

Dr. Deb Muth 01:21:02
Right.

Bob Miller 01:21:03
So… so for the doctor, he said, you know what, I don’t want to look at maps, oh my god, that’s too complicated. we have these reports. Now, we’re in the early stages of this, we’re just in the discussion. But we also… what we want to do is we want to use AI that we program ourselves, not ChatGTP or anything else.

Bob Miller 01:21:21
We want to get our own… prior… our own proprietary AI.
That we program with our own language, so it doesn’t pull from anywhere else. And it’s gonna give you a report that says, you know, this one might be the most important one.
That’s probably a year out in development.

Dr. Deb Muth 01:21:36
Yeah.

Bob Miller 01:21:37
And that’s probably gonna cost a couple hundred thousand dollars.

Dr. Deb Muth 01:21:40
Yep.

Bob Miller 01:21:41
At best. But that’s the level of granularity, because we need to, We need to make it simpler. I mean, I live and breathe this stuff, this is all I do.

Dr. Deb Muth 01:21:49
Yeah. You know, I do it 9 to 11 hours a day, 6 days a week, so I know this stuff like the back of my hand.

Bob Miller 01:21:54
But for the doctor who doesn’t do it, they look at this and they… they… they glaze over.

Dr. Deb Muth 01:21:59
Absolutely. So if somebody’s listening to us and they want to use your software, how do they… how do they do that? How do they get in touch with you?

Bob Miller 01:22:09
Aaron, I’m gonna put up a slide here.

Dr. Deb Muth 01:22:11
Check.

Bob Miller 01:22:12
Let me find the slide… Here we go. So, it’s called Functional Genomic analysis. Functionalgenomicanalysis.com. And just go there, and you can sign up for a free trial. And then we have 2 support people that help you with it.

Bob Miller 01:22:35
And for somebody who wants to learn the basics, we also have a certification course that walks you through. And then, this is our research. This is the software, functional genomic Analysis, cloud-based software. This is the name of the test, your genomic resource. And then we have our own… we worked with Personalized Nutrients to come up with
supplements that support each of the functions, so… But if somebody wants to, you know… now this, please, if you’re just a consumer, don’t… don’t try to sign up, because it’s for doctors only. We’re going to ask you about your degree, and so, functionalgenomicanalysis.com. And then, they can sign up, talk to these folks.
Although I have a busy schedule, if, you know, if somebody would like to try to work with me, I still have, you know, I still have some openings now and again. Our clinic name is Tree of Life Health. Tolhealth.com, fill out the, the intake form. We’ll get you to get to the genetic test, then we’ll do a Zoom call just like this, and And look at your, look at your genome and find where the weak spots are, so…

Dr. Deb Muth 01:23:37
So, if you’re a consumer listening, you want to become a client of Dr. Bob’s. If you’re a practitioner, though, you want to go to Functionalgenomicsanalysis.com and sign up for an account.

Bob Miller 01:23:48
Right.

Dr. Deb Muth 01:23:49
Yeah, wonderful.

Bob Miller 01:23:50
And we do webinars every other Thursday evening where we geek out.

Dr. Deb Muth 01:23:54
That’s awesome, I love it.

Bob Miller 01:23:55
Yeah, are you on our webinars at all?

Dr. Deb Muth 01:23:56
I am not. I did not… I wasn’t aware of that.

Bob Miller 01:23:59
Well, I’ll have to get you the link, so…

Dr. Deb Muth 01:24:01
Yeah, please do, that’d be great.

Bob Miller 01:24:03
Yeah, last night we geeked out on, on the arachidic acid pathway.

Bob Miller 01:24:07
Thursdays, 8 to 9.30 p.m. Eastern Standard Time.

Dr. Deb Muth 01:24:11
Excellent. Well, thank you so much for sharing all this information with us, and it was… it was absolutely wonderful, and, you can tell it is truly your passion.

Bob Miller 01:24:24
It’s a lot of fun. But when you get to my age, you start thinking about your legacy. What did you do for the world? And so, it’s so heartwarming when I hear back from an autistic parent that, hey, my kid’s doing better. They’re not banging their head against the wall.

Bob Miller 01:24:39
Or somebody says, I can get out of bed now for the first time. Can’t think of anything more fun.

Dr. Deb Muth 01:24:45
Yeah, isn’t that the truth? Because then you can really make a difference with people.

Bob Miller 01:24:48
Yeah, so we’re hoping to be pioneers in this. And, so we’ve, we’ve made quite the mess with all these environmental factors.

Dr. Deb Muth 01:24:56
Yeah, we sure have.

Bob Miller 01:24:57
I often tell folks who have autistic kids, they’ll say, you know, if your kid had been born 70 years ago. They might be rambunctious. But that’d be about it.

Dr. Deb Muth 01:25:06
Yeah. Yeah, and unfortunately, because of all the things we’ve done to our environment, it’s different now. Yeah.

Bob Miller 01:25:15
Yeah, we really, really messed up. Well, it’s been a pleasure. This was a lot of fun.

Dr. Deb Muth 01:25:18
Thank you, you too. I appreciate your time.

Bob Miller 01:25:21
Okay, have a great rest of the day.

Dr. Deb Muth 01:25:22
Thank you, you too. Thank you, Dr. Bob, for sharing how functional genomics is changing the way we understand health and disease. If you’re listening and you’ve spent years chasing symptoms without relief, maybe this is the missing lens. Your genes may not be your enemy. They might be your roadmap. To learn more, visit Dr. Bob’s work at Tree of Life and explore genetic research and nutrigenetic Research Institute. And as always, remember, wellness isn’t about feeling better, it’s about uncovering the truth within your body so you can thrive. Until next time. I’m Dr. Deb, reminding you to take care of your body, mind, spirit, be well, and I’ll see you on the next episode.

The post Episode 268 – Mold+Lyme+Genetics: The Root Cause Most Doctors Miss first appeared on Let's Talk Wellness Now.