Lyme and PANDAS are a part of a growing set of issues known as Autoimmune Neuropsychiatric Disorders. Watching trends for the last 30 years, Dr Rubin recalls a time when Lyme was relatively infrequent and PANDAS was unheard of. Now we are seeing more and more kids with one or sometimes both of these challenges. And we are finding that once you develop either, you are prone to relapses.