Lethal Dose

Episode 57: Fen-Phen


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In the 1990s, a new diet drug combination swept the US, promising an easy way to drop weight quickly. Soon thereafter, Redux joined the ranks, but the fatal side effects would soon come to light when thousands were injured with heart disease and neurotoxicity.

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Cohen, E., & McDermott, A. (1998). Who's fat? New definition adopted. CNN. Retrieved 29 Jul 2024, from http://www.cnn.com/HEALTH/9806/17/weight.guidelines/

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from https://www.medpagetoday.com/special-reports/slipperyslope/51044

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Fox, M. (2012). FDA approves weight loss drug, with a new name - Qsymia. NBC News. Retrieved 15 Aug 2024, from https://www.nbcnews.com/health/health-news/fda-approves-weight-loss-drug-new-name-qsymia-flna891310

Halsey, E. (1997). Woman says infant son is fen-phen victim. CNN. Retrieved 05 Aug 1997, from http://www.cnn.com/HEALTH/9710/10/fen.phen.babies/

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It was meant 2B. Pharm & Thera, 132(2), 146-157.

Johnson, D. B., & Quick, J. (2023). Topiramate and Phentermine. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK482165/

Kolata, G. (1997). How Fen-Phen, A Diet 'Miracle,' Rose and Fell. The New York Times. Retrieved 06 Aug 2024, from https://www.nytimes.com/1997/09/23/science/how-fen-phen-a-diet-miracle-rose-and-fell.html

Madrigal, A. (2008). New Weight-Loss Drug Like Fen-Phen, But Not As Heart Breaking. Wired. Retrieved 29 Jul 2024, from https://www.wired.com/2008/01/weight-loss-dru/

Mundy, A. (2001). Dispensing With the Truth. St. Martin's Press.

Phentermine. (2020). In LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. https://www.ncbi.nlm.nih.gov/books/NBK547916/

The Problem with Fen-Phen. (1998). Retrieved 24 Jul 2024, from https://www.sciencedaily.com/releases/1998/09/980902053528.htm

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Saul, S. (2005). Fen-Phen Case Lawyers Say They'll Reject Wyeth Offer. The New York Times. Retrieved 14 Aug 2024, from https://www.nytimes.com/2005/02/17/business/fenphen-case-lawyers-say-theyll-reject-wyeth-offer.html

Van Norman, G. A. (2023). Off-label use vs. Off-label marketing of drugs. JACC Basic Tansl Sci, 8(2), 224-233.

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