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Episode 39: Serotonin
The happy chemical might not be the happy chemical after all, and it could actually kill you. Libby Zion probably didn't know this back in 1984, but her doctors should have.
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Albert, P. R., Benkelfat, C., & Descarries. (2012). The neurobiology of depression—revisiting the serotonin hypothesis. I. Cellular and molecular mechanisms. Phil Trans R Soc B, 367, 2378-2381.
Classen, D. C., Resar, R., Griffin, F., Federico, F., Frankel, T., Kimmel, N., Whittington, J. C., Frankel, A., Seger, A., & James, B. C. (2011). ‘Global Trigger Tool’ Shows That Adverse Events In Hospitals May Be Ten Times Greater Than Previously Measured. Health Affairs, 30(4), 581-589.
Cohen, S. (2014). The Lasting Legacy of a Case that was "Lost". Penn State Law Review. Retrieved 07 Mar 2023, from https://www.pennstatelawreview.org/penn-statim/the-lasting-legacy-of-a-case-that-was-lost/
Coppen, A. (1967). The Biochemistry of Affective Disorders. Brit J Psych, 113(504), 1237-1264.
Cowen, P. J., & Browning, M. (2015). What has serotonin to do with depression? World Psych, 14(2), 158-160.
Drugs Interaction Checker. https://www.webmd.com/interaction-checker/default.htm
Harmer, C. J., Duman, R. S., & Cowen, P. J. (2017). How do antidepressants work? New perspectives for refining future treatment approaches. Lancet Psych, 4(5), 409-418.
Healy, D. (2015). Serotonin and depression. BMJ, 350, h1771.
Hoffman, J. (1995, 02 May 1995). Judge Sets Aside Use of Cocaine as Part of Verdict in Zion Case. The New York Times.
Lerner, B. H. (2009). A Life-Changing Case for Doctors in Training. The New York Times. Retrieved 12 Mar 2023, from https://www.nytimes.com/2009/03/03/health/03zion.html
Nardil® (Phenelzine Sulfate Tablets, USP). In FDA (Ed.), FDA. accessdata.fda.gov.
Oura, P., & Sajantila, A. (2022). A recent two-fold increase in medical adverse event deaths among US inpatients. J Public Health Res, 11(4), 1-4.
Robins, N. (1995). The Girl Who Died Twice. Delacorte Press.
Serotonin. (2022). Cleveland Clinic. Retrieved 13 Mar 2023 from https://my.clevelandclinic.org/health/articles/22572-serotonin#:~:text=Serotonin%20is%20a%20chemical%20that,blood%20clotting%20and%20sexual%20desire.
Valkonen, V., Haatainen, K., Saano, S., & Tiihonen, M. (2023). Evaluation of Global trigger tool as a medication safety tool for adverse drug event detection—a cross‑sectional study in a tertiary hospital. Eur J Clin Pharma. https://doi.org/https://doi.org/10.1007/s00228-023-03469-5
Volpi-Abadie, J., Kaye, A. M., & Kaye, A. D. (2013). Serotonin Syndrome. Ochsner J, 13(4), 533-540.
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By Kayla Woods and Venus de Neko
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1818 ratings
The happy chemical might not be the happy chemical after all, and it could actually kill you. Libby Zion probably didn't know this back in 1984, but her doctors should have.
---
Albert, P. R., Benkelfat, C., & Descarries. (2012). The neurobiology of depression—revisiting the serotonin hypothesis. I. Cellular and molecular mechanisms. Phil Trans R Soc B, 367, 2378-2381.
Classen, D. C., Resar, R., Griffin, F., Federico, F., Frankel, T., Kimmel, N., Whittington, J. C., Frankel, A., Seger, A., & James, B. C. (2011). ‘Global Trigger Tool’ Shows That Adverse Events In Hospitals May Be Ten Times Greater Than Previously Measured. Health Affairs, 30(4), 581-589.
Cohen, S. (2014). The Lasting Legacy of a Case that was "Lost". Penn State Law Review. Retrieved 07 Mar 2023, from https://www.pennstatelawreview.org/penn-statim/the-lasting-legacy-of-a-case-that-was-lost/
Coppen, A. (1967). The Biochemistry of Affective Disorders. Brit J Psych, 113(504), 1237-1264.
Cowen, P. J., & Browning, M. (2015). What has serotonin to do with depression? World Psych, 14(2), 158-160.
Drugs Interaction Checker. https://www.webmd.com/interaction-checker/default.htm
Harmer, C. J., Duman, R. S., & Cowen, P. J. (2017). How do antidepressants work? New perspectives for refining future treatment approaches. Lancet Psych, 4(5), 409-418.
Healy, D. (2015). Serotonin and depression. BMJ, 350, h1771.
Hoffman, J. (1995, 02 May 1995). Judge Sets Aside Use of Cocaine as Part of Verdict in Zion Case. The New York Times.
Lerner, B. H. (2009). A Life-Changing Case for Doctors in Training. The New York Times. Retrieved 12 Mar 2023, from https://www.nytimes.com/2009/03/03/health/03zion.html
Nardil® (Phenelzine Sulfate Tablets, USP). In FDA (Ed.), FDA. accessdata.fda.gov.
Oura, P., & Sajantila, A. (2022). A recent two-fold increase in medical adverse event deaths among US inpatients. J Public Health Res, 11(4), 1-4.
Robins, N. (1995). The Girl Who Died Twice. Delacorte Press.
Serotonin. (2022). Cleveland Clinic. Retrieved 13 Mar 2023 from https://my.clevelandclinic.org/health/articles/22572-serotonin#:~:text=Serotonin%20is%20a%20chemical%20that,blood%20clotting%20and%20sexual%20desire.
Valkonen, V., Haatainen, K., Saano, S., & Tiihonen, M. (2023). Evaluation of Global trigger tool as a medication safety tool for adverse drug event detection—a cross‑sectional study in a tertiary hospital. Eur J Clin Pharma. https://doi.org/https://doi.org/10.1007/s00228-023-03469-5
Volpi-Abadie, J., Kaye, A. M., & Kaye, A. D. (2013). Serotonin Syndrome. Ochsner J, 13(4), 533-540.
----
You can support us by subscribing to ad-free content on Spotify for $0.99, or subscribing on Patreon at the $2 or $5 level and also get bonus content.
If you like the show, leave us a rating or a review, and/or share it with a friend! Every little thing helps to get the word out and help us find our people.
Follow us on social media!
Instagram: https://www.instagram.com/lethaldosepod/
TikTok: https://www.tiktok.com/@lethaldosepod
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Tumblr: https://www.tumblr.com/lethaldosepod