In this episode, I explore the manifestations and management of multiple sclerosis. I use powerful patient memoirs, such as that of Ann Romney, to illustrate the diversity of presentations and variants of this ubiquitous and devastating neuroinflammatory brain disease.

I also trace the history of multiple sclerosis with references to Lidwina, the patron saint of figure skaters. I also narrate the role played by French neurologist Jean -Martin Charcot in defining the disorder, starting with his observations of his own maid.

I also explore the risk factors, investigations, and increasing range of treatments now available for the disease.